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Biomedical subjects

V J Ferrans

Publications and source records attributed to V J Ferrans.

At least 415 records · Page 23Linked to original sources
PubMed1973

Intramitochondrial glycogen in hypertrophied infundibular muscle of patients with congenital heart diseases.

A small population of glycogen-containing mitochondria was found in operatively resected myocardium in 8 of 11 patients with various types of congenital heart diseases associated with right ventricular hypertrophy and muscular (infundibular) obstruction to right ventricular outflow. The presence of intramitochondrial glycogen correlated with the degree of peripheral arterial oxygen desaturation but not with the severity of hemodynamic alterations or with the ages of the patients. The occurrence of intramitochondrial glycogen in myocardium in other conditions is reviewed, and its possible pathogenesis is discussed.

Adolescent↗
PubMed1973

Significance of multiple intercalated discs in hypertrophied human myocardium.

Multiple intercalated discs were frequently observed in muscle cells from patients with cardiac hypertrophy of various causes. Evidence is presented that these structures are the intercellular junctions of lateral processes of muscle cells. The sizes and shapes of these processes showed marked variations, depending in part on the plane of sectioning. It is postulated that lateral processes develop in certain cells which have side-to-side intercellular junctions with adjacent cells, and that localized mechanical tensions induce their growth. These tensions are due to shearing forces exerted at side-to-side junctions when contraction occurs at different rates or magnitudes in adjacent cells. These forces lead to asymmetric and complementary growth of sarcomeres along the two sides of the lateral junctions, to reorientation of these junctions and to the eventual formation of lateral processes.

Adolescent↗
PubMed1973

Chylomicrons and the formation of foam cells in type I hyperlipoproteinemia. A morphologic study.

Light and electron microscopic study of aspirated bone marrow of a patient with type I hyperlipoproteinemia disclosed large, birefringent foam cells which develop from phagocytosis of chylomicrons by histiocytes. Chylomicrons are taken up, singly and in aggregates, by infoldings of the plasma membranes of histiocytes; these infoldings become phagocytic vacuoles within the cytoplasm. As chylomicrons are metabolized, the foam cells decrease in size, lose birefringence and develop autofluorescent, electron-dense deposits of ceroid.

Adult↗