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Biomedical subjects

V Ia Plotkin

Publications and source records attributed to V Ia Plotkin.

At least 19 recordsLinked to original sources
PubMed2000

[Changes in the interleukin-6 and interleukin-10 concentrations in the blood plasma of miners working in deep coal mines].

Blood plasma levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured in 45 miners working in a deep coal mine immediately after work shift using an immunoenzyme technique. The highest IL-6 level was recorded in those miners engaged in hard work under most adverse conditions of underground workings--it was found to exceed the control values. The same group of workers demonstrated the lowest level of IL-10 that differed from the control value. Miners aged between 41 to 50 years working in a coal mine, their underground service duration 16 to 20 years, displayed a decline in the level of IL-6. The coal mine miners with the 11- to 15-year service duration revealed an increase in the level of IL-10.

Adult↗
PubMed2000

[Blood plasma level of endothelin in miners of a deep coal mine].

In 60 miners working in a deep coal mine the blood plasma level of endoteline-1 (E-1) was measured by the immunoenzyme technique immediately after working shift. Those in the mining where the working conditions are especially harsh were found to have the highest level of E-1 exceeding the control values. In studying the age-related content of E-1 in blood plasma of coal miners the highest levels of E-1 were recordable in workers 20 to 30 years old, declining and differing in age groups 20-30 and 41-50 years old. The level of E-1 was at its greatest in those workers with minimum length of service in the underground conditions, declining with the service more than 10 years in duration.

Adult↗
PubMed1998

[The effect of acute and chronic overheating on morphological changes in the liver].

Disturbances were disclosed in the functioning of the lysosomal and vacuolar apparatus in an electronic and histochemical investigation of 75 Wistar albino rats and 10 control animals exposed to acute and chronic overheating, with the numbers and structure of lysosomes undergoing changes, lysosomal membranes disrupting, which event was accompanied by an outgo of lysosomal contents into the cellular cytoplasm and beyond. There was no longer Golgi apparatus as a single whole; cellular cytoplasm stored lipid drops of low electron density with membrane inclusion and products of reaction to acid phosphatase in their matrix. Disruption of lysosomes and identification of acid phosphatase in cellular cytoplasm and Disse's space was presumably a cause of damage to the Golgi apparatus.

Acute Disease↗
PubMed1995

[Effects of age and length of service on the state of the renin-angiotensin-aldosterone system and prostaglandin synthesis in coal miners].

Radioimmune assay determined serum renin activity, serum aldosterone level and its excretion with urine, amounts of thromboxane A2 (TxA2), prostacyclins PgI2 and PgF2a in urine of 76 apparently healthy miners before and after the working shift. Conventional techniques were used for estimation of blood and urine electrolytes and creatinine. In this connection activity of renin-angiotensin-aldosterone system (RAAS) in the miners before and after the work appeared to depend on the age and the length of service, to reach the maximum at the age of 31-40 and at 11-15 years of the service. Afterwards the activity lowered. The miners older than 41 had RAAS response decreased or absent after the work. Ratio TxA2 PgI2 remained unchanged in the miners over age of 41, whereas in the younger miners the ratio considerably decreased during the work.

Adult↗
PubMed1992

[The role of pharmacological tests in detecting disorders in the bronchial patency and bronchial reactivity of patients with chronic glomerulonephritis].

Data are reported of a study of the effect of atrovent, salbutamol and acetylcholine on bronchial patency and reactivity of the bronchi in 89 patients with glomerulonephritis (age: 17-49 years) with normal renal function and at the stage of chronic renal failure. The tests proved highly informative. Latent bronchospasm was found in 12.1% of patients with chronic glomerulonephritis. In 76.3% of patients at the stage of chronic renal failure hyperreactivity of the bronchi was found. The revealed changes require early diagnosis and treatment.

Acetylcholine↗
PubMed1991

[Effect of a single overheating on kidney ultrastructure].

Large human populations have to live and work under conditions of heat in the arid zones or in industry. It is shown in the experiment, that a single overheating of animals of various duration results in a considerable damage of glomeruli and tubules the clinical manifestation of which is the development of acute renal failure.

Acute Kidney Injury↗
PubMed1989

[Clinico-morphologic comparisons in mesangiocapillary glomerulonephritis].

Clinical, morphological and immunological examination was carried out in 146 patients with mesangiocapillary glomerulonephritis. The differences in the clinical manifestations of the disease were not significant. The lobular variant was more frequently distinguished by microhematuria, increased level of creatine and reduction of the blood serum complement. Morphological examination showed a significant increase of the mesangial matrix in the center of glomerular lobules.

Adolescent↗
PubMed1988

[One of the possible mechanisms of development and progression of chronic glomerulonephritis].

Proceeding from clinical examination of 430 patients with chronic glomerulonephritis (GN) and morphological, histochemical and biochemical studies on kidney biopsy specimens the author has proposed and substantiated a hypothesis, according to which prolonged raised protein reabsorption in cells of the proximal tubules (PT) of the kidney can cause breakage and distortion of the activity of transport systems responsible for the absorption and catabolism of macromolecules. These changes can result in PT cell breakage, escape of lysosomal enzymes into the lumen and basal membrane of PT cells and pericanalicular interstice with further development of cortical interstitial sclerosis. The combination of the above mentioned disturbances would lead to GN progression and development of renal insufficiency.

Atrophy↗
PubMed1986

[Nephrotic syndrome in primary glomerulonephritis].

The authors provide the clinico-morphological data obtained in 189 patients with primary glomerulonephritis (GN). The disease was manifested clinically by the nephrotic syndrome (NS). The NS was most commonly induced by membranous-proliferative GN (MPGN), membranous GN (MGN), diffuse mesangio-proliferative GN and focal segmental glomerulosclerosis (FSGS), accounting for 31, 25, 22.8 and 8.7% of cases, respectively. Hypertension together with edema was among the most common symptoms of the NS in adult patients. Functional disorders of the kidneys recorded in FSGS, MPGN and MGN patients were more significant as compared to those in other patients. The morphological findings alone, obtained with the aid of light, immunofluorescent and electron microscopy, play the key role in the diagnosis of different patterns of GN.

Adult↗