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Biomedical subjects

V I Novikov

Publications and source records attributed to V I Novikov.

32 records · Page 2Linked to original sources
PubMed1978

[Effect of phytohemagglutinin on T-lymphocytes isolated from human blood].

T--enriched lymphocyte fraction from normal donors was isolated from heparinized peripheral blood on Ficoll-Urotrast gradients. The mitogenic response of T-lymphocytes in culture was 3 times as high as that of unseparated mononuclear cells. The intensity of blast transformation to PHA did not correlate with the increase of T-lymphocytes in culture. These data suggest that cells of not T-origin may be the limiting factor during mitogenic response of T-lymphocytes to PHA.

Adult↗
PubMed1978

[Nature of the humoral factor from bone marrow stimulating antibody production].

An active factor doubling the antibody synthesis in the culture of immune lymph node cells was isolated from the supernatant of the cultures of bone marrow cells from intact donors. Gel chromatography was used for this purpose. The stimulant of antibody producers (SAP) was eluated at the site of cytochrome C exit; the factor is heat-stable and has the mol wt of 1300 daltons. SAP production needs RNA and protein synthesis, but does not require DNA synthesis. The radioactive label showed that SAP includes ribonucleotides and amino acids. It is suggested that SAP plays an important role in the regulation of antibody synthesis.

Animals↗
PubMedDate not supplied

[The effect of thymic peptides on the development of streptozotocin-induced diabetes mellitus].

Streptosotocin was administered to 21 test animals and 19 control ones. Preventively, the former were given T-activin, the latter--saline. 73% of the test animals were free of hyperglycemia, insulinopenia, activation of lipid peroxidation, morphologic evidence of beta-cell damage. In control animals diabetes mellitus arose in 84% manifesting with marked hyperglycemia, insulinopenia, LPO activation, morphological signs of beta-cell damage, lymphocytic infiltration of the islets. From the results obtained it can be concluded that T-activin has a prominent protective effect against diabetes mellitus (chi-square = 6.34, p < 0.05) which can be explained by its antioxidant and immunotropic activity.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Study of the glucocorticoid function of the adrenals in patients with diabetes mellitus using a minor dexamethasone test].

The purpose of the paper is to define the state of glucocorticoid function in 37 male and female patients with types I and II diabetes mellitus of various degree of compensation before and after dexamethasone blockade of the hypothalamohypophyseoadrenal system (0.5 mg 4 times for 2 days). The level of cortisol in the plasma was determined by a radioimmunoassay using Sorin kits. Statistical data processing was performed using the d-3-28 computer. In patients with types I and II diabetes mellitus at the stage of compensation the level of plasma cortisol did not differ from that of persons without diabetes mellitus; in decompensation of types I and II diabetes mellitus its considerable increase was noted. After the dexamethasone test the more pronounced was a degree of decompensation of diabetes mellitus, the higher was the level of cortisol, i.e. there was resistance to dexamethasone inhibiting action, especially in type I which could be accounted for by deeper metabolic derangements in this type of diabetes mellitus and an increase in the threshold of sensitivity of the hypothalamic centers to dexamethasone. Therefore the minor dexamethasone test could be used for determination of a degree of metabolic compensation of patients with diabetes mellitus.

Adrenal Cortex↗
PubMedDate not supplied

[Regeneration of sanitaro-hygienic water during long space flights by reverse osmosis].

Experiments on the purification of wash water by means of reverse osmosis membranes MGA-100 were performed. The membrane selectivity with respect to the major components (catamine AB, amine oxide and sodium chloride) was close to 100% whereas membrane permeability was not lower than 70% that of distilled water. The results of a field study in which 330 1 of repeatedly used wash water were reclaimed showed that reverse osmosis can be effectively employed for that purpose.

Membranes, Artificial↗