[Fluoroquinolones as antibacterial preparations and their use in the treatment of tuberculosis].
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Biomedical subjects
Publications and source records attributed to V I Kocherovets.
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The study was undertaken to improve transport and selective culture media and a testing scheme for dysbacteriosis. Great emphasis is laid on methods for isolating and identifying the nonclostridial anaerobes which are the major component of the normal human intestinal microflora. The following media were proposed: a) a sterility-checking-up medium, hemin, vitamin K1, cysteine, and twin 80 was for transportation of samples to a laboratory; b) anaerobic blood-containing agar with selective additives (kanamycin and bile) for isolation of bacteroids; c) a propionic acid-containing medium for isolation of bifidobacteria; d) a acetic acid-containing medium for isolation of lactobacteria. The use of the above culture media, microanaerostats, and three-component gas mixture substantially enhanced the efficiency of microbiological diagnosis for intestinal dysbacteriosis.
Pyo-inflammatory diseases continue to be one of the topical problems of modern medicine. Their etiological agents are opportunistic microorganisms among which non spore-forming anaerobes are prevalent in the normal microscopic flora. They cause a pathological process when the body's immunity is decreased. The authors consider the biological features of this group of bacteria, epidemiological and pathogenetic aspects, the problems of laboratory and clinical diagnosis of non clostridial anaerobic infection and outline immediate steps to be taken to solve the problems.
The paper summarizes the results from 15-year studies of non-clostridial anaerobic infection in obstetrics and gynecology. The authors show that strict non-spore-bearing anaerobic microbes are prevalent in the etiological pattern of pyoinflammatory diseases of the female genitals, present the basic pathogenetic features of the development and clinical signs of anaerobic infections. The present-day principles of diagnosis and treatment of these diseases are given. Prospects are shown for further studies of non-clostridial anaerobic infection in obstetric and gynecological care.
The scientific messages presented at the 3rd Asia Pacific Military Medical Conference are scrutinized. The encounter of about 200 military doctors from 14 countries of the appropriate region was heed in Jakarta in 1993, hosted by the Indonesian Army and sponsored by the United States Army Pacific Command. The Conference comprises 3 symposia on: military medicine and humanitarian assistance; malaria and parasitic diseases of military relevance; protecting the troops during tropical deployments. There were 53 reports in all, the leading ones belonged to American authors. Detailed discussions concluded every working day. In the whole the Conference reminded a regional seminar of military doctors in the shape of continuing medical education. The participants got qualification eredits in the field of tropical medicine.
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The results of treatment of 40 patients with acute purulent cholangitis developed against the background of choledocholithiasis are presented. Bacteroid of the kind B. fragilis (67.5% of cases), Fusobacterium, Lactobacillus sp. (30%) are the leading etiological factor of cholangitis. The indications for external and internal drainage of the bile ducts are substantiated. The ineffectiveness of internal drainage in this disease is demonstrated.
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The results of B-bile bacterial examinations of patients who had undergone operations on biliary tract for acute or chronic cholecystitis in the military medical institutions of the USSR and the USA were retrospectively compared. Distinctive and similar features were revealed. The leading role of bacteroids, anaerobic found bacteria and clostridia was ascertained during the studies of etiological structure of anaerobic biliary infection. As for nonclostridial anaerobic infection of biliary tract, the polymicrobiotic process of aerobic and anaerobic associations is more typical. The centralization of bacteriological examinations in specialized "anaerobic" laboratory may improve the efficiency of microbiological diagnostics of nonclostridial anaerobic infection.
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Purulent wounds in 88 victims of the Armenian earthquake with the syndrome of long-term squeezing were examined microbiologically and the experience with using antimicrobial drugs for their treatment was analyzed. In all the cases microbial associations were detected, coliform and nonfermenting gram-negative bacilli, enterococci, anaerobes and yeast-like fungi being isolated from 80, 20, 15 and 25 per cent of the patients respectively. 130 bacterial strains were studied in detail. 80 to 100 per cent of the bacterial isolates were resistant to the antibiotics routinely used in surgical practice, i.e. benzylpenicillin, tetracycline, levomycetin, kanamycin, cephalothin and cefazolin and highly sensitive to new antimicrobial drugs belonging to ureidopenicillins (mezlocillin), quinolones (ciprofloxacin) and cephalosporins of the 3rd generation (cefoperazone and ceftazidime). Retrospective estimation of the antibiotic therapy revealed its inadequacy in 55.7 per cent of the patients for the most part because of the isolates resistance. The 19 variants of the antibiotic use prescribed by the physicians mainly included penicillins, aminoglycosides and their combinations (in 67.2 per cent of the cases). The use of the highly efficient drugs of the groups of ureidopenicillins and quinolones was extremely rare which was likely due to lacking of information on the drugs.
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