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Biomedical subjects

V I Golovkin

Publications and source records attributed to V I Golovkin.

At least 19 recordsLinked to original sources
PubMed1996

[Modern diagnostic methods in multiple sclerosis].

161 patients with multiple sclerosis were observed according to C. M. Poser's scale. The diagnosis was definite in 73.9% of cases, probable--in 14.9% and doubtful in 11.2% of patients. The diagnostic significance of magnetic resonance tomography (MRT) was estimated as well as of visual evoked potentials (VEPs), mid-latency auditory evoked potentials (MAEPs), viscocontrastoperimetry and pallesthesiometry (vibratory sensation). MRT revealed alterations in 80.3% of 71 cases (97.5% at definite diagnosis). The results of investigation of evoked potentials differed from normal values: VEPs in 100%, MAEPs in 72.6% of 26 patients observed. Visocontrastoperimetry revealed disorders in 75,2% of 113 cases, pallesthesiometry in toes--in 100%, in fingers--in 68.9% of 116 patients observed.

Adult↗
PubMed1992

[Role of specific brain peptide factors in the pathogenesis and compensation of neurologic disorders and their use in the treatment of nervous system diseases].

New concepts of the molecular mechanisms implicated in the pathogenesis and compensation of central motor disorders are presented. It has been shown experimentally that specific peptide, postural asymmetry, and inactivation factors, play the leading part in these processes. The detection of these specific factors in the cerebrospinal fluid (CSF) of patients and convalescents allowed one to work out and test clinically a new method of treatment (CSF therapy) of patients with central motor disorders of varying genesis. The results of the clinical observations of two patients' groups (with cerebrovascular brain lesions and multiple sclerosis) are provided.

Adult↗
PubMed1992

[The interdependence between neurodynamic indices and the state of the hearing in blast trauma].

The authors have proved that in the blast trauma diagnosis of the organ of hearing in slight or middle-gravity cases it was necessary to applicate such important additional methods of researching as pure-tone and speech audiometry, and EEG. It gives the possibility to reveal the affections in primary and secondary cortical fields of temporal, occipital and frontal lobes, prognosticate the possible outcome of hearing pathology, elaborate optimal schemes of treatment, control the efficiency of therapy, and also make expert evidence conclusions. It was proved that the diminished hearing in patients who had suffered from blast injuries have a direct correlative dependency upon pathological deviations in EEG indexes. The severe neurodynamic disorders form an unfavourable background for recovery of hearing.

Adult↗
PubMed1991

[The neurological manifestations of blast trauma to the brain].

The article describes mechanisms of cerebral injuries and clinical symptomatology of light and medium trauma. It is stressed that a certain succession in medical and diagnostical measures must be observed, as well as physicians of several medical specialties must participate in the treatment of such cases. There is a description of morphological picture of cerebrum in this type of trauma. The article also shows pathogenetical and clinical differences between burst and mechanical brain injuries.

Acute Disease↗
PubMed1991

[Pathogenetic role of prolactinemia in multiple sclerosis].

RIA and rosette formation were employed to measure the content of prolactin and lymphocyte populations in the blood of 26 men and 36 women suffering from multiple sclerosis (MS). Hyperprolactinemia was discovered to be attended by a decline of the T lymphocyte count, whereas hypoprolactinemia was marked by the impairment of the ratio of active to total "rosettes". In addition, 16 MS women suffering from persistent galactorrhea-amenorrhea and 40 parturients and lactating women with MS were examined with a special purpose in view. A relationship was demonstrated between exacerbation and development of MS and the status of ++immuno-endocrine regulation.

Adult↗
PubMed1990

[Neuroendocrine aspects of the pathogenesis and treatment of disseminated sclerosis and lateral amyotrophic sclerosis].

Comparative study of neurologic, immunologic, and endocrinologic signs of disseminated sclerosis and lateral amyotrophic sclerosis was carried out by radioimmunoassay, monoclonal antibodies, and microcytotoxic Terasaki's test. The data have shown a tendency to hyperthyroid and hypocorticoid states in 60 percent of lateral amyotrophic sclerosis patients. Fluctuations in hormonal levels of disseminated sclerosis patients were quite the opposite in 37.5 percent of cases. Thyrotropic hormone content was rarely changed (in 20 and 18.75 percent of cases, respectively), this permitting a conclusion on the possibility of an extrahypophyseal (thymic) effect on the thyroid in these conditions and on the advisability of using thyrotropin- and corticotropin-releasing hormones (8-arginine-vasopressin) in combined therapy thereof.

Adult↗
PubMed1990

[Homeostatic effect of thymalin in multiple sclerosis].

The paper is concerned with interaction of the immune, endocrine and nervous systems in patients with multiple sclerosis. Dexamethasone and vasopressine tests were made. Lymphocyte sensitivity to hydrocortisone and thymalin, the main protein of myelin, was detected. It is advisable that arginine-vasopressine combined with thymalin be used for correction of homeostatic abnormalities and secondary disease prophylaxis.

Adrenal Cortex Function Tests↗
PubMed1987

[Multifactorial pathogenesis and immunoendocrine modulation of multiple sclerosis].

The results of immunogenetic screening of 300 patients with multiple sclerosis (MS) were subjected to factorial analysis. Nine significant factors indicative of secondary immunodeficiency were elucidated. The development and course of the disease were found to be affected by lipid metabolism disorders and endocrine deviations in the thymus-adrenal system. The authors postulate the principle of permanent immunoendocrine modulation in the treatment of MS. They also present data on hemosorption, lympho- and immunostimulation, as well as on correction of the interferon and cytochrome system.

Adrenal Insufficiency↗
PubMed1986

[Pathogenesis and treatment of migraine (neuroendocrinologic aspect)].

In 24 women with simple and ophthalamic migraine the authors employed neuropeptide 8-arginine-vasopressin under control of plasma levels of ACTH and cortisol and rheoencephalographic parameters. The authors observed a marked clinical effect, normalization of hypothalamoadrenal function and improvement in the cerebral hemodynamics.

Administration, Intranasal↗
PubMed1985

[Increase in the efficacy of corticosteroid therapy in multiple sclerosis].

Using modern tests (rosette formation, radial immunodiffusion, complement titration), 42 patients with the cerebrospinal form of multiple sclerosis were examined. The patients were divided into different categories on the basis of the ratios between lymphocyte populations in the peripheral blood. Corticosteroid therapy was indicated only when hypersensitization of the B-system of immunity was predominant. In other cases corticosteroids led to the aggravation of immune deficiency with regard to T-suppressors and clinical deterioration. The mechanisms of action of corticosteroids and the prospects of their employment in multiple sclerosis are discussed.

Adolescent↗