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Biomedical subjects

V Hlavatý

Publications and source records attributed to V Hlavatý.

At least 19 recordsLinked to original sources

Our experience in brachytherapy of certain non-cancerous diseases.

Brachytherapy of non-cancerous diseases has been used from the beginning of our century. The analgetic and antiinflammatory effects of gamma rays of the radionuclide Ra-226 has been used in the health resort in Jáchymov, located in Ore Mountains, Northern Bohemia since about 1911 in the therapy of patients hospitalized here with rheumatic diseases of joints, tendons and muscles, including the therapy of radical syndromes. The conditions for the therapy by this method are the age of above 42 years, normal blood count and certain other parameters commonly used in the non-cancer brachytherapy. The radiation dose depends on the degree of the involvement. The local single dose in our patients was of 1.8 to 3.5 Gy with an exposure time of 6 hours. In our work, we considered the degree of the damage to the skin on the irradiation site, after single dose, immediately after the application, as well as after the repeated irradiation in the course of several years. In persons followed, we also provided the examination of the blood count before and after irradiation. The results obtained demonstrated that the brachytherapy used in the health resort Jáchymov is safe and that it exerts no adverse effects on the patients submitted to it.

Brachytherapy

[Possible therapeutic applications of pulsed magnetic fields].

Magnetotherapy is a relatively new, nowadays however, relatively widespread method in several medical disciplines. The mechanism proper of the favourable action of the pulsed magnetic field on the living organism is not quite clear so far, clinical investigations revealed, however, a favourable anti-inflammatory, angioedematous and analgesic therapeutic effect. The authors sought an optimal frequency of the pulsed magnetic field with regard to the character of the disease. They focused attention above all on treatment of acute and chronic inflammatory conditions of the locomotor apparatus, ischaemia of the blood vessels of the lower extremities, dyspeptic syndrome, lactation mastitis and other diseases. One therapeutic cycle lasted 20 minutes, the mean number of cycles varied between 5.8 and 7.7. A regression of complaints was recorded as a rule after 2-3 sessions. The optimal frequency of the pulsed magnetic field seems to be a value between 10.0 and 25.0 Hz. It is useful in particular in severe conditions to repeat the therapeutic cycle after 2-3 months. The advantage of this therapeutic method is the minimal number of contraindications.

Humans

[Therapeutic results in lymphogranulomatosis and their relationship to immunological reactivity].

The efficacy of two treatment modalities of Hodgkin's disease stages I-IV (1) local irradiation of COPP chemotherapy with protracted low-dosage cyclophosphamide administration, or (2) all-round irradiation of lymphatic vessels or the same COPP treatment combined with shock doses of cyclophosphamide is evaluated. Duration of the first remission and survival time were followed in 45 patients in 1969-1978. During remission, some patients received a non-specific immunotherapy (BCG vaccination). The cumulative index of the first remission appeared to increase from 19 to 72% (radiation therapy) and from 14 to 68% (chemotherapy) within 3 years in the case of the second modality. The survival time of patients did not differ significantly in both study groups. Remission was longer in patients who had received BCG vaccination.

Antigen-Antibody Reactions

Effect of gamma ray low doses on the system of the nonspecific defense of the organism.

The author studied the response of the mechanical stage of the RES phagocytosis and the serum lysozyme level in white mice after fractionated exposures to 10 R and 100 R daily. It was observed the activation of these systems after low summed doses and, on the other hand, its significant depression after high summed doses. The causes of these changes are discussed.

Animals