An attempt to isolate critical periods of development in the rat.
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Biomedical subjects
Publications and source records attributed to V H DENENBERG.
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Mice were shocked with 0.1, 0.3, or 0.5 ma of current at 2 to 3, 8 to 9, or 15 to 16 days. Handled, nonshocked and nonhandled controls were also used. In adulthood each group was split into thirds and taught an avoidance response under shock of 0.3, 0.5, or 0.7 ma. The amount of shock given during infancy and adulthood, and the age at which shock occurred, were all found to have significant effects upon learning.
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Animals were handled during ages 1 to 10, 11 to 20, or 1 to 20 days, or were nonhandled controls. Animals handled for 20 days weighed the most in adulthood, while the controls weighed the least. Animals handled on days 1 to 10 survived food and water deprivation the longest of any group. Mice handled for 20 days died earlier than controls, while the reverse was true for the rat.
Significant differences in conditioning and response topography were obtained with two lines in C57BL/10 mice, suggesting the occurrence of a behavioral mutation. It is suggested that the two lines be classified as substrains. The two substrains would appear to be useful in experiments on the genetics of behavior.
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