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Biomedical subjects

V Grossmann

Publications and source records attributed to V Grossmann.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Effects of aflatoxin B1 on the sensitivity of the rat central nervous system to pentobarbital-Na racemate.

The immobility time of pentobarbital was prolonged in male rats treated with aflatoxin B1 (AFB1), 2 mg/kg, with maximum on the 3rd day after treatment. It cannot be fully explained by the pharmacokinetic mechanisms. In parallel ED50 of pentobarbital was decreased both in males and females. In males the lethal dose of pentobarbital was decreased by about 30%. The pentobarbital concentration in the brain was increased during the immobility time and at awakening after the ip administration of 40 mg/kg of the drug on the 3rd day after AFB1 treatment with doses of 1 mg/kg and 2 mg/kg po in males and females, respectively. The plasma concentration of pentobarbital was significantly increased in treated males only. The content of unchanged pentobarbital in urine within 24 h after its administration was not high (about 1% in males, 2% in females) and in the AFB1 treated animals it virtually did not change. The elevation of the brain level of barbiturate at the time of awakening in AFB1 treated animals may point to a decreased sensitivity to pentobarbital.

Aflatoxin B1↗
PubMedDate not supplied

Changes in the gastrointestinal tract, cardiovascular function and some drug metabolizing processes in rats and guinea-pigs intoxicated with aflatoxin B1.

The effects of aflatoxin B1 (AFB1) on the reactivity of the peripheral vessels, passage through the gastrointestinal system, production of hydrochloric acid and some liver functions were analyzed. The results shown the decreased glucuronidizing ability of the liver (58% of the initial value) accompanied by an increased amount of the unconjugated substrate while glycine conjugation was not changed in animals on the 3rd day after the treatment with AFB1. The uptake of 99mTc-SnO2 colloid was 1.14 times lower in the liver and 1.94 times higher in the spleen in AFB1 treated animals. A lowered activity of the glucuronizing system and a possibly indirectly lowered uptake of tin colloid in the liver indicate the toxic effect of AFB1 in hepatocytes. The other parameters studied were not changed or were changed only slightly.

Aflatoxin B1↗