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V Garrigues

Publications and source records attributed to V Garrigues.

54 records · Page 3Linked to original sources
PubMed1990

[Early complications of pneumatic dilatation in the treatment of primary motility disorders of the esophagus].

We analyze the incidence and evolution of the early complications of 96 consecutive patients with primary esophagus motor disorders, treated with pneumatic dilatation under endoscopic control (1.4 sessions per patient). In 4 (0.042/patient, 0.029/dilatation) patients the esophagus was perforated; the diagnosis was made in the first 24 hours; pneumomediastinum was a constant finding in the radiological exploration. In three cases the complication was suspected because of the apparition of sustained thoracic pain after the dilatation maneuver and in one case the presentation symptom was bleeding of cardial mucosa, larger than usual, at the end of the dilatation. The four patients evolved favorably with conservative treatment (avoidance of oral food intake, gastroesophageal aspiration, antibiotic therapy and parenteral nutrition).

Adolescent↗
PubMed1989

Prospective assessment of donor blood screening for antibody to hepatitis B core antigen as a means of preventing posttransfusion non-A, non-B, hepatitis.

The relationship between donor status for antibody to hepatitis B core antigen and the occurrence of non-A, non-B posttransfusion hepatitis in the recipient was prospectively studied in 112 patients undergoing open-heart surgery who were followed for 6.5 months after surgery. Non-A, non-B posttransfusion hepatitis occurred in five (7.93%) of 63 patients who had received at least one anti-HBc-positive blood unit compared to seven (14.28%) of 49 patients who received anti-HBc-negative blood only. Statistical analysis revealed that the incidence of non-A, non-B posttransfusion hepatitis was independent of the use of blood positive for anti-HBc. Based upon these results and the high prevalence (17.3%) of anti-HBc among our blood donor population, the exclusion of anti-HBc-positive blood does not seem appropriate to achieve a reduction in the incidence of non-A, non-B posttransfusion hepatitis.

Blood↗
PubMed1989

Effect of intravenous glucagon and glucagon-(1-21)-peptide on motor activity of sphincter of Oddi in humans.

Glucagon-(1-21)-peptide, the peptide containing the amino acid sequence (1-21) of glucagon, has the same spasmolytic effect as the complete molecule, without its metabolic action. The effect of glucagon and glucagon-(1-21)-peptide on sphincter of Oddi motor activity was evaluated in 20 patients undergoing ERCP and endoscopic biliary manometry. Glucagon produced a nonsignificant decrease in basal pressure, but significantly reduced both frequency and amplitude of phasic activity of the sphincter of Oddi. Glucagon-(1-21)-peptide showed no effect on basal pressure and amplitude of phasic activity, but provoked a significant reduction of frequency of phasic contraction.

Adult↗
PubMed1989

Endoscopic biliary manometry in patients with suspected sphincter of Oddi dysfunction and in patients with cystic dilatation of the bile ducts.

We studied the motility of the sphincter of Oddi in 12 patients with suspected sphincter of Oddi dysfunction, in four patients with cystic dilatation of the bile ducts (two Caroli's cases and two fusiform choledochal cyst cases), and in 33 patients with retained common duct stones. In these last 33 patients, the motor activity of the sphincter of Oddi was similar to that recorded in nine control subjects without pancreatic or biliary diseases. In the suspected Oddi dysfunction cases, both the basal sphincteric pressure and the frequency of the phasic contractions were significantly elevated (P less than 0.001). Patients with biliary cystic dilatation showed an increased basal pressure, but the frequency of the contractions was elevated in only those with choledochal cysts and the amplitude in only one of the two patients with Caroli's disease. Motor disorders of the sphincter of Oddi provide a basis for an alternative etiopathogenesis of cystic disease of the biliary system and a possible explanation for pain and dilatation of the bile duct in patients with suspected sphincter of Oddi dysfunction.

Adult↗
PubMed1988

Motor pattern of the sphincter of Oddi in patients with bilioenteric shunt: a manometric study.

An endoscopic biliary manometry was performed on 11 patients with a surgical bilioenteric shunt--choledochoduodenostomy--and no pressure gradient between common bile duct and duodenum. Basal pressure and frequency of the phasic waves of the sphincter of Oddi were significantly higher in these patients than in controls or in patients with retained common bile duct stones. These results suggest a functional adaptation of the sphincter of Oddi in an attempt to recover the normal pressure in the biliary tract.

Aged↗
PubMed1986

Return of esophageal peristalsis after Heller's myotomy for idiopathic achalasia.

A 23-year-old male was diagnosed as having idiopathic achalasia on the basis of clinical, radiologic, endoscopic, and manometric evaluation. He underwent a Heller's myotomy with 180 degrees posterior fundoplication as an antireflux procedure, and he did well subsequently. On reexamination one month later, return of peristaltic activity throughout the body of the esophagus was shown on manometric studies. Two years after the operation, peptic esophagitis was diagnosed by esophagoscopy, and the acid reflux test confirmed the existence of gastroesophageal reflux. To our knowledge, this represents the first reported case of return of esophageal peristalsis in idiopathic achalasia after surgical myotomy.

Adult↗
PubMed1986

Effects of atropine and pirenzepine on sphincter of Oddi motility. A manometric study.

We studied the Oddi sphincter motility by endoscopic manometry in 10 consecutive patients randomized in a double-blind fashion, after i.v. administration of two anticholinergic compounds (0.5 mg atropine sulfate and 10 mg pirenzepine). Pirenzepine significantly decreased the basal sphincteric pressure, as well as the amplitude and frequency of the phasic contractions. The only significant effect of atropine was the modification of the frequency of the phasic contractions, but only for a short period of time. Our results suggest that muscarinic innervation must be present for a normal sphincter of Oddi motility.

Adult↗
PubMed1986

Value of radionuclide oesophageal transit in studies of functional dysphagia.

Radionuclide oesophageal transit time was evaluated in 70 individuals, divided into three groups: normal individuals, patients with non-organic dysphagia and patients with primary oesophageal motility disorders treated with per-endoscopic forced pneumatic dilatation. In all of them the oesophageal transit time of a bolus of water with 18.5 MBq (500 microCi) of 99Tmc sulphur colloid was assessed, as was the percentage of residual activity of the bolus in the oesophagus. There was a significant difference in these parameters between the control group and the group with non-organic dysphagia, the diagnostic capacity of this test being 93% sensitivity, 100% specificity, 100% positive predictive value and 90% negative predictive value, which suggests its inclusion in diagnostic protocols of dysphagias. In patients with primary oesophageal motility disorders, a significant decrease in values of residual activity has been observed after treatment with per-endoscopic forced pneumatic dilatation.

Adult↗
PubMed1986

The effect of 180 degree anterior fundoplication on gastroesophageal reflux.

Sixty-seven patients with symptoms of gastroesophageal reflux not responsive to medical therapy were treated by 180 degree anterior fundoplication. The operative mortality was 1.5% (one patient). The follow-up period ranged from 6 to 132 months and averaged 3 1/2 yr. The overall clinical results were satisfactory in 94% of the cases; one patient had mild retroesternal heartburn after operation, and three patients had recurrence of symptoms with persistent reflux in two of them. Among the improved patients, one experienced a transient gas-bloat syndrome. In 41 patients manometric evaluation of the gastroesophageal high pressure zone showed a significant increase in both the pressure and the length below the respiratory inversion point (p less than 0.001) but not in the total length. The standard acid reflux test carried out on 47 patients after surgery was found to be negative in all of them. We conclude that in patients with severe gastroesophageal reflux, 180 degree anterior fundoplication achieved good clinical results confirmed by objective methods.

Adult↗
PubMed1982

Esophageal transection and paraesophagogastric devascularization performed as an emergency measure for uncontrolled variceal bleeding.

Thirty patients with portal hypertension underwent as an emergency measure esophageal transection for uncontrolled variceal bleeding. Murphy's anastomotic button and Prioton's clip were used for the transection in 16 patients and the Androsov autosuture stapler gun in the remaining 14 patients. According to the classification of Child, four patients were listed as class A; five, class B, and 21, class C. The survivors have been observed from one to six years. Successful control of the esophageal hemorrhage was achieved in all patients. Immediate operative deaths, within one month, occurred in 17 patients. Five patients had a recurrence of varices. Bleeding recurred in three patients. The over-all survival incidence has been 11 of 30 patients. All survivors are free of hepatic encephalopathy. Transabdominal esophageal mucosal transection with devascularization appears to be satisfactory, but according to our experience, an early recurrence of varices could be expected if the Androsov autosuture stapler gun had been used for the transection.

Adult↗