[Hospital interference as a iatrogenic factor in the neonatal period. The function of nursing in its elimination].
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Female↗
Biomedical subjects
V Gallardo
Publications and source records attributed to V Gallardo.
Acute effects of ethanol on liver blood circulation in the anesthetized dog.
A single, intraportal injection of ethanol (0.01 g/kg body weight) in the pentobarbital anesthetized dog elicited an immediate rise in the hepatic resistance to both portal and hepatic blood flows. Similar effects were produced by norepinephrine and these, as well as those of ethanol, were significantly reduced by yohimbine. Increased levels of noradrenaline were found in hepatic venous effluent during the vasoconstriction period induced by ethanol. We postulate that noradrenaline liberated from sympathetic nervous endings of the liver may be involved in vascular response to ethanol.
Animals↗
Measurement of dynamic surface tension to determine critical micellar concentration in lipophilic silicone surfactants.
Silicone surfactants are becoming increasingly important in the pharmaceutical and cosmetic industry, because of their versatility, low cost, and technological advantages. The present study was designed to measure the critical micellar concentration of three non-ionic silicone surfactants, one water-soluble and two lipid-soluble. We measured surface tension with a technique based on drop geometry. Solubility and dispersibility in water were tested in the two lipophilic surfactants with visible and UV light spectrophotometry. The data obtained with all techniques showed a characteristic behavior of lipophilic silicone surfactants, which did not entirely conform to the definition of critical micellar concentration.
Micelles↗
Serotonin-induced vasoconstriction is mediated by thromboxane release and action in the human fetal-placental circulation.
The possibility that prostanoids mediate the contractile response of serotonin on placental vessels was investigated. Rings of chorionic plate arteries and veins with and without endothelium were suspended in an organ bath for recording isometric mechanically activity. Serotonin caused dose-dependent contractions that were significantly attenuated by indomethacin (cyclo-oxygenase inhibitor, 10 microM) and SQ29,548 (thromboxane receptor antagonist, 1 microM). Pretreatment of placental venous and arterial rings with indomethacin decreased sensitivity (EC50) to serotonin of 2.3- and 1.9-fold, respectively. Pretreatment with SQ29,548 decreased sensitivity to serotonin of twofold in veins and 2.1-fold in arteries. In the endothelium-denuded placental arteries and veins, pretreatment with indomethacin and SQ29,548 reduced the serotonin-induced contraction in a similar way to that obtained in the endothelium-intact vessels. In isolated perfused cotyledon through the fetal circulation, serotonin caused a significant increase in perfusion pressure and stimulated thromboxane release 1.9-fold compared with basal values. Therefore, serotonin-induced vasoconstriction in the human fetoplacental circulation appears to be mediated in part by thromboxane release or action. This effect is not dependent on mediators released from the endothelium. The present study provides evidence for the participation of thromboxane A2 in the contractile response to serotonin in the human placental circulation. The ability of serotonin to release thromboxane A2 which is also a potent vasoconstrictor agent, may be important in increase fetoplacental resistance, one of the features of pre-eclampsia.
Endothelium, Vascular↗
[Stability of an oral liquid morphine formulation for pediatric use].
OBJECTIVE: The aim of this study the determination of the stability of an oral morphine hydrochloride solutions. METHOD: Determinations of a concentrated morphine solution of 4 mg/ml and the impact of two temperatures, 4 degrees C (refrigerator) and 25 degrees C (room) was analyzed via spectrophotometric measurements. RESULTS: Findings showed the high stability of the solutions at 4 degrees C, since no significant degradation was observed during the 30 days of the study, whereas at room temperature stability losses were hardly seen during the first 7 days, reaching 6.8% +/- 0.5% after 15 days. CONCLUSIONS: The tested morphine solution is stable at 4 degrees C during 30 days, but not at room temperature.
Child↗
Study of silicone vehicles for Aloe vera.
The effect of different surfactants on the synthesis of a silicone latex is studied. Distinct formulations were mixed and then tested with regard to stability as a function of time and temperature. The ones with the best characteristics for acting as a vehicle for the active cosmetic ingredient Aloe vera are indicated.
Aloe↗