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Biomedical subjects

V Gallai

Publications and source records attributed to V Gallai.

113 records · Page 7Linked to original sources
PubMedDate not supplied

[A case of mitochondrial myopathy with progressive chronic ophthalmoplegia (author's transl)].

Clinical, electromyographic, histochemical and ultrastructural features are described in a case of Chronic Progressive Ophthalmoplegia. The neurogenic-myogenic aspects of the diseases are discussed bearing in mind both electromyographic and histological findings ("red ragged fibres" etc.). Mitochondrial paracrystalline inclusions were found at the level of the ocular muscles as well as in the skeletal muscles. These inclusione suggest that Ocular Myopathy is a form of systemic myopathy secondary to mitochondrial abnormalities.

Electromyography↗
PubMedDate not supplied

Changes in auditory P3 event-related potentials in uremic patients undergoing haemodialysis.

A study on event-related P300 potential (ERPs) was performed in 20 patients suffering from chronic uraemia and undergoing haemodialysis in order to assessing the functioning of their cognitive processes. The patients were evaluated before and after a standard treatment of haemodialysis. The P300 potential was studied by means of the "oddball" paradigm and the acoustic modality. Moreover the patients' performance was assessed on the basis of the following psychological tests: the Mini Mental Test, the Number Connection Test and the Digit Span of the Wechsler Adult Intelligence Scale. A significant improvement in the P3 latency was demonstrated following the dialysis treatment. Even though a slight improvement in the N2-P3 deflexion amplitude was recorded after dialysis, it was not statistically significant. These data indicate a positive modification in the speed of the cortical function as a consequence of dialysis. These results suggest that the P3 latency obtained from auditory stimuli can help to assess the benefits obtained through extracorporeal dialysis, especially in the follow-up to the illness.

Acoustic Stimulation↗
PubMedDate not supplied

Desmopressin and imipramine in the management of nocturnal enuresis: a multicentre study.

The efficacy and safety of desmopressin (Minirin/DDAVP) treatment compared with imipramine were investigated in a multicentre, open, cross-over design in 57 patients, aged 6-15 years, affected by nocturnal enuresis to establish the best therapeutic approach to this condition. After a two-weeks observation and control period, patients were randomised to one of two groups: intranasal administration of desmopressin, 30 micrograms/day for three weeks, followed by imipramine, 0.9 mg/kg for a further three weeks, or imipramine 0.9 mg/kg for three weeks, followed by desmopressin, 30 micrograms/day for a further three weeks. Following treatment, all patients were observed for a further two weeks. Administration of either treatment protocol resulted in a statistically significant decline in the number of enuretic episodes per week compared to the control. The greater antidiuretic effect observed in the group receiving imipramine followed by desmopressin suggests the two compounds have different profiles. Also, when the treatment period was compared with the follow-up, the antidiuretic effect had a longer duration in the group initially given imipramine. No further improvement was seen when desmopressin was administered first, with a mild worsening of the effect sometimes occurring, suggesting a different carry-over effect between the two treatments. This suggests that desmopressin offers a better approach to the management of nocturnal enuresis.

Adolescent↗