Biomedical subjects
Publications and source records attributed to V G Fomina.
Nonspecific immunomodulators (complete Freund's adjuvant and bovine serum albumin) produced an antistress effect on mice during immobilization stress. Immunization with a serotonin-protein conjugate produced no antistress effect.
In this review the authors analyze neuroimmune aspects of the pathogenesis of such neuropsychic diseases as drug addiction, alcoholism, epilepsy, and pathologic pain. The role of pro-inflammatory cytokines in the development of pathological pain and epilepsy is discussed. The authors analyze their own data on the role of antibodies to neuromediators, such as catecholamines, serotonin, and glutamate, in the development of various forms of neuropathology, and outline the prospects of immunotherapy of the mentioned forms of neuroimmunopathology, including immunotherapy with conjugate on homological protein carrier.
We demonstrated a possibility of inducing antibody production against serotonin in high titers in rats by active immunization with serotonin conjugated with a homologous protein carrier (rat serum albumin) and with a foreign protein carrier (BSA).
Experiments on C57Bl/6 mice under conditions of free choice between alcohol and water for 10 months showed that intranasal administration with antiserotonin antibodies in doses of 30 and 15 microg/kg for 2 week decreased alcohol consumption over 1 month after treatment.
Immobilization stress for 14 h induced lymphopenia, hypoplasia of the thymus and spleen, and decrease in functional activity of T lymphocytes and macrophages in C57Bl/6 mice. Active induction of antibodies against serotonin during stress decreased functional activity of T lymphocytes and partially recovered phagocytic activity of peritoneal macrophages.
Phagocytic activity of peripheral blood neutrophils underwent phase changes in patients with Alzheimer's disease. Neutrophils retained the ability to engulf microbes, but their digestive activity decreased at the early stage of Alzheimer's disease. At the late stage we observed a decrease in the count of phagocytizing neutrophils, reduction of myeloperoxidase activity, and increase in the content of cationic proteins.
Plasma concentration of immune complexes and antibodies to serotonin and dopamine were higher in patients with Alzheimer's disease compared to mentally healthy volunteers of the same age. Plasma concentrations of antibodies to serotonin and dopamine decreased with the increase in the duration of this disease.
Experiments on C57Bl/6 mice maintained under conditions of free-choice between ethanol and water for 12 months showed that adoptive transfer of splenocytes extracorporeally stimulated with reaferon suppressed alcohol consumption within 1 month.
Experiments on C57Bl/6 mice kept under conditions of free choice between alcohol and water for 4 and 12 months showed that adoptive transfer of splenocytes extracorporeally stimulated with arginine vasopressin suppressed alcohol intake.
Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated with changes in the absolute neutrophil and monocyte counts.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.