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Biomedical subjects

V G Aristarkhov

Publications and source records attributed to V G Aristarkhov.

18 recordsLinked to original sources
PubMed2001

[Prevention of postoperative hypothyroidism in surgical treatment of diffuse toxic goiter].

Experience of treatment of more than 1000 patients with diffuse toxic goiter (DTG) is presented. Complex of measures performed before and after operation for reduction of hypothyroidism rate is developed. Histology examination during operation permits to determine volume of residual thyroid tissue. Local laserotherapy improves long-term results of surgical treatment. Rate of postoperative hypothyroidism in patients with DTG has decreased from 43.6 to 3.3%.

Adult↗
PubMed1999

[Surgical treatment for autoimmune thyroiditis].

The authors present the experience in the treatment of 1379 patients with autoimmune thyroiditis (AIT). 285 from them underwent surgery (20.6%). Conservative treatment with the use of laser therapy is a base in management of AIT (79.4%). Indications for surgical treatment and its scope were determined intraoperatively according to the results of an urgent biopsy of thyroid gland. They are: cancer of thyroid in combination with AIT, high degree of the risk of malignization, large size of the goitre with the symptoms of constringency of surrounding tissues, presence of pseudonodes and ineffectiveness of the conservative treatment and laser therapy. Follow-up data of the patients after surgical treatment for AIT showed that for several years their mode of life was quite favourable.

Adult↗
PubMed1997

[The dynamic observation of patients with diffuse toxic goiter in the postoperative period by means of echography].

The authors used vernier calipers for measurement of the thyroid remnant during operation with special reference to data of an emergency histological analysis which determined the state of toxicosis, lymphoid infiltration, the presence of the extrafollicular epithelium. In addition, the patient's age, duration of the disease and taking thyreostatics was considered. It determined an individual approach to solution of the question of size of the gland to be left. The fate of the remnant thyroid was followed-up with the help of echography. In the majority of patients with diffuse toxic goiter a 90% increase of the remnant as compared with the initial data was noted in a month after operation, six months later it was 126%, a year later 186%. Close functional correlation was found between the data of histological investigations, age of the patients, duration of the disease and taking thyreostatics.

Adolescent↗
PubMed1993

[Prognosis in the surgical treatment of diffuse toxic goiter].

Reduction of the incidence of postoperative hyperthyroidism (POH) is one of the urgent problems of DTG surgery. According to Soviet authors, it reaches 48%. The authors take into account a complex consisting of the patient's age, the degree of thyrotoxicosis, and the results of emergency (intraoperative) histological study. A program was elaborated with due consideration for adequate preoperative examination, preparation of the patients for the operation, a standardized method with reliable determination of the mass of the thyroid residue, morphometric examination of the removed part of the thyroid, study of the late-term results and their comparison with the preoperative clinical picture. Intraoperative determination of the percentage of active zones and the presence of intrafollicular epithelium and lymphoid infiltration made it possible for the authors to reduce POH incidence from 43.5% to 2.8%.

Adult↗
PubMed1991

[Diagnosis and treatment of acute pancreatitis].

From study of 549 patients with various forms of acute pancreatitis (AP) the authors conclude that membrane disorders occur in these patients, in which case membrane modulators, products of lipid peroxidation (PLO) among others, play an inducing role. In addition to the routine clinical data, of great significance for the diagnosis of AP are laboratory findings on lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, endogenous enzymes, transamidinase, concentrations of free kinins, blood coagulative system, study of free radical oxidation of lipids, beta-lipoprotein levels, etc. The authors recommend a wider use of fatty emulsions with heparin and intraarterial infusion of agents in the generally accepted complex of therapeutic measures. Operative treatment is usually indicated in approximately 20% of cases.

Acute Disease↗
PubMed1979

[Kidney functional dynamics in eliminating vasorenal hypertension by a kidney autograft].

In acute and chronic experiments on 45 dogs the authors obtained vasorenal hypertension, the elimination of which was fulfilled by means of autotransplantation of the kidney without transection of the ureter. The dynamical study of renal function was carried out through an analysis of arterial blood pressure, erythropoietic activity, blood serum, reticulocytic count, creatinine, residual nitrogen, diuresis, radioisotopic investigation, chromocystoscopy at open bladder, excretory urography, aortograhy, phlebography and morphometric studies of the renal glomeruli.

Animals↗
PubMedDate not supplied

[Functional changes and structural features of the testis in patients after acute parotid orchitis].

Structural changes and functional features of the testes were studied in 20 patients who had had parotid orchitis (PO) 6 months to 1.5 years before the study. The examination including ultrasonography of the testes, investigation of ejaculate, radioimmunoassay for serum testosterone, FSH, LH brought out a significant reduction of the mean volume and echogenicity of the affected testicles by 44.7 and 50%, respectively, in 15 patients; a 58.2% decrease in the number of spermatozoa in ml; a 71.2% rise in FSH level in 6 patients. Morphometry of biopsy specimen of the testicles on the affected side has shown that mean sectional area of the tubules has diminished by 40%, the spermatogenesis index--by 77.1% while the volume of the intertubular connective tissue increased by 47.7%. Thus, after acute PO, the patients develop atrophic changes in the testes and a decline in spermatogenic function up to secretory infertility.

Acute Disease↗
PubMedDate not supplied

[Surgical treatment of 286 patients with goiter in the Algerian People's Democratic Republic].

The paper is concerned with the results of the investigation of 286 patients with different types of thyroid pathology, operated upon by the authors over a 2-year period in the Algerian People's Democratic Republic. Of them 61.5% were patients with diffuse euthyroid goiter. The results obtained indicate that the mountainous areas of this country are goiter endemic.

Adolescent↗
PubMedDate not supplied

[Ways to decrease postoperative hypothyroidism in patients with diffuse toxic goiter].

The authors note that postoperative hypothyrosis is observed much more often than recurrences of thyrotoxicosis in patients with diffuse toxic goiter. The incidence of hypothyrosis is associated with the amount of the remnants of tissue, its functional abilities, regeneration, state of the hormonal and immune systems of the organism. The authors describe their method of determining the mass of the thyroid residue. The incidence of hypothyrosis was reduced from 43 up to 18%.

Follow-Up Studies↗
PubMedDate not supplied

[A rapid morphometric method for determining thyroid gland function].

The incidence of postoperative hypothyrosis after subtotal resection of the thyroid for diffuse toxic goiter is rather high, 40-50% according to many authors. A method is suggested permitting assessment of the share of "active zones" during surgery. A certain amount of thyroid tissue is left with due consideration for this share, this amount being sufficient to attain an euthyroid state in the postoperative period.

Goiter↗