Biomedical subjects
Publications and source records attributed to V Fritzsche.
The clinical behavior and the histogenesis of adenomatoid tumors of the uterus are discussed by means of an own case and of the relevant literature. For some time reports increase suggesting a mesothelial origin of this entity. These tumors are regarded as a variety of benign mesotheliomas. The own findings support this idea.
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Embryonal rhabdomyosarcomas consist of two histological variants; it can be distinguished between solid embryonal rhabdomyosarcomas and botryoid sarcomas. We investigated 13 solid and 7 botryoid rhabdomyosarcomas and used 46 biopsies of 20 patients between 6 weeks and 14 years old. There were 12 male and 8 female patients. The histologic examination yielded variations of cytologic pattern and tissue structure. Besides undifferentiated sarcoma cells which constituted the majority of tumor cells and a changing amount of rhabdomyoblastic cells (but only 40% of all tumors showed cells with cytoplasmic cross striation) in 6 solid and 6 botryoid tumors some other cellular features could be observed. There were tumor cells with characteristics of lipoblasts and histiocytes, and occasionally the potency to form vascular spaces was detected, too. The histochemical examination proved the presence of glycosaminoglycans and mucoproteins. The glycosaminoglycans seemed to contain only a few sulphated groups. In agreement with a preceding electron microscopic study of botryoid sarcomas in the nasopharynx (Katenkamp et al. 1979) we stated that many so-called embryonal rhabdomyosarcomas show the basic pattern of an undifferentiated embryonal sarcoma and have some diverging cellular differentiations. Therefore, it is an open question whether the term "embryonal rhabdomyosarcoma" should be defined more precisely than usually done in the routine histological work today.
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The correlations between macrophages and Schwann cells are studied on transsectional sciatic nerves from rats using the electron microscope. As early as 1 day after operation typical macrophages can be found within the endoneurial space of the proximal stump. On the other hand, 1 and 3 days as well as 4 weeks after operation Schwann cells may show cytoplasmic features comparable to that of macrophages. Our findings suggest that (1) macrophages are not able to transform into Schwann cells and (2) Schwann cells can act as phagocytosing cells exhibiting characteristics of macrophages. But in this functional state they can only be diagnosed as Schwann cells if a basement membrane and/or included axons with mesaxons are present.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.