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V Foltán

Publications and source records attributed to V Foltán.

10 recordsLinked to original sources
PubMed2005

[Pharmacoeconomic profile of antibiotics used in the treatment of lower respiratory tract infections in geriatric patients].

The paper aims to evaluate the pharmacoeconomic profile of antibiotics (ATB) used in the treatment of lower respiratory tract (LRT) infections and thus contribute to rationalization of therapeutic procedures. Of 2870 patients hospitalized at the Geriatric Clinic of the Medical Faculty of Comenius University from 1 January 1999 to 31 December 2001, 189 patients with acute infections of the LRT were included in the retrospective study. For pharmacoeconomic evaluation, cost effectiveness analysis was employed, the principal parameter of which, cost effectiveness coefficient, was the ratio of the price of ATB treatment in Slovak crowns (SK) and the criterion of effectiveness (E), the number of asymptomatic days in a month. The authors separately evaluated ATBs administered perorally (p.o.); intravenously (i.v.), and sequentially, and they also compared i.v. and the corresponding sequentially administered ATBs. Statistical comparison revealed significant differences in the prices and cost effectiveness coefficients of individual alternatives of ATB treatment. Employed ATBs did not significantly differ in the criteria of effectiveness. According to the cost effectiveness coefficient (SK/asymptomatic day), fluoroquinolones were less expensive (median price/E: pefloxacin: p.o. 19.3; i.v. 29.1; sequentially administered 26.0, and ciprofloxacin: p.o., 14.7, i.v., 54.1, sequentially administered, 31.7). Sequential administration of ATBs (ampicillin-sulbactam, cefuroxime, amoxicillin-klavulanate, ciprofloxacin) was significantly cheaper in comparison with i.v. administration. With therapeutic equivalence, the total pharmacoeconomic profile of ATB treatment depended on the price parameter. In the selection of ATB it is also necessary to consider the price of the drug.

Acute Disease↗
PubMed2004

Trends in consumption of opioid analgesics in Slovak Republic during 1998-2002.

OBJECTIVE: To describe the patterns of consumption in an opioid analgesic group in Slovakia between 1998 and 2002, to determine prescription habits, and to compare the results with those from selected countries. METHODS: A drug utilization study using WHO methodology [Anatomical-Therapeutic-Chemical classification/defined daily doses (ATC/DDD)] was made. The wholesale data from the State Institute of Drug Control in the Slovak Republic and drug safety reports from the National Centre for Supervision of Adverse Drug Reaction were collected. Utilization was calculated as the DDDs per 1000 inhabitants per day. RESULTS: Consumption of opioid analgesics (ATC class N02AA-N02AX) in Slovakia was still growing during the study with dominance of tramadol. In comparison with other countries in 2001, consumption of morphine (as a representative of analyzed ATC class) in Slovakia (0.17 DDD/1000 inhabitants per day) is still very low, in contrast with Denmark, Austria or Canada (1.80, 1.61 and 1.58 DDD/1000 inhabitants per day, respectively). The collected safety reports contained only a few reported adverse reactions to the opioid analgesics. CONCLUSION: Despite recent increases, the consumption of opioid analgesics in the Slovak republic remains low. We have tried to present an overall picture of prescription of opioid analgesics in Slovakia and to focus attention on this topic.

Adverse Drug Reaction Reporting Systems↗
PubMed2004

Factors influencing the spontaneous reporting of adverse drug reactions--the experience of the Slovak Republic.

The system of adverse drug reaction (ADR) monitoring in the Slovak Republic is greatly influenced by changes taking place in the current health care delivery system. Under-reporting and reporting biases due to selective ADR reporting provide very serious problems in pharmacovigilance. In the year 2001, the number of reported ADRs increased due to reports of angiotensin converting enzyme (ACE) inhibitor-induced cough; this coincided with limits being imposed on the use of angiotensin-II receptor antagonists. These factors provide an example of selective ADR reporting, deforming the quality of drug safety monitoring. They also indicate that administrative strategies can significantly affect spontaneous reporting activities.

Adverse Drug Reaction Reporting Systems↗
PubMed2002

[Pharmacoeconomics in the therapy of peptic ulcer].

The great prevalence and chronic nature of peptic ulcers traditionally represent a great economic load for the system of health care. The exponentially growing therapeutic and diagnostic possibilities of the treatment of peptic diseases are under a strong economic pressure from health-insurance companies. The use of an economic model for the management of peptic diseases aims to maximize health benefit from limited sources of the health services. It can be said already now that the detection of the Helicobacter pylori infection ranks among the most important discoveries of the 20th century. Elimination of the Helicobacter pylori infection can produce a dramatic reduction in relapses of peptic ulcers, which is reflected not only in the improved quality of life but also in a subsequent economic contribution. The present authors paid attention to the financial costs of the combined therapy for eradication of the Helicobacter pylori infection in the course of the years 1998-2001.

Cost-Benefit Analysis↗
PubMed2001

[Pharmacotherapy of osteoporosis in ambulatory practice and its pharmaceutical aspects].

Within the framework of studies of pharmacotherapy of the diseases of the muscular and skeletal system, the paper aimed to analyze the pharmacotherapy of osteoporosis. The significance of the problems in the field of research of epidemiology of osteoporosis requires the use of all available methods. With regard to the fact that the epidemiological situation in osteoporosis is also reflected in the consumption of drugs, the paper aimed to contribute to the solution of the problem by means of an analysis of the pharmacotherapy of osteoporosis. The results of the analysis have confirmed the relationship between the prevalence of the disease of osteoporosis and drug consumption. The paper demonstrated an increase in the total consumption of drugs prescribed for osteoporosis in 1998 and 1999 in comparison with 1997 as well as an increase in the consumption according to the age and sex. A statistically significant difference was recorded in the consumption of drugs prescribed for osteoporosis with regard to women. The analysis showed changes in the assortment of prescribed drugs as well as changes in the management of the therapy of osteoporosis.

Aged↗
PubMed1993

Poisoning in children.

Drug-induced poisoning of children represents a serious medical as well as a social problem linked both to the fields of prevention and therapy. This paper analyses the occurrence and the causative agents of poisoning cases of children under the age of 15, hospitalized in a children's hospital over a two-year period (1985-1986). 33 Poisoning cases represented 1.7% of all hospitalizations, and 49% thereof were induced by drugs.

Adolescent↗