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Biomedical subjects

V Felt

Publications and source records attributed to V Felt.

At least 127 records · Page 7Linked to original sources
PubMed1976

Serum levels of thyrotropin, prolactin, growth hormone, triiodothyronine and thyroxine after oral administration of thyrotropin releasing hormone in hypothyroid and hyperthyroid patients.

After peroral administration of TRH there were found elevated responses of TSH and HPr in hypothyroidism but not in hyperthyroidism. While the basal levels of TSH were elevated in hypothyroidism and depressed in hyperthyroidism, no such difference has been found in the case of basal levels of HPr. After TRH stimulation the levels of HGH decreased especially in hyperthyroidism; in patients with acromegaly serum HGH level increased after TRH. Serum T4 increased only in euthyroid persons after 2 and especially 24 hours, but not in hyperthyroidism or hypothyroidism. Mean values of serum T3 were elevated after TRH in all three groups, but the difference was significant only in euthyroid subjects. FT4I was increased in euthyroid person after TRH stimulation.

Acromegaly↗
PubMed1976

The effect of trimepranol on the binding of [3H] norepinephrine in myocardial subcellular fractions of the dog.

The effect of Trimepranol on the binding of 3H norepinephrine to myocardial particles from dogs (to fractions 1,000 g and 78,000 g resp.) has been studied and compared with the effect of propranolol, isoprenaline, phentolamine and ephedrine. Displacement of 3H norepinephrine by propranolol and isoprenaline was found in both fractions. Trimepranol, in low concentrations, inhibited the binding of 3H norepinephrine; in higher concentrations the binding of 3H norepinephrine was stimulated. Phentolamine and ephedrine were without effect in both fractions. The problem of specificity of adrenergic binding sites is discussed.

Adrenergic alpha-Antagonists↗
PubMed1975

Adrenergic binding sites and enzyme activities in the heart of hyperthyroid rats.

In present study interactions of some adrenergic drugs with the binding of 3H-norepinephrine (NE) and response of some enzymatic systems in the heart of rats with pharmacological hyperthyroidism have been investigated. Binding of NE to cardiac particles was inhibited by isoproterenol, propranolol and in lower concentrations by another beta-blocking drug trimepranol both in control and hyperthyroid hearts in the same degree. However, after addition of nonradioactive norepinephrine (10(-3) M) the degree of displacement was lower in hyperthyroid than in euthyroid group. Activity of adenylate cyclase was lower in hyperthyroid cardiac particles. This difference remained preserved after stimulation by norepinephrine or NaF. The activities of hormone-sensitive lipase and lipoprotein lipase were increased in preparation of hyperthyroid hearts. The phosphorylase "a" activity was also increased in hyperthyroid cardiac particles. There was no change in cardiac adrenergic binding sites properties in hyperthyroidism with the exception of less displacement of NE by nonlabelled hormone. The results indicate that the increased lipolytic and phosphorylase "a" activities in hyperthyroid hearts are not necessarily linked to elevated activity of adenylate cyclase.

Adenylyl Cyclases↗