[Patients with thyrotoxicosis. Changes in the systolic time interval, the Q-Kd interval, and the Achilles tendon reflex time].
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Biomedical subjects
Publications and source records attributed to V Felt.
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Cortisol binding by cytosol and 0.4 M KCl extract of the nuclear fraction of human leukocytes were studied by gel chromatography and ion exchange filtration on DEAE cellulose. The cytoplasmic cortisol binding protein has a molecular weight 95 000 and the soluble nuclear binding protein 50 000. The absence of the uptake of radioactive cortisol by isolated nuclei and the apparent requirement of the cytosol for glucocorticoid specific binding in nuclear receptor sites was observed. The association constant characterising the binding of cortisol to cytosol was KA = 3.5 . 10(9) l/mol.
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The authors summarize their experience with a simple test for the diagnosis of hyper--and hypothyroidism after oral administration of thyrotropin-releasing hormone (TRH). The practical advantage of this test is the absence of unpleasant side-effects described after the intravenous administration and elimination of stress of the patients and health workers associated with injection.
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