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Biomedical subjects

V Felt

Publications and source records attributed to V Felt.

At least 55 records · Page 3Linked to original sources
PubMed1984

HLA, Gm and endocrine diseases.

Differences in the frequency rates of seven signs determined by locus HLA-A and of 14 signs controlled by the HLA-B locus and also differences in the rates of appearance of four signs of the Gm system and that of the Inv(1) sign were searched for between patients suffering from diseases of the thyroid gland and healthy subjects. No statistically significant differences in the HLA system could be demonstrated when healthy subjects were compared to the diseased patients. In simple goiter patients there was a significant difference in the frequency rates of the Gm (1, 4, 5) phenotypes and a highly significant difference in the frequency rates of the Gm (1, 2, 4, 5) phenotypes. No direct association could be demonstrated between the above mentioned systems and the studied disease.

Chromosome Mapping↗
PubMed1984

Thyroid hormones and arterial distensibility in man.

The findings on the effect of thyroid hormones on the metabolism of the vascular wall are presented. In 231 subjects with hyper- and hypofunction of the thyroid gland the arterial pulse propagation time (APPT) and the APPT index (APPT I) were examined as indirect indicators of arterial extensibility. Age-dependent reduction of APPT and APPT I was found in euthyroid subjects as well as hyper- and hypothyroid patients. In younger subjects aged 20--39 years the APPT interval was shorter in thyrotoxicosis and longer in hypothyroidism. The authors discuss the role of changes in the rate of blood flow and changes of the arterial media in the interpretation of these findings. The index of the left ventricular ejection time (LVET I) does not change with age in any of the examined groups. Changes of the arterial wall in higher age groups in man manifested by shortening of APPT were not influenced by increased or reduced thyroid function.

Adolescent↗
PubMed1983

Effect of methylxanthines on binding of L-triiodothyronine (T3) to cytosolic and nuclear extract receptors of human leukocytes.

The effect of 15 mM methylxanthines (theophylline, coffeine) and 15 mM papaverine on T3 binding in the cytosol or nuclear extract receptors of human leukocytes was investigated by charcoal-dextran assay. In the cytosol, the presence of all three compounds increases the apparent association constants (KA) without affecting the total number of binding sites (N). Binding capacity was practically the same, only coffeine slightly decreases the number of binding sites. In the nuclear extract receptor protein, only theophylline increases its apparent affinity for T3.

Cell Nucleus↗
PubMed1983

Sexual differences in serum free amino acid levels in thyropathies.

Changes in serum free amino acid level with respect to sex and thyroid function are described. In euthyroid men, the amount of total, glucogenic, essential and nonessential amino acids is significantly higher than in euthyroid women. Patients with thyrotoxicosis exhibited increased levels of all main groups of free amino acids in blood serum. However, the sex-related differences in the main amino acids groups disappeared. The hypothyroidism was also accompanied by the disappearance of the sexual differences between the individual amino acids. The content of essential amino acids declined both in hypothyroid males and females. The participation of metabolic alterations of androgens and estrogens accompanying thyropathies in the genesis of sex-linked amino acid changes is discussed.

Adolescent↗
PubMed1982

Changes of essential amino acids in thyropathies.

Composition of free amino acids in serum of patients with thyrotoxicosis and hypothyroidism was studied by gas chromatography. In thyrotoxicosis the level of serum amino acids, especially the essential ones and several glucogenic amino acids, increased. The reverse was found to a lesser extent in hypothyroidism. Thyrotoxicosis exerted an increase and hypothyroidism a decrease in the value of the ratio of the sum of all essential amino acids versus the sum of all nonessential amino acids. The elevation of glucogenic amino acids in thyrotoxicosis is discussed with respect to hepatic function and amino acid mobilization and transport.

Adult↗
PubMed1982

Effect of theophylline on binding of triiodothyronine, thyroxine, thyroxamine, tetraiodothyroacetic acid and cortisol in the cytosol of human leukocytes.

Inhibition constants describing competitive potency of thyroactive analogues and cortisol against labelled triiodothyronine (T3) in cytosol in human leukocytes were determined in the presence and the absence of theophylline by means of charcoal-dextran assay. L-triiodothyronine, L-thyroxine,L-thyroxamine,L-tetraiodothyroacetic acid, D-thyroxine and cortisol competed with T3 in binding sites of cytosolic proteins without theophylline addition. While theophylline addition increased the competitive potency (decreased the values of inhibition constants) of all thyroactive analogues, no such equivocal effect has been found in the case of cortisol.

Binding Sites↗
PubMed1982

Changes of triiodothyronine and thyroxine in patients with thyrocardiac disease and their relationship to systolic time intervals.

The relationship between the ejection time from the left ventricle (LVET), the pre-ejection period (PEP) of the left ventricle, the Q-Kd interval, the course of the Achilles tendon reflex (ATR) and the thyroxine (T4) and triiodothyronine (T3) serum level in 184 patients with different grades of thyroid function was investigated. Some of these patients suffered from cardiac affection caused by thyrotoxicosis or ischemic heart disease. The significant inverse correlations between the T3 level and the duration of PEP, LVET, the Q-Kd interval and the ATR was revealed. An inverse relationship with T4 level was found only in the Q-Kd interval and ATR. In those instances, where there was a correlation with T4 and T3, higher values of correlation coefficients were observed in the correlation with T3. T4 concentration was higher in patients with cardiac affection. In thyrocardiacs was an increase in the quotient T4:T3, while in thyrotoxic patients without cardiac affection this quotient was rather decreased. The significance of disturbed T4 metabolism in development of cardiac affection in thyrotoxicosis is discussed with respect to ageing processes.

Achilles Tendon↗