Biomedical subjects
V Faber
Publications and source records attributed to V Faber.
[Ataxia telangiectasia].
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[Severe combined immunologic defect].
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Lymphocyte chimerism after bone marrow transplantation. Surface markers and in vitro function of donor and recipient lymphocyte subpopulations.
Specific HLA antibodies were used to eliminate donor and recipient cells, respectively, from lymphocyte suspensions prepared from the blood of a child who had been transplanted with bone marrow from an HLA-A- and HLA-B-incompatible, HLA-D-compatible donor. About 70% of the lymphocytes were of donor HLA type, the remaining of recipient type. The phytohemagglutinin-responsive lymphocytes were exclusively limited to the lymphocyte population carrying donor-type HLA antigens. Membrane immunofluorescence investigations of the donor and recipient populations showed a low percentage of IgM-positive lymphocytes in the donor population and an extremely high proportion of IgM-positive lymphocytes in the recipient population. About 90% of the donor lymphocytes were T cells, as judged by their capacity to form rosettes between sheep erythrocytes and T lymphocytes; no cells in the recipient cell population expressed this ability.
Rubella antibodies and acute viral hepatitis.
High antibody titres against rubella and measles viruses have recently been associated with certain chronic disorders such as chronic active hepatitis and occasionally with acute hepatitis. The present study was designed to evaluate the frequency of this association with acute hepatitis. Haemagglutination inhibition (HI) and complement fixation (CF) antibodies to rubella, measles and influenza A viruses were determined in 97 consecutive patients with acute viral hepatitis and in 97 control persons matched by sex and age. In patients, particularly in those over 30 years of age, a small but statistically significant increase in rubella HI titres was seen. In 3 hepatitis cases the rubella HI titres were very high (greater than or equal to 2 560). The antibody levels against measles and influenza A viruses did not differ from the controls. The present data indicate that a small proportion of acute hepatitis patients show a transient strong humoral immune response to rubella virus. The reason for this is not known.
Immunological studies in sarcoidosis: a comparison of disease activity and various immunological parameters.
We found it valuable to separate the heterogeneous types of sarcoidosis into more homogeneous groups on the basis of activity and duration of the disease. This view is supported in the present study by the finding of a marked depression of T-cell function in patients with chronic-active sarcoidosis. Patients with acute or chronic-inactive disease had only moderately depressed T-cell function as measured by tuberculin skin test and DNCB index. These results are in agreement with those of some previous investigations. The remainder of the abnormal findings, particularly low total number of circulation T lymphocytes, elevated serum IgG levels, and presence of autoantibodies, could not be correlated to disease activity, extent of the disease, or T-cell function. We have found no explanation for the presence of autoantibodies but suspect that they may be nonspecifically related to the disease process.
Immunological studies in sarcoidosis: a comparison of in vivo and in vitro Kveim tests.
No migration inhibition was observed in the 46 patients or the 12 controls when the Danish Kveim antigen was used in the LMAT. No migration inhibition was found in 23 of the same patients when the LMT was employed using the same antigens (Table 3).
Acute viral hepatitis: factors possibly predicting chronic liver disease.
A number of clinical, biochemical, immunological and morphological variables were recorded at first admission of 500 consecutive patients with biopsy verified acute viral hepatitis in the period February 1969-June 1972. In February 1973, 28 of these patients had a morphologically documented chronic liver disease: 4 cirrhosis of the liver, 15 chronic aggressive hepatitis, and 9 chronic persistent hepatitis. 74 patients were followed up until morphological normalization took place. The initially recorded variables in the two groups were compared, and the following factors were significantly higher in the group with subsequent development of chronic liver disease:--frequency of drug addicts, median of the highest gammaglobulin, ANA, SMA, partial destruction of the limiting membrane, incidence of piecemeal necrosis, and pronounced plasma cell infiltration in the portal tracts. These preliminary results suggest that factors in the initial phase of acute viral hepatitis can be helpful to some extent in predicting the course and prognosis of the disease.
Acute viral hepatitis: a comparative study of clinical, biochemical, morphological and immunological features in patients with and without Australia Antigen.
500 consecutive patients with acute viral hepatitis verified by biopsy were divided into groups of 202 patients with detectable Australia (Au) antigen and 298 patients without antigenaemia at the time of admission to hospital. Comparison was made of the initially recorded clinical, biochemical, histological and serological variables in the two groups. Judged by both histological and biochemical criteria, the acute disease was more severe in the 202 patients with Au antigen than in the 298 patients without Au antigen. Evidence is presented that this difference is possibly due more to qualitative aetiological differences between the two groups than to the duration of antigenaemia or the time of hospitalization. Thus, the demonstration of Au antigenaemia provides not only epidemiological but also relevant clinical information.
Antinuclear antibodies.
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Clinical, biochemical, immunological, and morphological features at time of diagnosis.
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Letter: Neutropenia with rheumatoid arthritis.
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Immunologic reconstitution in severe combined immunodeficiency with HL-A-incompatible bone marrow graft: donor selection by mixed lymphocyte culture.
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The occurrence and significance of abnormal bile duct epithelium in chronic aggressive hepatitis. A comparative morphological biochemical, immunological, and prognostic study.
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The occurrence and significance of abnormal bile duct epithelium in cirrhosis.
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