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Biomedical subjects

V F Portnoĭ

Publications and source records attributed to V F Portnoĭ.

At least 19 recordsLinked to original sources
PubMed1987

[Effect of cardioplegia on nitrogen and energy metabolism of the human heart].

The interrelation between the energy and nitrogenous metabolism of the myocardium during cardioplegia has been studied in patients with congenital valvular heart disease (tetralogy of Fallot--12 patients, ventricular septal defect--5 patients). Whole body hypothermia with repeated heart reperfusion with cold cardioplegic blood perfusate was used for the protection of the myocardium. However, ATP level of the myocardium of some patients decreased by 20% and more of the baseline. This loss was accompanied by a reduction in glutamate and aspartate levels and a rise in ammonium and alanine levels in the myocardium (by 17.7 +/- 3.8; 17.6 +/- 5.9; 61.4 +/- 12.5 and 92.4 +/- 26.3% of the baseline, respectively).

Adenosine Triphosphate↗
PubMed1986

[Electrophysiological study of the cardiotropic action of phenothiazine-derivative anti-arrhythmia preparations].

Cardiotropic action of antiarrhythmic agents etmozin and etacizin, phenothiazine derivatives, was studied electrophysiologically in 42 mongrel dogs (using isolated heart and intact body models). Etmozin produced no direct effect on sinus node function, whereas etacizin suppressed it in isolated hearts. Etmozin and etacizin significantly affected the atrial, atrioventricular-node and His-Purkinje conduction time, having no basic effect on the duration of respective refractory periods. Therefore, they can be referred to antiarrhythmic agents, group 1, subclass C. The magnitude and pattern of etmozin-and etacizin-induced electrophysiologic changes in the isolated heart and the integrated system are basically similar, an evidence of cardiotropic effects of these drugs. The model of an isolated dog heart perfused by a donor dog's blood can be used for the assessment of cardiotropic effects of drugs in preclinical trials of new antiarrhythmic agents.

Animals↗
PubMed1986

[Laser endoscopic destruction of the atrioventricular junction of the heart conduction system in an experiment].

Feasibility and degree of local AV junction destruction were studied prior to the induction of complete transversal block on the model of 18 isolated perfused dog hearts, using endoscopic laser device, employing cardiofibroscope and laser Ne: YAG. Morphological pattern in the destruction zone is presented. The technique and device can be used for transvenous AV junction destruction.

Animals↗
PubMed1982

[Changes in the electrical activity and coronary blood flow of a heterotopic heart allograft during a graft rejection crisis].

In 12 experiments on dogs heterotopic cardiac allotransplantation on the recipient's neck has been performed. During the transplant survival its electrical activity and the coronary blood flow (CBF) were recorded with an implanted sensor of electromagnetic flowmeter. The combination of relatively low CBF and the amplitude of R wave during the first hours after transplantation with a high heart rate is a poor prognostic sign. Oscillations of CBF run parallel to changes of ECG when the viability of the transplant is retained, during the rejection crisis these changes do not correlate. The significance of comprehensive assessment of the cardiac function with the use of ECG and CBF measurement and comparison of their absolute figures and dynamics is shown to be of importance for the early diagnosis of the rejection crisis.

Animals↗
PubMed1982

[Mechanical suture in bile duct surgery].

The authors describe results of using "one-agraffe" suturing devices and an original "many-agraffes" apparatus for suturing a wound of the common bile duct, papillosphincteroplasty and creation of bile-eliminating anastomoses in experiments in 47 dogs and clinical application in 104 patients. It was shown that these devices can considerably facilitate and accelerate the performing of operations, increase the hermetic properties of the suture and anastomoses, thus giving better remote results as compared with manual sutures with synthetic and catgut threads.

Absorption↗
PubMed1982

[Improved method of perfusion and functional loading of the isolated heart. Studies as a control and following cardioplegia].

The authors have elaborated and studied in 52 experiments an improved method of donor perfusion of an isolated dog heart. The technique of removing the heart without ischaemia and after cardioplegia as well as the technique of perfusion of the arrested and the contracting heart are described. The authors used their own method of the functional load testing of the left ventricle after cardioplegia. The function of the isolated dog heart without ischaemia was studied in control experiments. The advantages of the described method of perfusion and functional load of an isolated heart are: it is manageable, physiological and easily reproduced. The method can be used in experimental cardiology.

Animals↗
PubMed1981

[Maintenance of myocardial contractivity in dogs following cardioplegia using blood].

Dog hearts were perfused with a cardioplegic solution based on the blood (hemodilution, 20-25%, heparin, 60 mg/l, K, 20 + 25 mEq/l, pH 7.7, temperature 15 degrees C). The hearts were stored for 2 hours at 15 degrees C. Short-term cardioplegic perfusions were made every 20 minutes. It has been shown that the fragments of the left atrial auricle preserve high contractility which is close to the initial level after 1 and 2 hours of storage.

Animals↗
PubMed1980

[Effect of 5-fluorouracil on the enzymatic activity of the pancreas and blood serum of rats with acute pancreatitis].

The effect of 5-fluorouracil on the activity of pancreatic enzymes was studied in rats with acute pancreatitis. 5-Fluorouracil was injected intraperitoneally in a dose of 4.5 mg per 100 g body weight. Pancreatic transaminidase as well as serum alpha-amylase and trypsin levels decreased starting from 3--6h after the induction of acute pancreatitis. 5-Fluorouracil inhibited RNA and DNA synthesis and blocked the synthesis of pancreatic enzymes.

Acute Disease↗
PubMed1980

[Alloantigens of the formed elements of dog blood].

Absorption experiments showed that red blood cells of the dog contain some platelet antigens and only few leukocyte antigens. Canine platelets bear some leukocyte antigens. The main red blood cell antigens of dogs (DEA I. I. and 1.2) were detected in platelets and leukocytes, while other ones, weak red blood cell factors, were detected only in platelets. The lymphocytotoxic test showed, after separation of dog lymphocytes into T and B cells, that some antileukocyte sera including the samples directed against A and B series antigens of DLA system detect B lymphocyte-specific factors.

Animals↗
PubMed1980

[Heart-body biophysical model].

A biophysical model heart--body designed for experimental electrocardiographic investigations is described. The model consists of an isolated perfused dog heart immersed in a liquid volumetrical conductor filling the vessel in the form of a human torso with implanted electrodes for various ECG leads. The volumetrical conductor presents a hypotonic NaCl solution. In order to prevent heart damage by the solution, use is made of an artificial pericardium manufactured from current conductive rubber film.

Animals↗