Search PubMed⌕ Search

Biomedical subjects

V F Kondalenko

Publications and source records attributed to V F Kondalenko.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Distribution of collagen types I, III, IV and V in the walls of human arteries].

Using immunofluorescence the localization of I, II, IV, V type collagen in different layers of the artery wall was established. The adventitia was shown to contain only I and III type collagen. All collagen types studied were identified in the media. The structural organization and quantity of different types of collagen were found to depend on the artery caliber. The distribution of I, III, IV, V type collagen in the aortal intima is described. The localization of athrombogenic collagen of type IV and V in the area of the endothelial basal membrane is highlighted. The authors revealed the presence of I and III type collagen in the subendothelium and the age-related increase in interstitial collagen levels in the intima which is important for predicting thrombosis in deendothelization . Employing immunoelectron microscopy, previously undescribed forms of I, III, IV, V type collagen organization into microgranular structures were ascertained.

Arteries↗
PubMed1984

[Formation and accumulation of myelin bodies and other membrane structures in the arterial wall in man in atherosclerosis].

Unaltered areas and fibrolipid plaques of various human arteries were examined electronmicroscopically. Myelin bodies were found to be produced by smooth-muscle cells of the intima and media of unaltered parts of the arterial wall. The formation of myelin bodies by smooth-muscle cells significantly increases in the fibrolipid plaques. Myelin bodies are frequently located in the cytoplasm matrix of altered smooth-muscle cells, in the areas of myofilament lysis. They are also found within mytochondria and in the cystern lumina of the granular cytoplasmatic reticulum. The accumulation of membranous structures in the fibrolipid plaques results from myelin-body production by smooth-muscle cells and vacuoles and vesicules of a varying size.

Adolescent↗
PubMed1981

[Myofibroblasts in a myocardial infarct zone].

Electron microscopy and immunomorphological studies were made to explore the scar 2, 3, 4, 5, 7, 9, 11, 30, 45, 60 and 120 days after myocardial infarction in white rats. After 3-5 days there was a poor response to smooth muscle myosin in some of elongate cells of the postinfarction scar. The response was found to be remarkably enhanced after 11 days. Myofibroblasts with an ultrastructure characteristic of activated fibroblasts were found in the scar by using electron microscopy after 3-5 days of the experiment. They also exhibited some properties typical of the smooth cell ultrastructure, containing myofilament bundles with dense bodies along the cytoplasm periphery, as well as the fragments of the basal membrance. In the later periods of the experiment, myofibroblasts were more closely related to smooth muscle cells in ultrastructure. The origin and function of myofibroblasts in the postinfarction scar are discussed.

Animals↗
PubMed1981

[Electron microscopic study of signs of skeletal muscle fiber hyperplasia in athletes].

Biopsies of skeletal muscles obtained from volunteers, young (19--20 years of age) skilled sportsmen have been studied electron microscopically. Sarcolemmic invaginations, deeply intruding into sarcoplasm of the muscle fibres, have been found; they result in muscle microbud formations. Small, round, spindle-like or having irregular from muscle fibres have been found with longitudinally situated myofibrils in them, as well as narrow long young fibres, their contractile apparatus being incompletely formed, with great number of mitochondria, glycogen granules and polysomes. A suggestion is made that under a systematic physical training the human mature skeletal muscle undergoes hyperplasia of the muscle fibres. New muscle fibres might be formed from myosatellites, from segregating myosatellites and microbuds and also, possibly, by splitting the fibres already existing.

Adult↗
PubMed1979

[Skeletal muscle ultrastructure of untrained humans and animals after physical loading].

In non-trained mice subjected to a single and repeated swimming up to complete wearness, fibres in the skeletal muscles demonstrated certain ultrastructural alterations in their nuclei. Twenty-four and 48 h after a single swimming many muscular nuclei have only non-condensed chromatin. After repeated swimming large clumps of condensed chromatin appear in most of the muscular fibre nuclei. These nuclear changes are accompanied by segregation of separate fibrillar areas containing nuclei. Similar phenomena are also noticed in muscular fibres of non-trained people after a single physical loading. Ultrastructural changes in skeletal muscular fibres of volunteers, nonsportsmen are of individual character and depend on the degree of wearness resulting from the loading. In people subjected to the experiment and having severe fatigue (disability to work) significant shifts in submicroscopical structure of the fibrillar components were observed: in mitochondria, sarcoplasmic reticulum, T-system, contractile apparatus, etc. In this case, matrix becomes clear, lysis in mitochondrial crysts, dilatation of terminal cysterns of the sarcoplasmic reticulum and T-system tubes, destructive and regenerative processes in the contractile apparatus are observed. The data obtained demonstrate varied changes in ultrastructure of different components composing skeletal muscles of the non-trained organism subjected to physical loading.

Adaptation, Physiological↗
PubMed1975

[Morphological and ultrastructural characteristics of the epithelial cells of the parathyroid glands].

Histochemical and ultrastructural characteristics of the main, oxyphilic and C-cells of 50 parathyroid glands of man and 105 ones of animals (rats) is presented. Types of the structure of the structure of the parathyroid glands (compact, retiform, lobular) are identified and their morphological changes under conditions of impairment of the phosphorus-calcium metabolism are described.

Adult↗