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Biomedical subjects

V F Chuguĭ

Publications and source records attributed to V F Chuguĭ.

14 recordsLinked to original sources
PubMed2006

[Some neuroendocrinological changes in rats of cataleptic strain GC. Influences of ontogenesis and generation of breeding].

The content of biogenic amines: dopamine, noradrenaline and serotonine, in rats of cataleptic strain GC as compared with the control strain Wistar at the age of 1 and 5 months is decreased, the maximal decrease being found in the so-called "nervous" animals. The aldosterone content was decreased at 5 month age in the GC rats. The testosterone content at the age of 1 month in GC rats does not differ from that in Wistar rats, but at the age of 5 months it was decreased as compared to Wistar, the maximal decrease being found again in "nervous" GC rats. The data obtained point to peculiarities of ontogenetic regulation and to commonness of mechanisms of catalepsy and "nervousness" in GC rats.

Aging↗
PubMed2004

[Bipolar manifestation of cataleptic reactions in rats].

Selection of GC rats for the predisposition to cataleptic freezing has increased not only the frequency, intensity, and duration of freezing, but also the proportion of irritable or "nervous" rats with enhanced anxiety, defensive behavior with vocalization, jerky running, and jumpiness. An increased amplitude of the startle reflex is a correlate of this "nervousness." The results of the comparison of some behavioral characters in the nervous and freezing GC rats, as well as in F1 and F2 offspring from homogeneous crosses between nervous and freezing GC rats suggest that cataleptic freezing and nervousness are two poles of the same bipolar catatonic reaction. They have a common mechanism, with the alternative or preferential expression of one particular form of the reaction is determined by the external and internal environments or the set of modifier genes in the given individual.

Animals↗
PubMed2004

[Effect of experimental elevation and decrease of thyroxine level on catalepsy in rats].

Thyroid dysfunction is associated with mental disorders. The present study was aimed to reveal the effects of experimental decrease and increase of thyroxine level on expression of two types of extensive freezing: spontaneous and pinch-induced catalepsy, in Wistar rat males. Chronic administration of thyroxine synthesis inhibitor, propylthiouracil (5 mg/kg/day, 28 days), markedly decreased plasma hormone level and at the same time produced a significant increase in percentage of spontaneously cataleptic animals and immobility time, but had no effect on the expression of pinch-induced catalepsy. On the contrary, chronic thyroxin (0.1 mg/kg/day, 28 days) treatment produced no effect on spontaneous catalepsy expression, although it significantly increased percentage of cataleptic animals and immobility time of pinch-induced catalepsy. The results suggest that both the thyroid hormone deficit and excess provoke catalepsy in rats but enhance different forms of freezing reaction.

Animals↗
PubMed2004

[Catatonia or depression: the GC rat strain as an animal model of psychopathology].

The utility of "incomplete" genetic animal models of human diseases, in particular, psychoses, is discussed. The GC rat strain selected for predisposition to cataleptic reactions is described. It is shown that in many of their characteristics, GC rats are similar to schizophrenic and depressive patients. A possibility that akinetic catatonic states and depressions, hyperkinetic catatonic states and mania share common mechanisms is discussed. It is hypothesized that the GC strain may be an incomplete model of the common genetic and pathogenetic core of schizophrenic substuporous states and depression, which suggests the importance of returning to the issue of a unitary psychosis (Einheitpsychosis).

Animals↗
PubMed2002

[Correlation between cataleptic freezing and prestimulation inhibition of the startle reflex in rats].

In rats of GC strain bred for predisdposition to cataleptic freezing, a significant negative correlation between the duration of freezing and the level of prepulse inhibition (PPI) of the startle reflex, has been found. Besides, in a group of GC rats specific by their "nervousness" and jumpiness, there was also a negative correlation between the duration of freezing and the habituation to the startle reflex. None of this correlation have been found in Wistar rats. Since impairment of the PPI and habituation of the startle reflex is considered to be characteristic of schizophrenia, it is believed than cataleptic freezing in the GC rats may be used as a model of schizophrenic psychopathology.

Acoustic Stimulation↗
PubMed2001

[Effect of cross-fostering on catalepsy and the brain monoamine level in rat offspring prone to catalepsy and in the control strain].

Duration of cataleptic reactions in male rats of Wistar and GC strains depended both on the genotype and on the type of rearing: it was longer in the GC rats than in the Wistar ones. In the GC males reared by Wistar foster mothers this parameter was smaller than in the control GC but higher than in Wistar rats. The NA content was significantly lower in the GC cortex, hypothalamus and striatum, and the level of serotonin and 5-HIAA was lower in cortex of the GC as compared with Wistar rats. The cross-fostering affected monoamine content in some brain structures. On the whole, serotonin, DA and NA systems of the GC rats proved to be more susceptible to stress caused by cross-fostering than those of the Wistar rats. The cross-fostering diminished interstrain differences in the NA level in cortex, striatum, and hypothalamus.

Animals↗
PubMed2000

[Physiological manifestations of action of a gene regulating predisposition to a pendulum-like movements in rodents].

Physiological effects of the gene determining predisposition to a stereotypical hyperkinesis in the form of pedulum movements (PM) are manifested in some behavioral peculiarities (total motor activity, emotionality, intensity of the startle reflex, sensitivity of the 5-HT2 receptors, predisposition to catalepsy). High frequency of the PM occurring in Wistar rat stock suggests that the gene determining the PM expression is not a pathological one but controls some adaptive properties of the nervous system. Relationships between the PM expression and the degree of predisposition to catalepsy are biphasic and may be described by an inverted U-shaped curve.

Acoustic Stimulation↗
PubMed2000

[Effect of cross-fostering on various physiological and behavioral features in Wistar and genetically cataleptic rats].

In the GC rats reared by their natural mothers the plasma corticosterone concentration and open field locomotion were lower than in Wistar rats whereas the startle-reflex amplitude was higher. Cross-fostering did not affect the plasma corticosterone concentration or the startle-reflex amplitude. A negative correlation between these parameters was found. An open field test yielded lower results in Wistar rats reared by foster mothers belonging to the GC strain whereas the reverse cross-fostering did not affect the locomotion in GC rats. The data suggest that fostering affects the open field behaviour whereas cross-fostering effects depend on the genotype of fostered litter.

Acoustic Stimulation↗
PubMed1999

[Relationship between certain forms of catalepsy in rats. An attempt at genetic analysis].

Rats from strain GC selected for predisposition to "pseudocatalepsy" (a cataleptic response to an enforced vertical posture) are also characterized by an increased duration of pinch-induced catalepsy. Expression of catalepsy in F1 and segregation in F2 hybrids obtained from GC x Wistar crossing were analyzed. The results obtained indicate that a monogenic dominant inheritance with incomplete penetrance cannot be ruled out for both pseudocatalepsy and pinch-induced catalepsy.

Animals↗
PubMed1999

[Genetic relationships between catalepsy and pendulum movements in rats].

Predispositions to pendulum movements (PMs) and catalepsy was studied in rat strains selected for predisposition to catalepsy and for enhanced or suppressed PMs. Positive correlation between PMs and catalepsy at earlier stages of selection changed to negative at later stages. Based on these data, it was hypothesized that the genes that determine the predisposition to catalepsy affect the expression of the gene determining PMs in such a way that different PM alleles become dominant in the cases of moderate and strong effects of the catalepsy genes.

Animals↗
PubMed1987

[Possibility of major gene control over scale E of Cattel's test].

The segregation analysis is made of inheritance of the E factor of the Cattell's 16PF Questionnaire on the basis of a population sample consisting of 108 free-structured pedigrees. The possibility of major gene control of inheritance for this quantitative trait is confirmed.

Adolescent↗
PubMedDate not supplied

[Dual manifestation of catatonic reaction in rats].

Results of genetic, neurophysiological, neurochemical and pharmacological suggest that the cataleptic freezing and "nervousness" observed in the cataleptic rat strain GC have a common mechanism. There seems to be a physiological factor causing catalepsy, upon reaching a certain level of intensity, to be transformed into "nervousness", which is observed both at different period and/or moment of individual life and in the processes of breeding the strain for predisposition to catalepsy.

Animals↗