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Biomedical subjects

V Efimov

Publications and source records attributed to V Efimov.

6 recordsLinked to original sources
PubMed2001

Anomalous magnetic-field dependence of positive ion mobility in normal liquid (3)He.

The positive ion mobility in normal liquid (3)He has been measured as a function of external magnetic field up to 15 T at temperatures down to 3 mK. At 3.2 mK, the field dependence is found to exhibit a pressure-dependent broad peak followed by a large decrease at pressures above 20 bars. On the other hand, at 20 mK, a monotonic decrease with increasing the magnetic field has been observed in the same pressure region. Possible origins for these anomalous behaviors are discussed.

Journal Article↗
PubMed1998

[A methodological study in a space flight simulation context].

To study the effects of isolation and confinement on small groups during long space flights, it is habitual to use closed hyperbaric ground chambers. For the first time, the European Space Agency made use of a nautral environment taking advantage of an Antarctic winter-over at the French Dumont d'Urville Station. The main objective of that study ("International Antarctic Psychological Programme"), was to compare different Russian tests used for training cosmonauts to a W. European approach validated during previous winter studies and European ground chamber simulations. Russian techniques appeared to be oriented to a narrow range of phenomena and unsuited to discern the adjustment to stress conditions.

Adaptation, Psychological↗
PubMedDate not supplied

PNA-related oligonucleotide mimics and their evaluation for nucleic acid hybridization studies and analysis.

DNA mimics containing phosphonate analogues of PNAs (pPNAs), particularly PNA-pPNA hybrids as well as hetero-oligomers consisted of pPNA units and PNA-like molecules on the base of trans-4-hydroxy-L-proline (HypNA) have been synthesized. The evaluation of their effectiveness in assays based on the hybridization technique in the comparison with natural oligonucleotides and classical PNAs has shown a high potential of these mimics as sensor molecules for nucleic acid based diagnostics and as molecular probes for mRNA isolation.

Biosensing Techniques↗
PubMedDate not supplied

Messenger RNA isolation using novel PNA analogues.

Homo-Thy hetero-oligomer probes composed of trans-4-hydroxy-L-proline based PNA-like (HypNA) monomers and phosphono PNA (pPNA) monomers demonstrated strong binding to complementary poly A+ RNA strands. We used a mixture of chimeric oligomers containing both "linear" and "clamping" PNA-analogues to develop an mRNA isolation procedure and demonstrate the improved recovery of RNA molecules with secondary structure at the 3'end as well as RNAs with short poly A tails.

DNA↗