Biomedical subjects

V E Hofmann

Publications and source records attributed to V E Hofmann.

3 recordsLinked to original sources

PubMed2001

[Eleven years of experience with permanently implanted port-systems in 329 cancer patients].

Intravenous port-systems are predominantly used for long-term chemotherapy in oncology. 164 of our patients were implanted with a Port-a-Cath and 165 patients with a Chemosite system. Indications, the duration of implantation, the duration of use, the access and complications were analysed. This retrospective study analyses 329 tumor patients, who have been treated at the Cancer Center Klinik im Park from September 1987 until February 1998. The preferred access of implantation were: v. subclavia (47%) and v. cephalica (35%). The average duration of implantation was 279 days for the Port-a-Cath system and 443 days for the Chemosite system. The most frequent complication immediately following surgery was a pneumothorax in 4% of the patients. The frequency of late complications was: thromboses 2%, infections 4%. This study analyses our experiences with fully implantable permanent intravenous catheter-systems in 329 tumor patients. These catheters can be used for very long periods with a low rate of complications.

Adult↗

PubMed2001

ECT and automatic internal cardioverter-defibrillator.

Electroconvulsive therapy (ECT) is a relatively safe and effective treatment even in depressed patients with preexisting cardiovascular diseases. However, little is known about its use in patients with automatic internal cardioverter-defibrillator (AICD). This case report describes a successful administration of ECT in a treatment-refractory depressed patient with an AICD, where the AICD device was deactivated during each ECT treatments and reactivated immediately upon completion of each treatment. The presence of an AICD should not be a contraindication to receiving ECT.

Aged↗

PubMed1979

Fibrinogen: agreement of experimental and calculated hydrodynamic data with electron-microscopic models.

There is no general agreement on the size and shape of the fibrinogen molecule. We have studied the diffusion of the fibrinogen in solution by means of dynamic light scattering, nanosecond fluorescence depolarization and analytical ultracentrifugation. The results obtained under physiological concentration, pH an ionic strength are DT = 2.0 X 10(7) cm2sec-1, DR perpendicular = 40'000 sec 1. Nanosecond fluorescence depolarization yielded DR parallel = 1.6 x 10(6) sec-1. Tentatively this value is interpreted as DR parallel, namely rotational diffusion about the major axis of the molecule. The sedimentation coefficient is 8.1 S. The hydrodynamic parameters derived from our measurements were compared with those calculated on the basis of the models proposed by Hall and Slayter, Hudry-Clergeon and Marguerie et al., Bachmann and Lederer, and Köppel. The agreement is poor even if the degree of hydration is varied within wide limits. However, satisfactory agreement can be achieved by assuming a flexible molecule of about 900 A length corresponding to two end-to-end bound trinodular structures of the Hall and Slayter type, with a nodule diameter of about 45 A. Experimental evidence indicates that the discrepancies between the different models might be due to different techniques of sample preparation leading to different conformations of the molecule.

Fibrinogen↗