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Biomedical subjects

V E Boston

Publications and source records attributed to V E Boston.

58 records · Page 4Linked to original sources

Anorectal Manometry as a diagnostic method in the neonatal period.

Presented are the results of manometric investigation of 63 neonates. The method was correct in 92% of all cases at first investigation, and if delay was justifiable on clinical grounds, this figure rose to 98%. Most problems in diagnosis using this method were related to abnormal smooth muscle contractility, which is regarded as being the most important single factor to determine. In patients in whom contractility was abnormal, sepsis, hypoxia, and hypothermia were associated with the generally poor clinical condition. The return of normal contractility paralleled the improvement in the patient's general clinical condition. Neither the maturity nor the size of the patient was felt to be a factor influencing the success or failure of manometry as a diagnostic method.

Anal Canal↗

Diagnosis of Hirschsprung's disease by quantitative biochemical assay of acetylcholinesterase in rectal tissue.

Acetylcholinesterase activity was measured in rectal-biopsy specimens obtained from nineteen children. Seven children in whom the diagnosis of Hirschsprung's disease was established were found to have a significantly higher enzyme activity than the twelve in whom this diagnosis was excluded. The estimation may prove to be of value in the diagnosis of Hirschsprung's disease.

Acetylcholinesterase↗

Bilateral pelvi-ureteric avulsion following closed trauma.

A 9-year-old girl suffered severe multiple injuries in a road traffic accident. Following a period of anuria an intravenous pyelogram was performed indicating bilateral pelvi-ureteric rupture. Continuity was eventually achieved on both sides following two attempts at ureteral anastomosis. One year after the accident the child is well and the kidneys and ureters are functionally normal. Early diagnosis and treatment is essential in order to achieve a good functional result. This is aided by an awareness of the condition and is confirmed by intravenous and retrograde pyelography. The anastomosis is performed over a polythene splint, supported by a defunctioning nephrostomy for several weeks. The aetiology remains obscure, although there have been many suggestions regarding the mechanics of pelvi-ureteric avulsion.

Accidents, Traffic↗