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Biomedical subjects

V Duverger

Publications and source records attributed to V Duverger.

15 recordsLinked to original sources
PubMed2006

[Acute superior mesenteric vein thrombosis. A retrospective study of 9 patients].

AIM OF THE STUDY: To determine diagnostic modalities and both immediate and long-term treatment of superior mesenteric venous thrombosis. PATIENTS AND METHODS: Retrospective study from 1997 to 2004 in two institutions concerning patients with superior mesenteric vein thrombosis. RESULTS: Nine patients (all males, mean age=55 years), were included. Abdominal pain (100%), vomiting (44%), and bowel activity disorders (44%) were the most common symptoms. A personal or familial thrombosis history was present in 67% of patients. A genetic predisposing factor of thrombosis was present in 78% of patients. The diagnosis was established with CT-scan in 8 cases with a mean delay of 8 days. Treatment was exclusively medical in 33% of patients and included surgery in 67%. All operated patients underwent resection for bowel infarction and only one had immediate anastomosis. All enterostomies were subsequently closed. No patient died. CONCLUSION: Diagnosis of superior mesenteric vein thrombosis is frequently delayed and relies on CT-scan with intravenous contrast. Prognosis is globally favourable but depends on early application of anticoagulation therapy. In case of surgery, bowel-sparing resection is indicated and enterostomies are often needed. Genetic disorders predisposing to thrombosis are very frequent, that may indicate prolonged even definitive anticoagulation therapy.

Abdominal Pain↗
PubMed2004

The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).

In this report we show that mithramycin considerably increases the direct cytotoxic effect of tumour necrosis factor (TNF) on tumour cells in vitro. Sensitisation to TNF-induced apoptosis was prevented by the broad caspase inhibitor zVAD-fmk, whereas overexpression of Bcl-2 had no effect. Mithramycin also potentiated cell death induced by Fas agonistic antibodies. In contrast, mithramycin reduced the percentage of cells undergoing apoptosis due to factor withdrawal. TNF-induced activation of NF-kappaB (NF-kappaB)-dependent gene expression was not modulated by mithramycin treatment. Concomitantly with the increased sensitivity, the protein level of the short-spliced cFLIP variant was downregulated. These results indicate that mithramycin enhances TNF-induced cell death in an NF-kappaB-independent manner, and suggest that the Fas-associated death domain protein plays a crucial role in the TNF-sensitising effect of mithramycin.

Adaptor Proteins, Signal Transducing↗
PubMed2001

[Blunt force rupture of the thoracic aorta and diaphragm: an unusual association].

The aim of this study was to report two cases of rupture of the right hemidiaphragm with intra-thoracic liver hernia, associated with a traumatic aortic disruption. These two lesions followed traffic accidents, and were both treated separately. Both patients had a long-term favourable progression. Association of these two lesions is particularly rare: fewer than 50 cases have been previously described in an extensive review of the literature. CT-scan seems to be particularly efficient in diagnosis, even if less efficient than other more specific explorations. The order of surgical management is guided by the physical examination, and especially by abdominal emergency.

Accidents, Traffic↗
PubMed2001

[Black esophagus associated with hypothermia].

The authors report a clinical case concerning a necrotizing esophagitis following severe hypothermic shock. They recall the usual aetiology of the "black esophagus", emphasize the importance of ischemia and the multispeciality management of this very unfrequent disease.

Esophagitis↗
PubMed2000

Regulation of MVM NS1 by protein kinase C: impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects.

Minute virus of mice NS1, an 83-kDa mainly nuclear phosphoprotein, is the only viral nonstructural protein required in all cell types and it is involved in multiple processes necessary for virus propagation. The diversity of functions assigned to NS1, together with the variation of its complex phosphorylation pattern during infection, suggested that the various activities of NS1 could be regulated by distinct phosphorylation events. So far, it has been demonstrated that NS1 replicative functions, in particular, DNA-unwinding activities, are regulated by protein kinase C (PKC), as exemplified by the modulation of NS1 helicase activity by PKClambda phosphorylation. In order to determine further impact of phosphorylation on NS1 functions, including the induction of cytopathic effects, a mutational approach was pursued in order to produce NS1 variants harboring amino acid substitutions at candidate PKC target residues. Besides the determination of two additional in vivo phosphorylation sites in NS1, this mutagenesis allowed the segregation of distinct NS1 functions from one another, generating NS1 variants with a distinct activity profile. Thus, we obtained NS1 mutants that were fully proficient for trans activation of the viral P38 promoter, while being impaired in their replicative functions. Moreover, the alterations of specific PKC phosphorylation sites gave rise to NS1 polypeptides that exerted reduced cytotoxicity, leading to sustained gene expression, while keeping functions necessary for progeny virus production, i.e., viral DNA replication and activation of the capsid gene promoter. These data suggested that in the course of a viral infection, NS1 may undergo a shift from productive to cytotoxic functions as a result of a phosphorylation-dependent regulation.

Animals↗
PubMed2000

[Surgical abstention in closed injuries of the spleen].

Splenic conservation avoids the overwhelming postsplenectomy infection. The high percentage of patients treated by noninvasive procedures would be due to the simple clinical course of splenic trauma and precision of diagnosis, using CT scan. Only clinical evaluation could provide further information on the indications for surgical treatment, as there is no available score regarding the value of CT scan for choosing the therapeutical option. Non-operative management of splenic ruptures should be considered in selected patients in whom hemodynamics is stable and closely monitored.

Adult↗
PubMed2000

[Spontaneous internal carotid artery dissection].

Spontaneous carotid artery dissection is one of the main causes of stroke in young adults. We report two cases occurring after non-traumatic hyperextension of the head. Most of these events result from minor head trauma. Some family history cases would suggest the possibility of an underlying artery wall disorder. The favorable natural history of carotid dissection emphasizes the need for a noninvasive approach for diagnosis. Delayed diagnosis may lead to poor prognosis. Ultrasonography and magnetic resonance angiography are adequate for diagnosis.

Adult↗
PubMed1997

[Subadventitial cyst of the popliteal artery. Non-invasive explorations. Anatomo-pathologic data].

Subadventitial cyst of the popliteal artery is a well known entity. We report a new case and the diagnostic and therapeutic advantages of noninvasive explorations. Transcutaneous duplex-scan provided diagnosis and showed cystic formations in contact with a segmentary occlusion of the popliteal artery. Magnetic resonance imaging (MRI) evidenced communication between the cysts and the articular capsule of the knee joint. Surgical exeresis confirmed the communication with the synovial fluid. This observation demonstrated: i) the contribution of duplex-scan for the diagnosis of adventitial cysts and arterial consequences; ii) the contribution of MRI in identifying communication with the synovial fluid; iii) the presence of arterial wall lesions (necrosis of the media) would favor no conservative treatment.

Humans↗
PubMedDate not supplied

[Cecal volvulus].

Explore the source record for details and available documents.

Abdomen, Acute↗
PubMedDate not supplied

[Uterine rupture. Apropos of a series of 52 cases from the brush].

Study of a new series of 52 cases of hysterorrhexis observed at Oddiene, county town in the North-West of Ivory Coast, underlines the pejorative impact of isolation and of the insufficiency of monitoring of the pregnancies in remote areas. The paper details causes and consequences of such an obstetrical catastrophic event, and reports some conclusions of the surgical treatment in which suturing is the most frequent act.

Adult↗
PubMedDate not supplied

[Paraganglioma of the organ of Zuckerkandl].

From the study of one case of non secreting paraganglioma of the organ of Zuckerkandl, the authors have surveyed the existing literature gathering 95 cases from 1902 to 1992. It is an exceptional tumor of the paraganglioma and it often a secreting one. When it is not it looks like a malignant retroperitoneal tumor. The surgical resection is often performed without the operating diagnosis. Asserting the malignancy of these tumors only depends on the presents of metastasis appearing lately. There fore a long continued control of the patients who have been operated upon is a must all the more as 30% of the paraganglioma of Zuckerkandl prove to be malignants.

Adult↗
PubMedDate not supplied

[Influence of the Strasbourg School of Health (1794) on the creation of the Imperial School of the Military Health Service].

The two-hundredth anniversary of the creation of the School of Health in Strasbourg was celebrated on December 3rd, 1994. Early in its history, the School also trained officers in the military health service. The close relationship between civilians and the military at the School led to the creation of the Imperial School of the Military Health Service which opened its doors in Strasbourg in 1856. Teaching was unfortunately halted by the war in 1870 and the school did not reopen until it was transfered to Lyon in 1888 where the former organization of the Imperial School of Strasbourg was maintained. "Si la faculté de Strasbourg a emprunté plus d'un de ses professeurs à la médecine militaire, combien celle-ci, en même temps, ne lui a-t-elle pas fourni de disciples?"

France↗