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Biomedical subjects

V Dordević

Publications and source records attributed to V Dordević.

At least 19 recordsLinked to original sources
PubMed1995

Effects of growth factors on the enzymes of purine metabolism in culture of regenerating rat liver cells.

Hepatocytes are affected by many cytokines and growth factors during liver regeneration. In regenerating rat liver cells cultures, liver cell growth factor (LCGF), hepatic stimulator substance (HSS), interleukin-1 beta (IL-1 beta), as well as their combination, were tested for their ability to activate the enzymes involved in purine metabolism. The enzymes tested were 5' nucleotidase, AMP deaminase, adenosine deaminase and xanthine oxidase. The cytokines alone or in combination, activated 5' nucleotidase and adenosine deaminase. Activity of AMP deaminase was stimulated by IL-1 beta associated with LCGF, HSS and IL-1 beta. Xanthine oxidase was stimulated by IL-1 beta but not with HSS and LCGF. Associated with IL-1 beta these two substances decreased its activity. A novel approach to the understanding of the mechanisms involved in the regulation of purine metabolism during liver regeneration, is proposed.

5'-Nucleotidase↗
PubMed1994

[Recurrence around tracheostomies: analysis of risk factors].

302 patients with planocellular larynx carcinoma treated by total laryngectomy during the period from 1975 to 1986 were analyzed. In the examined group of patients significant risk factors in tracheostoma relapse appearance were the next: glottis-subglottis tumor localization and regionally spread tumor. Planned postoperative radiotherapy can significantly reduce the risk of tracheostoma local relapses' appearance.

Carcinoma, Squamous Cell↗
PubMed1994

[Treatment of severe craniocerebral injuries].

During 1992. 19357 patients were examined at the Department for Neurosurgery of the Emergency Centre, Clinical Center of Serbia, out of which 15879 had head injury. In addition to those necessitating hospitalisation, there was also a large number of patients with mild head injury that were not admitted for hospital management and were sent home following initial first aid. The average incidence of these patients was 45 patients per day during 1992. During 1992. a total of 1,978 patients were hospitalised, out of which 1,520 (84%) were injured. A total of 633 patients (25%) were hospitalised due to injuries sustained in traffic accidents. All patients were examined and evaluated according to the standard protocol including GCS as well.

Adolescent↗
PubMed1990

Intra- and extracranial circulatory changes in cigarette smokers assessed by ultrasound: transcranial Doppler (TCD) and duplex scanning investigation.

The group of 98 "healthy smokers" was analyzed in order to evaluate potential influence of cigarette smoking on intracranial blood flow disturbances and extracranial carotid intimal changes, performing transcranial Doppler (TCD) and Duplex scanning of the carotid arteries. Almost 70% of smokers analyzed in our study had some intracranial circulatory changes, predominantly in the vertebral arteries (35%). Half of smokers analyzed had some pathological intimal changes in the carotid arteries. The most frequent finding was wall thickening (23%) and then calcified (13%) and soft plaques (10%). Dose response relationship between smoking and atherosclerosis is also introduced. More than 30 cigarettes smoked per day can significantly influence plaque development and already 20 cigarettes smoked per day can cause significant intracranial blood flow disturbances. The majority of our investigated smokers were in high risk category for development of cerebrovascular disease and 5% were in a very high risk category. Cessation of cigarette smoking will eliminate it as a risk factor. A low dose-response relation and the development of tolerance produced by exposure to nicotine were also introduced.

Adult↗
PubMedDate not supplied

[A quiet clinical course in an otogenic brain abscess].

INTRODUCTION: The occurrence of otogenic intracranial complications has been significantly diminished by introduction of antibiotic therapy, improved diagnostic methods and surgical treatment of chronic otitis. Meningitis is still the most frequent otogenic intracranial complication, otogenic brain abscesses are following, while other complications occur rarely (1,2,3). Otogenic meningitis and brain abscesses are often associated, which makes the on time diagnosis of each complication harder. Mortality from otogenic brain abscesses is still relatively high, despite diagnostic and therapeutic achievements (4.5). CASE DESCRIPTION: The aim of this study is to present a patient with brain abscess, which arose quietly, as a consequence of chronic suppurative otitis and to point at possibilities of diagnostics and treatment of this complication. The diagnosis of brain abscess by clinical methods of examination is not always reliable. It is often accompanied by most severe form of meningitis, so that neurological examination, in most cases, reveals only signs of meningitis. In our patient, the abscess has been detected by computerized tomography, in its late stage, when it already had completely formed a capsule and had shown clinically manifesting focal signs. This case is interesting because of quiet and unperceived evolution of brain abscess. In the active phase of chronic suppurative otitis, the patient was receiving antibiotic therapy, which has most likely hidden the early symptoms of evolution of intracranial infections. The appearance of signs of focal intracranial infection (photophobia) required applying computerized tomography revealing brain abscess, which was clearly bounded, with a developed capsule, pointing at its late stage (about two months). These findings lead to a conclusion that an otologist should always keep in mind and check whether there is an intracranial infection in cases of active phase chronic otitis.

Adult↗