Peripheral arterial diseases: treatment with ketanserin as i.v. infusion. An open study in 20 patients.
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Biomedical subjects
Publications and source records attributed to V Di Giovanni.
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A case of isolated left-sided inferior vena cava, without situs inversus, in a patient with abdominal aortic aneurysm is reported. On the basis of a review of literature, the authors recall the incidence and the embryology of this anomaly, and analyze its surgical implications, with particular reference to abdominal aortic surgery.
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1 Effects of some antiepileptic drugs on the repetitive activity of the node of Ranvier have been tested on frog myelinated nerve fibres. 2 Nerve fibres were stimulated by supraliminal direct current pulses of long duration. Motor fibres responded with a single action potential; sensory fibres responded with repetitive firing at a frequency of about 300/s. Chlordiazepoxide hydrochloride (0.1 mM), phenobarbitone sodium (0.25 mM) or diphenylhydantoin sodium (0.5 mM) suppressed the repetitive activity. 3 Sensory and motor nerve fibres stimulated by a 10 kHz alternating current of strength twice the threshold responded with repetitive firing at a frequency of 400-500/s. Superfusion of the node with chlordiazepoxide hydrochloride (0.2 mM), phenobarbitone sodium (0.5 mM) or diphenylhydantoin sodium (1.7 mM) reduced the frequency of firing by 50% either in sensory or in motor fibres activated by a.c. stimulation; at the same concentrations, the drugs altered amplitude of the action potential and threshold for electric excitability by less than 10%. 4 Unlike local anaesthetics, chlordiazepoxide, phenobarbitone and diphenylhydantoin are more selective in inhibiting repetitive firing than in reducing the amplitude of the action potential or increasing the threshold for electric excitability. 5 Trimethadione (up to 5 mM) was ineffective on repetitive firing elicited either with direct or with alternating current.
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A patient developed an arteriovenous aneurysm between the gastroduodenal and middle colon arteries and the main mesentericoportal vein, following gastroduodenal resection. This case is described, and patients with arteriovenous fistulae in the portal region reported in the published literature (179 cases) are reviewed. Etiological, pathological, and clinical aspects in relation to surgical treatment and according to the type and location of the lesion, are also discussed. Emphasis is placed on a study of physiopathological problems, and the effects provoked by these fistulae on portal vein hemodynamics, arterial hemodynamic function, and on the general circulation are analyzed in greater detail.
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