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Biomedical subjects

V Della Mea

Publications and source records attributed to V Della Mea.

26 records · Page 2Linked to original sources
PubMed1996

Computer-assisted morphometric analysis of the heart.

OBJECTIVE: To assess the applicability of the image analyzer for morphometric study of cardiomyopathies. STUDY DESIGN: A computer-assisted methodology for the morphometric study of ischemic cardiomyopathy, dilated cardiomyopathy and right ventricular dysplasia. RESULTS: In each heart, 200 nuclear lengths and myocyte diameters, 160 fields for nuclear density, 420 fields for interstitial fibrosis and 350 fields for replacement fibrosis were evaluated. In ischemic cardiomyopathy, the multiple foci of replacement fibrosis of the myocardium, in addition to interstitial fibrosis, appear to be the major cause of ventricular remodelling. In dilated cardiomyopathy the major pathologic processes are myocyte cell death and segmental, replacement and interstitial fibrosis. In right ventricular dysplasia the heart develops congestive failure due to a conspicuous increase in the volume of the right ventricle without an appreciable loss of the number of myocytes. CONCLUSION: The traditional morphometric methods based on test grids for the study of pathologic hearts can be enhanced using an image analyzer. In this way one can study a large area of the myocardium and collect a very large number of data. This may be the method of choice for analyses of pathologic human hearts.

Cardiomyopathies↗
PubMed1995

Structure analysis of breast lesions using neighborhood graphs.

The College of American Pathologists divides proliferative lesions of the breast into three categories, but the diagnostic criteria for classification are not easy to apply. Therefore, many morphologic, immunohistochemical and morphometric features were studied in order to clarify this subdivision; however, the reported results are not very satisfactory. We also attempted to identify and differentiate the architectural features useful for the diagnosis of proliferative breast lesions. The morphologic characteristics of proliferative lesions of the breast were considered amenable to a graph theoretical approach. From a set of images of mammary ducts acquired from a hematoxylin-eosin-stained section, a hierarchy of graphs was built. The main graphs representing the structure are: (1) neighborhood graph, (2) planar graph, derived from (1) and (3) a dual graph. A simplified prototype of a system for structure analysis of the lesions was implemented and tested. Forty duct images classified by two expert pathologists were acquired and subjected to the system. The data obtained were analyzed, and some significant graph features validating our approach to the structure representation of the lesions were discovered. This approach can also be applied to other, similar classification problems and may help in understanding the biologic significance of proliferative lesions of the breast.

Breast Neoplasms↗
PubMed1995

[The Internet for medical research].

In every scientific field, research is based on communication and information share: scientific journals and meetings meet this natural need. Recently, there was a growing development of a new tool enabling knowledge share in fast and efficient manner: the Internet computer network. Now, Internet connects the majority of world scientific organizations and the number of network users is more and more increasing. In particular, the information hypermedia connection called World Wide Web, is very useful for scientific purposes. In addition, as biomedical informations are also available on Internet, it becomes an important and irreplaceable resource on physician's desk.

Computer Communication Networks↗
PubMedDate not supplied

Internet agents for telemedicine services.

Telemedicine can be defined as telematic support of collaboration between distant medical professionals, co-operating on shared resources of various kinds. Attention should be paid to telematics and informatics concepts, especially those oriented towards collaboration. In particular, the recent agent paradigm seems suitable for the analysis, design and development of telemedicine services because of its commitment to intercommunication and sharing of resources. The present paper is an introduction to the agent paradigm from its theoretical basis to the technological issues, and describes an agent-based approach to telemedicine, specifically applied to telepathology applications. The system is based on an agent-based model and template (JAMES) using Java, which has been used to implement a prototype multipurpose telepathology application based on a federated agency architecture.

Internet↗
PubMedDate not supplied

Telepathology applications of the Internet multimedia electronic mail.

Telepathology is based on the sharing of medical images coming from the microscope, and comprises different applications: intra-operative telediagnosis, second opinion teleconsultation, reference case archives, remote data and image processing, quality assessment. Since the Internet is available worldwide, it can be of interest to define which of these tasks can be performed by means of some telepathology method based on it. This paper focuses particularly on the use of Internet multimedia electronic mail for exchanging multimedia cases. To test the validity of the proposed approach for transmission of multimedia cases, the first step is to evaluate its diagnostic accuracy. Trials involving the transmission of 299 cases have been carried out between two departments of Pathology in Italy (at the University of Udine and at the City Hospital of Trento, respectively) in order to evaluate the diagnostic accuracy as well as the time needed for acquisition and transmission. First results show that good diagnostic agreement can be reached, but the time needed for transmission, generally low, is not sufficiently affordable to be adopted in those cases where time is important. In particular, telepathology through multimedia e-mail can be adopted for second opinion consultation, remote image processing, quality assessment and continuing education possibly by means of software that integrates acquisition and delivery of cases with HIS functionalities.

Evaluation Studies as Topic↗