Biomedical subjects

V De Martelaer

Publications and source records attributed to V De Martelaer.

2 recordsLinked to original sources

PubMed1996

Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes.

Despite strong evidence for genetic involvement in the etiology of affective disorders (from twin adoption and family studies), linkage and association methodologies are still exploring the nature of genetic factors in these diseases. Interesting testable hypotheses have been described, including candidate genes involved in catecholamine neurotransmission. We studied 69 bipolar patients and 69 matched controls (for age, sex, and geographical origin) for association and linkage disequilibrium with DNA markers at the following genes: the tyrosine hydroxylase gene, dopamine transporter gene, and dopamine D2 and D3 receptor genes. Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample.

Adult↗

PubMed1979

Psoriasis and cell cycle: a computer simulation.

Computer simulation using a two-phase model of the cell cycle has demonstrated that a transitory shift in the normal balance between the rate of cell flow to the differentiated and that to the proliferative compartment is sufficient to cause a permanent increase in the germinative population, thus resembling the alteration found in psoriasis. This shows the coherence of the hypothesis that cell kinetic parameters need not necessarily be expected to differ in psoriasis as compared with normal epidermis. This theoretical demonstration raises the possibility that the psoriagenic agent need not necessarily be present as long as the symptoms of psoriasis persist. From a therepeutic point of view this has implications that are sifficiently evident to warrant communication of this work.

Cell Cycle↗