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Biomedical subjects

V D Vuzevski

Publications and source records attributed to V D Vuzevski.

At least 19 recordsLinked to original sources
PubMed1992

Directional atherectomy for treatment of restenosis within coronary stents: clinical, angiographic and histologic results.

OBJECTIVES: The safety and long-term results of directional coronary atherectomy in stented coronary arteries were determined. In addition, tissue studies were performed to characterize the development of restenosis. METHODS: Directional coronary atherectomy was performed in restenosed stents in nine patients (10 procedures) 82 to 1,179 days after stenting. The tissue was assessed for histologic features of restenosis, smooth muscle cell phenotype, markers of cell proliferation and cell density. A control (no stenting) group consisted of 13 patients treated with directional coronary atherectomy for restenosis 14 to 597 days after coronary angioplasty, directional coronary atherectomy or laser intervention. RESULTS: Directional coronary atherectomy procedures within the stent were technically successful with results similar to those of the initial stenting procedure (2.31 +/- 0.38 vs. 2.44 +/- 0.35 mm). Of five patients with angiographic follow-up, three had restenosis requiring reintervention (surgery in two and repeat atherectomy followed by laser angioplasty in one). Intimal hyperplasia was identified in 80% of specimens after stenting and in 77% after coronary angioplasty or atherectomy. In three patients with stenting, 70% to 76% of the intimal cells showed morphologic features of a contractile phenotype by electron microscopy 47 to 185 days after coronary intervention. Evidence of ongoing proliferation (proliferating cell nuclear antigen antibody studies) was absent in all specimens studied. Although wide individual variability was present in the maximal cell density of the intimal hyperplasia, there was a trend toward a reduction in cell density over time. CONCLUSIONS: Although atherectomy is feasible for the treatment of restenosis in stented coronary arteries and initial results are excellent, recurrence of restenosis is common. Intimal hyperplasia is a nonspecific response to injury regardless of the device used and accounts for about 80% of cases of restenosis. Smooth muscle cell proliferation and phenotypic modulation toward a contractile phenotype are early events and largely completed by the time of clinical presentation of restenosis. Restenotic lesions may be predominantly cellular, matrix or a combination at a particular time after a coronary procedure.

Actins↗
PubMed1992

Verapamil-induced secondary erythermalgia.

A 59-year-old man developed red, swollen and warm feet accompanied by intermittent burning pain during treatment for cardiac failure and arrhythmias with several drugs including verapamil. The condition gradually worsened until there was persistent disabling burning pain and severe erythema and swelling of the feet. Aspirin and other analgesics were ineffective in relieving the discomfort. Histopathology of punch biopsies showed a mild perivascular mononuclear infiltrate and moderate perivascular oedema. Within 2 weeks of stopping verapamil the burning pain, erythema, and swelling of the feet had resolved. The clinical features and subsequent course are consistent with a diagnosis of erythermalgia secondary to verapamil.

Erythromelalgia↗
PubMed1992

Morphodynamic response of the rat light pinealocytes to an injection act. Implication of beta-adrenoreceptors.

The implication of beta-adrenoreceptor-mediated noradrenalin action on the reactive morphodynamic response of light pinealocytes (LP) to an injection act, conceived as a short-lasting stress attack, is reported. An injection act, realized by saline-injection, was manifested in the occurrence of clustered "dusk" and "bright" cells--the representative forms of functionally activated LP. The time-related incidence of these cells entities--the appearance of "dusk" and "bright" cells at 5 min, transitory domination of "bright" cells and the nadir of "dusk" cells at 20 min, sporadic recognition of "bright" cells, lack of "dusk" cells at 45 min and the absence of both cell forms at 180 min--displayed that LP-reactive response promptly appeared and rapidly ceased. The injection of beta-adrenoreceptor antagonist, propranolol, did not considerably alter the pattern of LP-reactive response proper for saline-injected rats at 5 min. The constant presence of "dusk" and "bright" cells, structurally changed in all the following time periods under investigation, showed that this drug disordered the course of LP-reactive response to an injection act. On the contrary, LP of resting state was not found to be affected. Estimating functionally, the present results indicate that beta-adrenoreceptor-mediated noradrenalin action is required to promote, maintain and accomplish the LP-reactive response to a short-lasting stress inducement.

Animals↗
PubMed1991

Calcinosis cutis, osteoma cutis, poikiloderma and skeletal abnormalities (COPS syndrome)--a new entity?

A 4-year-old boy with subcutaneous tumours is described. These tumours were calcified and had secondary osteoma formation. In addition the patient showed poikiloderma on the face and less prominently on arms and legs. X-ray films of the distal metaphyses of the radius, ulna and tibia revealed irregular mineralisation. Repeated laboratory tests revealed no abnormalities of fat, bone and mineral metabolism. This patient showed a unique combination of symptoms. We propose to call this syndrome: COPS-syndrome (Calcinosis cutis, Osteoma cutis, Poikiloderma and Skeletal abnormalities).

Bone Neoplasms↗
PubMed1991

Benign persistent papular acantholytic and dyskeratotic eruption: a case report and review of the literature.

We report a case of a 35-year-old female with a persistent pruritic acantholytic and dyskeratotic eruption on the chest and vulva. The light and electron microscopic studies showed suprabasal epidermal clefting with acantholysis and dyskeratotic cells. We suggest that the most appropriate term for this case is that of benign persistent papular acantholytic and dyskeratotic eruption.

Adult↗
PubMed1991

Bullous pemphigoid in children. Report of three cases with special emphasis on therapy.

Three children aged 4 months, 7 years, and 12 years, had bullous pemphigoid (BP). Two children suffered from disseminated BP and one (12 years) from vulvar localized BP. This last form has been described only once before in a girl. The various forms of pemphigoid in childhood are rare and reported in only about 40 instances. Bullous pemphigoid in childhood does not differ clearly from the adult counterpart, although lesions of the mucous membranes seem more common in childhood.

Adolescent↗
PubMed1991

Diffuse cutaneous mastocytosis mimicking staphylococcal scalded-skin syndrome: report of three cases.

Three cases of diffuse cutaneous mastocytosis (DCM) were at first incorrectly diagnosed as staphylococcal scalded-skin syndrome. In the first patient, at age 1 day the disease was recognized promptly by simple techniques such as Darier's sign and Tzanck smear. Much delay in making the diagnosis occurred in the other two patients, however: almost 1 year and 15 years, respectively. Bullous manifestations in mastocytosis occur only in the first two or three years. In the first months the disease can be dangerous and life threatening. To distinguish mastocytosis from vesicular and bullous neonatal disorders, one should perform Darier's sign and a Tzanck smear. The diagnosis is confirmed by histopathologic studies. Treatment of the bullous manifestations is symptomatic, with zinc oxide paste and oral antihistamines, which may provide some relief. In addition, cimetidine and sodium cromoglycate may be beneficial. At a later age psoralen plus ultraviolet A therapy may also relieve the symptoms. Particular foods and medicines can liberate histamine and should be restricted as much as possible in extremely affected patients. Special care should be taken when these patients are to undergo anesthesia. The risk of complications during and after anesthesia is also present in other forms of mastocytosis.

Adolescent↗
PubMed1991

Ultrastructural aspects of infection with Treponema pallidum subspecies pertenue (Pariaman strain).

OBJECTIVE: To study ultrastructural aspects of infection with Treponema pertenue (Pariaman strain), originating from West Sumatra, Indonesia. MATERIALS AND METHODS: Biopsy material originating from skin lesions in ten young children suffering from early infectious yaws in Indonesia, and rabbit testicular tissue inoculated with T pertenue. Human skin as well as rabbit testicular tissue was examined by means of conventional electron microscopy. RESULTS: In human skin, treponemes were found in interepidermal spaces in 5 out of 10 specimens. In two of five positive specimens, treponemes were also seen in the dermis. In one out of five specimens from rabbit testicular tissue a profusion of treponemes was found lying in the interstitial myxomatous tissue. Microorganisms showed no adhesion to fibroblasts. CONCLUSION: This ultrastructural study of T pertenue demonstrated the scarcity and focal distribution of treponemes in tissue and did not reveal any morphological differences from the Gauthier strain of T pertenue. No differences from the ultrastructure of T pallidum were observed either.

Animals↗
PubMed1991

Ichthyosis, exocrine pancreatic insufficiency, impaired neutrophil chemotaxis, growth retardation, and metaphyseal dysplasia (Shwachman syndrome). Report of a case with extensive skin lesions (clinical, histological, and ultrastructural findings)

The Shwachman syndrome comprises exocrine pancreatic insufficiency, growth retardation, and bone marrow hypoplasia resulting in neutropenia. Clinical, morphological, and ultrastructural studies, as well as hair analysis, were performed in a patient with Shwachman's syndrome and severe ichthyosis. Clinical findings were lamellar ichthyosiform desquamation on the extremities. The hair was scanty and short on the scalp, in the eyelashes, and in the eyebrows. The nails were hyperkeratotic. Morphologic findings were slight, regular acanthosis and severe diffuse hyperkeratosis with variable parakeratosis. The granular layer was thickened. The papillary dermis showed very slight perivascular lymphocyte infiltration. The most prominent ultrastructural finding was the presence of solitary or multiple droplets of varying size in the cytoplasm of the keratinocytes. Hair analysis revealed no abnormalities; the cystine concentration in hair specimens was normal.

Bone Diseases, Developmental↗
PubMed1990

Purpuric contact dermatitis to benzoyl peroxide.

Patch test reactions in a patient with purpuric contact dermatitis to 5% benzoyl peroxide are described. Alterations of the capillary endothelium included obliteration of the lumina with perivascular mononuclear cell infiltrates. There were no epidermal alterations. These observations are discussed with reference to the data in the literature on vascular damage in "dermal" contact dermatitis.

Adult↗
PubMed1990

Synergistic immunosuppressive effects of monoclonal antibodies specific for interferon-gamma and tumor necrosis factor alpha. A skin transplantation study in the rhesus monkey.

Interferon gamma and tumor necrosis factor alpha play a significant role in the upregulation of host immunity and inflammation, for example by induction and enhancement of the expression of major histocompatibility complex class I and II antigens on a wide variety of cell types, both in vitro and in vivo. In this study two crossreactive monoclonal antibodies, one specific for human IFN-gamma (MD1), the other specific for human TNF-alpha (61E71), were tested for immunosuppressive potencies in a skin transplantation study in the rhesus monkey. Treatment with either MD1 or 61E71 alone did not prolong skin-graft-survival times. In combination, however, these antibodies augmented graft survival times significantly. Infiltration of the skin grafts by lymphocytes and histiocytes was delayed, and upregulation of MHC class I and II expression was retarded. This is the first reported demonstration of a synergistic effect of mAbs specific for IFN-gamma and TNF-alpha in the suppression of allograft rejection in primates.

Animals↗
PubMed1990

Early yaws: a light microscopic study.

This paper presents the light microscopic findings in biopsies of skin lesions from 45 patients, in whom a diagnosis of early yaws was suspected. In 27 cases typical light-microscopic features of yaws were observed, consisting of parakeratosis or crust containing exudate, marked acanthosis with widening and elongation of the rete ridges or pseudo-carcinomatous hyperplasia and spongiosis. Intraepidermal microabscesses consisting of polymorphonuclear leucocytes were frequently encountered. In a large majority a moderate to dense infiltrate was present, composed mainly of lymphocytes and plasma cells. Vascular changes consisted of only slight endothelial cell proliferation and thickening of vessel walls. Steiner staining revealed the presence of treponemes in the epidermis in 23 of 27 cases. Remarkably, clusters of treponemes were also seen in the papillary dermis in three out of 23 cases. Seven other cases were strongly suggestive of yaws. Other histopathological diagnoses were made in 6 patients, due to the simultaneous occurrence of other skin diseases. The remaining five specimens did not contain enough tissue to allow conclusions to be made.

Adolescent↗
PubMed1990

Solitary malignant Schwannoma: clinical aspects, immunohistochemistry and ultrastructure.

Solitary malignant Schwannoma is a rare tumor derived from cells of the nerve sheath, the Schwann cells. During the past 6 years we have treated six patients with this tumor, four males and two females ranging in age from 18 to 69 years. Five of them had their tumors located on the trunk, which is associated with a bad prognosis. In four of the six patients ultrastructural examination played an important role in making the diagnosis of malignant Schwannoma. Light microscopy alone is insufficient because the spindle-shaped cells growing in fascicles often closely resemble other sarcomatous tumors. Ultrastructural typical findings of Schwannomas are cytoplasmic processes, intercellular junctions and basal lamina. Surgery was the sole treatment in three patients. One patient only received chemotherapy because of disseminated disease. The other two were treated with surgery combined with radiotherapy. Four patients developed distant metastases for which chemotherapy was given, but all patients died within 3 years after their initial treatment. Only two patients are free of disease 56 and 72 months after treatment. Solitary malignant Schwannoma is a tumor with a grave prognosis, for which ultrastructural and immunohistochemical examination plays an important role in order to establish the diagnosis.

Adult↗
PubMed1990

General perianal skin problems.

In this paper attention is focused on the following conditions: perianal skin problems such as pruritus in the perianal area, the eczemas, psoriasis, premalignant and malignant tumours such as Bowen's disease and Bowenoid papulosis, squamous cell carcinoma, dermatophyte and yeast infections and sexually transmitted diseases such as syphilis, condylomata acuminata (warts) and genital herpes. Principles of clinical, bacteriological and histopathological diagnosis will be discussed briefly for each of the above-mentioned diseases. For some of these, therapeutic effectiveness and particular side effects due to the use of topically applied drugs containing corticosteroids, anaesthetics, antibiotics and preservatives will also be considered.

Anal Canal↗