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Biomedical subjects

V D Moskalenko

Publications and source records attributed to V D Moskalenko.

At least 19 recordsLinked to original sources
PubMed2001

[Anticipation in the families of patients with alcoholism and drug addiction (son-father dyads)].

The clinical pattern of psychoactive drug addiction (PDA) was investigated in 41 father-son dads. Seven clinical characteristics were taken into consideration: The age at the onset of systematic PDA abuse; the rate of addiction development; the severity of the withdrawal syndrome; rate of progression, the form of drug abuse; the duration and quality of remissions; somatoneurologic consequences; and the clinical picture as a whole. These characteristics was evaluated in the members of each dad in terms of more or less severity. There is a strong tendency for more severe clinical picture in sons as compared with their fathers. The findings support the hypothesis that there is anticipation in the representatives of two generations of the families with drug dependence.

Adolescent↗
PubMed1997

[Mental disorders in the offspring of alcoholic fathers (children from an early age to 28)].

The examined groups included 175 children whose fathers were alcoholics and 73 individuals from nonalcoholic parents. The study group was divided by age into children from infantile age to 15 years and 16-28-year-olds. The wide range of psychopathologic disorders were revealed in children up to 15 years of age: syndrome of hyperactivity, neurotic disturbances, mental retardation, epileptic-like syndrome. Alcoholism was found in sons only (3.77%). Mental disorders were revealed significantly more frequently in sons of alcoholic fathers than in their daughters. Their incidence increased with the age of the sons. The disturbances occurred significantly more frequently in the test group as compared with the control one (19 and 6.38%, respective by). In the older group (16-28-year-olds) the spectrum of mental disorders consisted of alcoholism, mental retardation, psychopathic-like and neurotic disorders. Alcoholism occurred most frequent and its rate depended on the age and sex. Frequency of alcoholism was 66.7% in sons aged 21-28 years and 15.38% in daughters of the same age. The conclusion was made about multiple risk for children of alcoholic fathers. More vulnerable contingent was the sons for which the risk of alcoholism was very high.

Adolescent↗
PubMed1994

[The wives of alcoholics: experience in the study of psychopathology].

The authors examined clinically 215 wives of alcoholics or divorced women who had been previously married to alcoholics. None of the women abused alcohol. Only 12 of them were officially registered as psychiatrist's patients. Borderline psychopathological conditions were diagnosed in 174 women who had long been married to alcoholic husbands or lived with them in one apartment. Of them, psychopathy, neurotic personality, neurosis, reactive depressions were identified in 27%, 24.7%, 23%, 15%, respectively. 41 divorced women living apart from former alcoholic husbands had no psychopathology at the moment of the study. Borderline neurotic disorders in alcoholic husbands' wives should be considered in familial analysis made for subjects seeking genetic advice.

Adjustment Disorders↗
PubMed1993

[The husbands of alcoholic women: experience in studying the psychopathology].

The familial and personal histories and present status of 41 married couples with the family pattern wherein the wife was alcoholic and the husband was non-alcoholic were clinically studied. The purpose was to study the incidence and nature of psychopathological disorders in males in this marriage. It was found that 8 males who were divorced and had been married to an alcoholic female showed no mental disorders at the moment of the study. The remaining 33 husbands living with their alcoholic wife had borderline mental disorders. The diagnostic assessment of the detected disorders was the following in order of decreasing: neuroses, psychopathies, neurotic development of a personality. The high incidence rates of borderline psychopathological disorders in the husbands of alcoholic females suggest that aid should be rendered to the whole family rather than an alcoholic alone.

Adult↗
PubMed1992

A genetic study of alcoholism in the Moscow population: preliminary findings.

This article reports the preliminary results of a family study of alcoholism in the Moscow population. A comparison of male and female alcoholic inpatients revealed differences between them in the patterns of alcoholism development and in the frequencies of the disorder among male and female probands' parents and siblings. Those differences, particularly those observed in the fathers of the female and male probands, may suggest that the liability and genetic predisposition to alcoholism in female alcoholics, on the average, are higher than those in male alcoholics. There were also differences between male and female probands in the frequencies of the types of drinking behavior (including alcoholism) we used to characterize individual phenotypes as to the liability to alcoholism in the probands' parents and spouses, indicating that the higher the liability and/or genetic predisposition to alcoholism the higher the probability of the proband's marriage to an individual with a higher liability to the disorder. The data on the comparison of the probands' children with their parents affectedness imply the possibility of a relationship between the genetic predisposition to alcoholism and the risk for mental and somatic disturbances in offspring of alcoholics.

Adult↗
PubMed1987

[Alcoholism and heredity: biological basis of the predisposition to alcoholism].

Authors critically review current data about biochemical-physiological factors mediating genetic predisposition to alcoholism. Results of genetic investigation of the ethanol and acetaldehyde metabolism and the facts about enzyme polymorphism of systems of the ethanol biotransformation and genetic polymorphism of particular enzymes are summarized. Data about possible determinants of nervous system sensitivity to ethanol action are considered. The investigation of genetic basis of phenomena imminent to alcoholism by use of laboratory animals is discussed.

Alcoholism↗
PubMed1981

[Relationship between the clinical and electroencephalographic features of similarities between schizophrenic twins and the patient's sex].

Clinical and electroencephalographic peculiarities in monozygotic (15 pairs) and dizygotic (28 pairs) twins suffering from schizophrenia were studied. In addition to the traditional comparison of the mono- and dizygotic twins as regards the clinical and encephalographic similarities and differences in each pair of them, peculiarities of male and female pairs of the twins were also compared (in each group). A tendency to a greater variability of the characteristics examined was revealed among the female twins.

Diseases in Twins↗
PubMed1980

[Interpair differences in the characteristics of the ontogeny, premorbid personality and severity of schizophrenia in twins].

In each of the studied 124 pairs, a twin A was distinguished (the patient with manifest symptoms in the discordant pairs, or more seriously affected twin in concordant pairs) and twin B--its partner. It was demonstrated that the order of birth, differences in the weight at birth, periodization of development do not correlate with the differences in the clinical expression of schizophrenia. Such unfavourable factors as asphyxia, complications during delivery, severe somatic illnesses had a certain tendency to accumulate in twin A. The most distinct correlation was found between the traits of a premorbid personality and the eventual intrapair differences in the severeity of schizophrenia. Twin A in the majority of the cases was more excitable in childhood, had more fears, slept worse, and had a poor appetite. The twin A by its premorbid traits was generally characterized by prevalent asthenic features, withdrawal signs and a more dysharmonic type of personality.

Asphyxia Neonatorum↗