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Biomedical subjects

V Costa

Publications and source records attributed to V Costa.

At least 55 records · Page 3Linked to original sources
PubMed1990

Copper distribution within and between newborn livers.

Copper concentration was determined in different liver samples (blocks, needle biopsy and bile) obtained from 9 newborns and 3 infants at autopsy. Tissue blocks, sampled at ten equally spaced intervals between the left and the right lobe, revealed in newborns high copper concentrations, ranging from 93 to 335 mg/Kg of dry tissue with an upward trend from the right to the left lobe. The situation differed in infants where a lower and more evenly distributed copper content, ranging from 49 to 123 mg/Kg of dry tissue, was found, which seemed to approximate the situation found in adults. Copper concentration was generally high in bile, with an overall range from 99 to 413 mg/Kg of dry material. This fact was particularly significant in infants, considering their low hepatic copper content. Copper content determined in percutaneous biopts was significantly correlated to (P less than 0.01), though only moderately predictive of (r2 = 0.54), the average copper content calculated from the ten liver blocks.

Bile↗
PubMed1986

Viminol R2 analgesic activity in patients with postoperative pain: comparison with pentazocine.

The analgesic activity of Viminol R2 was compared to that of Pentazocine and placebo in a double-blind, "between subjects" study involving 42 patients with postoperative pain randomly assigned to 3 groups of 14 patients each and treated with a single intravenous dose of Viminol R2 10 mg, Pentazocine 30 mg or placebo. Pain relief scores were recorded over a 2 h period after treatment. The analgesic activity of Viminol R2 and Pentazocine was significantly greater than that of placebo both in terms of time-course of action and frequency of classes of satisfactory analgesia. No statistically significant differences were found between Viminol R2 and Pentazocine. No side effects were observed in any patients treated with Viminol R2.

Adult↗
PubMed1983

[Experience with preoperative preventive care in obstetrics and gynecology].

The clinical behaviour and post-operative course of 60 patients who had undergone obstetrics or gynaecological surgery is compared. In 30 cases (20 obstetric and 10 gynaecological), antibiotic prophylaxis took the form of a single i.m. injection of 600 mg of lincomycin and 80 mg of gentamycin, 30 minutes before the operation. In the remaining 30 cases (20 obstetric, 10 gynacological), the antibiotic cover was administered postoperatively by i.v. injection of doxicyclin (100 mg every 12 hours for 3 days and 100 mg every 12 hours per os for a further 2 days). From a comparison of the 2 groups, and keeping obstetric and gynaecological cases separate, it is concluded that preoperative antibiotic prophylaxis is comparable in its results to post-operative antibiotic cover. Postoperative haematochemical tests were also done and, as has been reported, showed no significant alterations from the tests administered preoperatively, thus confirming the high tolerance of the drugs in question in the above-stated doses. No cochleovestibular disturbances were encountered nor were drug-resistant bacteriological strains. The efficacy of this prophylactic treatment is confirmed and though comparable in results to the alternative postoperative types is indubitably advantageous both in the lower cost to the community and the short duration of the treatment itself.

Adult↗