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Biomedical subjects

V Chernick

Publications and source records attributed to V Chernick.

At least 145 records · Page 8Linked to original sources
PubMed1967

Correlations of mechanical stability, morphology, pulmonary surfactant, and phospholipid content in the developing lamb lung.

Pressure-volume characteristics and surface tension measurements of the lamb of 120 to 130 days gestational age were typical of the mature lung in the upper lobes and the immature lung in the lower lobes. By term both upper and lower lobes had findings characteristic of the mature animal. Phospholipid concentration per milligram DNA and per cent saturated fatty acids on pulmonary phosphatidyl choline were relatively constant from 60 to 120 days gestational age; thereafter there was a significant increase in both measurements. These changes usually coincided with an increase in osmiophilic inclusion bodies in the large alveolar cell.A concentration of disaturated phosphatidyl choline per milligram DNA in excess of 0.170 mg per mg was associated with a minimal surface tension below 13 dynes per cm (p < 0.001). Newborn animal lungs contained over 3 times this critical concentration, whereas adult lungs contained 1.5 times this value. The excess disaturated phosphatidyl choline per milligram DNA may represent a reservoir of pulmonary surfactant.

Animals↗
PubMedDate not supplied

Endogenous opiates and response to exercise in asthmatic children and adolescents.

Whether endorphins secreted during stressful exercise may play a role in the physiologic response of asthmatics was investigated. Thirteen asthmatic subjects were studied: seven (mean age 16 years +/- 2.8 SEM) had perennial asthma and exercise-induced bronchospasm (EIB), and six (mean age 18 years +/- 2) had mild seasonal asthma without EIB. Each subject performed two matched progressive exercise challenges on consecutive days. Baseline lung function was measured before each challenge and was measured again after exercise at regular intervals for 30 minutes. One minute before exercise each subject received intravenously either i.v. naloxone (0.04 mg/kg), an opiate receptor blocker, or saline, in a double-blind crossover fashion. Heart rate, oxygen consumption, minute ventilation, tidal volume, and arterial oxygen saturation were recorded throughout the tests. During the two challenges these parameters were not significantly different for all 13 patients. The mean percentage reduction in FEV1 after exercise for the seven subjects with EIB was slightly but not significantly less with naloxone (25% +/- 7 SEM) than with placebo (32% +/- 7) during the first 10 minutes after exercise. Naloxone had no obvious effect on EIB or the other parameters measured in association with strenuous exercise in asthmatic patients.

Adolescent↗
PubMedDate not supplied

Recurrent thoracic duplication cyst with associated mediastinal gas.

Mediastinal cysts are not uncommon in the pediatric age group. Presentation varies from an abnormality found on routine chest radiograph to severe respiratory distress and even respiratory failure. Presentation depends on the age of the patient, the location of the lesion, the extent and the size of the mass, and what structures are involved. The case of a six-year-old boy who presented with recurrence of a mediastinal mass associated with gas two years after surgical removal of an infected esophageal duplication cyst is described. No connection between the cyst and the esophagus to explain the presence of gas was documented. This appears to be the first reported case of esophageal duplication cyst associated with mediastinal gas.

Child, Preschool↗