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Biomedical subjects

V Carter

Publications and source records attributed to V Carter.

25 records · Page 2Linked to original sources
PubMed1984

Chronobiological study of plasma exudation in carrageenan-paw oedema in the rat.

The time-courses of exudation of protein-bound Evans' blue and of the formation of oedema following the injection of carrageenan (2 mg) or normal saline in the rat hind paw at 10.00 hours and 21.00 hours were studied. During the first 90 min after the carrageenan injection, the tissue content of the dye and the oedema formed were much greater when the inflammatory agent was administered at 21.00 hours than at 10.00 hours. A second study carried out at every 3 hours of the 24 hour span showed the presence of a circadian rhythm in the exudation of protein in the paw and in the formation of oedema. The paw volume and content of the dye were found to be highest between 19.00 hours and 01.00 hours whereas the minimal values were obtained at 16.00 hours. There is a correlation between the exudation of plasma proteins and the formation of oedema.

Animals↗
PubMed1978

Pharmacokinetics and disposition of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent, in rat and monkey.

14C-Labelled 1-(2,6-dimethylphenyl)-3-methylamidinourea hydrochloride (14C-WHR-1142A, lidamidine hydrochloride) was rapidly and quantitatively absorbed from the gastrointestinal tract of rat and monkey after a single oral dose of 5 mg/kg (base). Peak 14C levels occurred within 30 min and the radiolabel was found in both the plasma and cellular components of whole blood. The half-life of the parent compound was 30 min in rat and 1 h in the monkey. The label was essentially cleared from all tissues examined within 24 h in the rat. In both rat and monkey, the compound was extensively metabolized (greater than 90%) prior to excretion and eliminated primarily in the urine (95% of the 14C dose could be accounted for in urine within 24 h in the monkey and 65% within 24 h in the rat); about 15-20% of the dose was recovered in feces within 24 h in the rat. In rat, a significant portion of the dose was eliminated in bile, and enterohepatic recirculation of 14C excreted in bile occurred. In contrast, biliary elimination of 14C was not a major pathway in the monkey.

Amidines↗
PubMedDate not supplied

Case management: the relationship between structure & environment.

In response to increasingly uncertain practice environments, case management structural dimensions of role differentiation, task coordination, and decentralization remained constant, while nurse participation in decision making increased significantly.

Decision Making, Organizational↗
PubMedDate not supplied

A cost-effectiveness analysis of acute care case management outcomes.

Case management was more cost effective in a moderately uncertain practice environment than in either a low or a high uncertainty environment. The environmental state, case manager role differentiation, and information coordination contributed most strongly to these outcomes.

Cost-Benefit Analysis↗
PubMedDate not supplied

Environmental uncertainty: implications for practice model redesign.

Analysis of one academic medical center revealed three distinct nursing practice environments distinguished by increasing levels of complexity, change, unpredictability, and uncertainty. Designing practice models to accommodate these conditions will facilitate more efficient and effective patient outcomes.

Academic Medical Centers↗