Radiation-induced alterations in succinate dehydrogenase activity in the muscle of pigeon.
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Biomedical subjects
Publications and source records attributed to V C Shah.
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The incidence of supernumerary chromosomes has been frequently observed in one of the subspecies of Indian bush rat, Golunda ellioti gujerati Thomas 1923. Their number varied from 1 to 4 with consistent number of supernumeraries in each individual specimen. A possible explanation is given towards the origin of supernumerary chromosomes in Golunda ellioti gujerati. Two acrocentric chromosomes can give rise to a single large acrocentric and a supernumerary chromosome. This can happen by separation of centromere from one of the acrocentrics and translocation of the centric arms to the telomeric region of the second chromosomes, thus to form large acrocentric leaving the centromeric fragment as supernumerary chromosome.
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The histochemical changes in succinate dehydrogenase (SDH) were investigated in pectoralis major muscle of guinea pig, rat and mouse after low level X-irradiation (72 R and 240 R) and compared with control animals. Biochemical studies were carried out on liver, kidney, muscle (pectoralis major), adrenal and spleen of these animals after low dose local X-irradiation and compared with control animals. Changes in SDH activity were studied up to 72-h post-irradiation, which shows that low dose local X-irradiation leads to increased enzymic activity. The increase in enzymic activity was remarkable in mouse tissues as compared with guinea pig and rat. Adrenals of all the three animals showed significant activation after all the doses of radiation studied. The significance of these results, with special reference to oxidative metabolism, has been discussed.