25-Hydroxyvitamin D2 and 25-hydroxyvitamin D3 as measured by liquid chromatography and by competitive protein binding.
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25-Hydroxyvitamin D 2↗
Biomedical subjects
V Butler
Publications and source records attributed to V Butler.
Glial changes in the progress of a chemical lesion. An electron microscopic study.
The response of non-neuronal cells in the brain to monosodium glutamate (MSG) was studied in the neonatal mouse brain. Neurons rapidly degenerate in this chemically-induced lesion, and the glia reflect and respond to their early pyknosis and death. Astrocytic glia exhibit the most profound responses in the form of degenerative nuclear and cytoplasmic changes within 15 to 20 minutes after ingestion of MSG. After 6 to 12 hours, a large glial cell population, containing neuronal and synaptic debris, can be seen. Recovery of severely damaged astrocytes is unlikely. Further, evidence of multiplication of uninjured cells to supply this observed repopulation was found. Microglia start to engulf debris at 6 to 12 hours and continue this process through at least 48 hours. From 3 to 48 hours, a third cell type, tentatively identified as a Gitter cell, is preminently involved in phagocytosis of neuronal elements. Nuclei of these cells enlarge and their parikarya become vastly expanded in a fashion typical of Gitter cells. These cells appear to represent the transformed microglia. Phagocytosis following a chemical lesion induced by glutamic acid, a neurotransmitter substance, is exceedingly rapid in comparison to that elicited by other types of lesions. Further, endogenous glial cells cope with the cellular debris; no participation in this process by hematogenous cells was observed.
Animals↗
Hypothalamic morphology following ingestion of aspartame or MSG in the neonatal rodent and primate: a preliminary report.
Neonatal mice received oral doses of monosodium glutamate (MSG) at levels of 0.25, 0.5m 1.0, 2.0, and 4.0 g/kg or aspartame at levels of 0.5, 1.0, 1.5, and 2.0 g/kg. Hypothalamic lesions were encountered at dose levels equal to or exceeding 0.5 g/kg (MSG) and 1.0 g/kg (aspartame). Aspartame administration resulted in a much smaller hypothalamic lesion than did equal dosages of MSG. Infant monkeys received MSG (1-4 g/kg) or aspartame (2 g/kg) by stomach tube. Hypothalamic morphology remained normal at both the microscopic and ultrastructural level. Thus, in contrast to the neonatal rodent, the neonatal primate is able to cope either metabolically or at the level of the blood-brain barrier with excessive amino acid loads.
Animals↗
Brain damage in neonatal mice following monosodium glutamate administration: possible involvement of hypernatremia and hyperosmolality.
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Amygdala↗
Disadvantages in the use of animal serum for quality control of serum iron binding capacity estimation.
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Animals↗
Promoting multiculturalism in healthcare on a zero budget.
When a B.C. health commission proposed strategies for promoting cultural awareness in healthcare, members of one hospital staff took up the challenge. With no budget and in addition to their regular duties, they researched and developed practical tools for healthcare workers in the midst of Victoria's diverse community.
Attitude of Health Personnel↗