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Biomedical subjects

V Briese

Publications and source records attributed to V Briese.

At least 37 records · Page 2Linked to original sources
PubMed1999

[Toxoplasmosis-antibody seroprevalence in Mecklenburg-Western Pomerania].

OBJECTIVE: The aim of this study was to get a general idea of the antibody prevalence of toxoplasmosis within the different agegroups of the population of Mecklenburg-Western Pomerania. 4854 serums (collected between 1994 and 1996) from different institutions of the federal state were investigated with the "Toxo-Competitions Test LTXC)" at the Mini-Vidas divice (bio Merieux). MATERIAL AND METHODS: An antibody prevalence rate of 59% was found. As expected, with rising age a continuing increase was recognisable. The antibody prevalence rate with the male test persons amounted to 58.5%, with the female test persons to 59.3%, and within the pregnant women 63.2%. RESULTS: Therefore 36.8% of pregnant women have got no toxoplasmosis antibodies, i.e. they are exposed to the danger of a primary infection. Within pregnant women aged between 20 and 40 an increase of antibody prevalence of 1% per year of age was recognisable. There was only a small share of pregnant women (10.5%), but they confirm the facts known from literature. CONCLUSIONS: More than 1/3 of our test persons hadn't had toxoplasmosis antibodies. Therefore in order to reduce the danger of a primary infection in pregnant women a screening before pregnancy in recommendable.

Adolescent↗
PubMed1999

[Investigation of adhesion molecules (sVCAM-1) in serum of nonpregnant women, normotensive pregnant women and in patients with pregnancy complications].

OBJECTIVE: An increased expression of endothelial adhesion molecules combined with neutrophil activation in the placental bed is to be assumed aetiopathogenetically relevant in preeclampsia. MATERIAL AND METHODS: Ranges of sVCAM-1 serum concentrations of both control persons (29 nonpregnant and 25 normotensive pregnant women) and patients with different complications of pregnancy (HELLP-syndrome n = 10, preeclampsia n = 12, gestational hypertension n = 38, diabetes n = 24, growth retardation n = 21) were determined by means of ELISA. Frozen placental samples of 5 normotensive and 10 hypertensive pregnant women were investigated immunhistochemically to study the distribution of VCAM-1 in the placenta. RESULTS: Significantly elevated sVCAM-1 serum levels (p < 0.05) were identified in samples of patients with HELLP syndrome, preeclampsia, diabetes and gestational hypertension compared with serum levels of normotensive pregnant women. The cut-off level (97.5% percentile of normotensive serum levels) was calculated (775 ng/ml). VCAM-1 was localized immunhistochemically at capillaries of villi and main villi. CONCLUSIONS: There are closed relations between elevated serum levels of sVCAM-1 during pregnancy and diseases with vasculopathies of placental bed.

Adult↗
PubMed1999

[Determination of reference ranges and effect of maternal and fetal factors on insulin and C-peptide level in umbilical cord blood].

OBJECTIVE: The risks of pregnancy caused by maternal diabetes are well known. Patients with unrecognized gestational diabetes mellitus (GDM) represent a special problem. The aim of our study was to find out, whether the determination of insulin and C-peptide in cord blood serum offers a valuable tool for retrospective analysis. MATERIAL AND METHODS: In 600 paired serum samples from maternal venous blood and neonatal cord blood insulin and C-peptide were determined radioimmunologically. A reference group consisting of 338 mothers and their newborns was established by exclusion of all patients with known pregnancy complications. RESULTS: Positive correlations could be identified between fetal insulin and fetal C-peptide, as well as correlations of these parameters with birth weight and body length, with maternal values of insulin, C-peptide, body-mass index, weight, and weight gain during pregnancy respectively. Increased levels of cord serum insulin were found in complicated pregnancies as well as in patients with previous pregnancy losses, preterm deliveries or stillbirths. CONCLUSIONS: Cord serum insulin and C-peptide were found to be useful parameters for immediate postnatal identification of impaired glucose tolerance during the course of pregnancy.

Adolescent↗
PubMed1997

[Gestational diabetes--perinatal hyperinsulinism and postnatal developmental disorders].

The impaired glucose tolerance in pregnancy (IGT) represents an important fact in aetiopathogenesis of insulin dependent diabetes mellitus (IDDM) and non insulin dependent diabetes (NIDDM) as well as obesitas and cardiovascular diseases in context with fetal hyperinsulinism. Prospective studies of diabetic mothers newborns are difficult by reason of health controls in different outpatient departments. The aim of this review is to claim a general glucose screening in pregnancy looking on the development of newborns in later life. In present preventive prospects were not used to decrease the morbidity in diabetes, obesitas and cardiovascular diseases without gestational diabetes screening in pregnancy. The neonatal onset and late morbidity is dependent on the quality of maternal glycemia in pregnancy measured by means of glycosylated hemoglobin and insulin the amniotic fluid.

Attention Deficit Disorder with Hyperactivity↗
PubMed1995

[Diabetes mellitus--an epidemiologic study of fertility, contraception and sterility].

MATERIAL AND METHODS: Data from 672 female patients with diabetes mellitus between 17 and 42 years of age were collected by questionnaire. Mean manifestation age was 19.9 years (min. 1, max. 38). RESULTS: 72.39% of the patients were treated with insulin; one third had successful pregnancies. Only one of ten diabetics delivered more than once after diabetes had become manifest. At the time of the study, 126 (19.1%) of the patients attempted pregnancy; about one-fifth of these for more than 2 years. Diabetes manifestation occurred significantly earlier in patients who did not achieve conception. Correlation between daily insulin dose and infertility was proved, whereas duration of diabetes had no significant influence on fertility. Habitual abortion was found in 0.62%, among nulliparous patients 1.64%, respectively. Contraception was performed in 64.2% (32.8% hormonal contraceptives, 18.6% IUD, 1.8% natural family planning, 11.0% tubal sterilisation or hysterectomy, 35.8% no contraception). 47% of the used oral contraceptives contained a reduced oestrogen dose (30 micrograms estradiol). In one third of the users, IUD were longer than 5 years in place. Tubal sterilisation was found in 69 (10.44%) of diabetic patients; in 51 cases before the age of 30 years. CONCLUSIONS: Contraceptive methods should be selected carefully. Diabetic patients unsuccessfully attempting pregnancy should be referred early to a centre for reproductive medicine.

Abortion, Habitual↗
PubMed1995

[Current aspects of premature labor].

Six to eight percent of all newborns are born prematurely. Preterm delivery remains the most severe event regarding morbidity and mortality of the premature infants. The most serious complications in the treatment of prematurity are intracerebral bleedings that lead to progressive hydrocephalus and neurological handicaps in those newborns who survive. To our knowledge, about 50% of premature births with cerebral bleedings of stage I-II show normal or slightly decreased postnatal development. Both, a sufficient oxygen utilisation and a regulation of cerebral blood perfusion are necessary to prevent periventricular leucomalacia and cerebral bleedings with impairment of parenchymatous tissue. Endothelial swellings with decreasing blood flow into the cerebral parenchyma were found only in cases of prolonged oxygen deficiency. Vasoconstriction may produce a circulus vitiosus. However, it is important to know that more than 50% of the premature infants probably suffer from initial cerebral bleedings already in the prenatal stage. During the last 10 years the infectious pathogenesis has resulted in better understanding of pathophysiologic factors for prematurity. The local cervical activation of interleukins (IL 1, 6, 8) caused by cervical infections stimulate the prostaglandin synthesis and cervical maturity.

Brain↗
PubMed1995

[Perinatal and neonatal mortality and morbidity in newborn infants up to 1,000 g].

World-wide intensive efforts have been made for more than 20 years to reduce the rate of preterm delivery, but so far without remarkable success. Preterm delivery accounts for 6-9% of all deliveries and very-low-birth-weight infants (< or = 1000 g) total up to about 60% of perinatal mortality. This study reports on a retrospective analysis of fetal outcome with 33 very-low-birth-weight-infants (< or = 1000 g) delivered at the Women's Hospital (University of Rostock) during the time from 1986 to 1992. The rate of early mortality was at 45.2%, survival rate was at 33% (n = 11). Caesarean section with preservation of fetal membranes proved to offer better results of fetal outcome than spontaneous delivery. Comparing the fetal outcome of all patients concerned, it became obvious that newborns whose mothers enjoyed intensive prenatal care had better chances than those newborns whose mothers came to hospital not before onset of preterm labour. From our experiences we conclude that intensive antenatal care with very early assessment of all possible risk factors for preterm labour is the prerequisite to reduce the rate of preterm delivery.

Birth Weight↗
PubMed1995

[Cholesterol, HDL-cholesterol, triglycerides and beta-lipoprotein in diabetic pregnancy].

UNLABELLED: Follow up studies regarding lipid metabolism in diabetic pregnancy are important in maternal and fetal morbidity. OBJECTIVE: With this background it is particularly opportune to consider the difference of cholesterol, triglycerides and HDL-cholesterol of diabetics and nondiabetics in pregnancy. In addition the correlation of lipids to the glycosylated hemoglobin (HbA1), White groups and other clinical parameters is of interest. Attention is given to the comparison of insulin dependent diabetics (IDDM) and gestational diabetes (GDM) in the 3rd trimester. PATIENTS: A diabetic group of 84 patients (IDDM, GDM) was used for the prospective study over a two years period. The lipid metabolism was estimated preconceptionally, during pregnancy and on 7th day after delivery. 36 pregnant healthy women served as controls. The information obtained from each patient was entered into an SPSS data base. Statistical analysis were done by Mann-Whitney U and Kruskall-Wallis test and by means of Pearson's correlation coefficient to correlate with age, parity, body mass index, creatinin, albumiuria, HbA1, blood pressure. RESULTS: There were no any correlations between lipid parameters cholesterol, triglycerides, HDL-C, beta-lipoprotein and HbA1 as well as White groups (Pearson's coefficient). The triglyceride levels were significant lower in diabetic pregnants compared with healthy controls (p = 0.0095; Wilcoxon Test); diabetes: mean = 1,831 mmol/l; min 0.35; max 5.99 and control group mean = 2,133 mmol/l; min 0.36; max 4.70. Cholesterol levels were higher in the 3rd trimester of GDM patients than values of IDDM's (p = 0.0017; Wilcoxon Test). The longitudinal study during diabetic pregnancy resulted in significantly progressive increase in cholesterol and triglyceride levels (p = 0.0035 bzw. p = 0.0099; Kruskal-Wallis Test). CONCLUSIONS: Significant lower triglyceride levels had been found in diabetic pregnants than in healthy controls. There was no any correlation between lipid parameters cholesterol, triglycerides, HDL-cholesterol, beta-lipoprotein on the one side and HbA1 and White groups on the other side. Increased cholesterol levels were noted in the 3rd trimester of pregnancy in the gestational diabetes in comparison of insulin dependent pregnant diabetics.

Adolescent↗
PubMed1995

[Diagnosis and therapy of toxoplasmosis infections in pregnancy at the Rostock University Gynecologic Clinic 1986-1994].

Over a period of eight years, 61 patients with toxoplasmosis infection in pregnancy were examined retrospectively at women's hospital. Diagnosis of maternal infection was based on seroconversion, positive IgM, raising IgG--titers above twofold, and very high primary titers in SFT. In 20 patients (32.8%) diagnosis was found with seroconversion. In 15 patients (24.6%) the first examination revealed very high titers (SFT > or = 1:2000, KBR > or + 1:40)> Using a score, time of infection was grouped into: periconceptional (24.59%), 1st Trimester (34.43%) 2nd Trimester (31.14%), 3rd Trimester (4.92%), not specified (4.92%). The latency phase between first suspect titer and treatment did vary markedly. Duration of latency phase was longer than 6 weeks only in 10% and 20% of cases identified via seroconversion or very high titers respectively. Of all cases with different diagnostic attempts 73.9% were treated later than 6 weeks after the first suspect titer. Therapy was performed with either a combination of pyrimethamine-sulfadiacine or spiramycin monotherapy. In 18/53 newborns (33.9%) fetal infections were proven with IgM-detection post partum. Clinical evaluation was normal in 48 children (77.5%). 6 newborns (9.7%) had dilated cerebral ventricles; 3 (4.8%) had irregularly dense intracerebral structures, one newborn (1.6%) had intracerebral calcifications. Primary neurological check-up of the newborn was normal in 91.9%. 2 children (3.2%) had facial paralysis or reduced muscle tonus. In 2 newborns (3.2%) opthalmological examination of the fundus revealed signs of retino-chorioditis.

Adult↗
PubMed1994

[Fetal outcome after local prostaglandin E2 administration in a risk patient group--comparison of morbidity with a normal patient sample].

Intracervical application of prostaglandin E2 gel is considered to be effective in the induction of cervical ripening (priming). Within an 2-years period 244 perinatal risk patients primed with PGE2 were compared with matched paired controls retrospectively. These 244 controls were matched for age, gestational age, parity, birth weight and maternal body mass index and delivered spontaneously. PGE2 gel (Prepidil) was administered intracervically. Basis criteria of perinatal quality, such as neonatal umbilical cord pH and APGAR-score were significantly (p < 0.01) worse in the patients treated with PGE2 gel. In the priming group cord pH was 7.28 (+/- 0.085) and 7.30 (+/- 0.070) in the control group. APGAR 1 min. was found to be 7.56 +/- 1.86 (priming) and 8.18 +/- 1.23 (control); APGAR 5 min. 8.56 +/- 0.90 (priming) and 8.78 +/- 0.54 (control). Contraction disorders, such as hyperactivity and dyscoordination, combined with cardiotocographic pathology was found in 42% (priming) and 19% (control) resp. Severe bradycardia occurred significantly more often in the priming group, whereas no differences were found concerning fever under labor and in puerperium.

Acid-Base Equilibrium↗
PubMed1994

[Expectant management of premature rupture of fetal membranes before completion of the 35th week of pregnancy--retrospective analysis of 44 cases].

44 cases of preterm premature rupture of fetal membranes (PPROM) before 35 completed weeks of gestation were analyzed retrospectively. Expectative management was based on infection diagnosis, vaginal disinfection and in case of signs of infection on systemic antibiotic therapy. Glucocorticoids for induction of lung maturity were generally administered. Perinatal mortality was 11.4%, after exclusion of one congenital anomaly 9.3% respectively. Lung immaturity was the main cause of neonatal death. Only 5 neonates developed clinical infection, with 4 of these showing prepartal maternal signs of infection. Maternal signs of infection are not a specific signal for later neonatal infection. Cerebral bleeding complications and pathological neurologic status occurred in 10/39 and 8/39 cases respectively. Cesarean section rate amounted to 15/44 (34%).

Adolescent↗
PubMed1994

[Anemia in puerperium--a retrospective analysis].

In 10,393 patients delivered in our hospital between 4/1986 and 8/1992 prevalence of anemia post partum was determined retrospectively. Post partum anemia was classified according to blood hemoglobin content: mild to moderate anemia (6.0-7.0 mmol/l) and severe anemia (< 6.0 mmol/l). After exclusion of patients with high intrapartal blood loss and/or febrile puerperium overall prevalence of anemia increased from 33.78% in 1986 to 49.46% in 1992 (p < 0.01). The portion of patients with blood hemoglobin < 5.4 mmol/l remained stable with 5.6% during observation period. The presented data stress the need for general iron supplementation during pregnancy and puerperium.

Adult↗
PubMed1994

[Analysis of 122 twin deliveries with special reference to morbidity and mortality of the second twin].

122 consecutive twin deliveries between 1986-1992 were analysed retrospectively under special consideration of morbidity and mortality of the second twin. 13.9% of the twin deliveries occurred before the 33rd week of gestation. The cesarean section rate amounted to 49.2%, the first twin was delivered in 5.7%, the second twin in 27%, by vaginal operative methods. Perinatal mortality of the first twin was 3.3%, of the second twin 6.6% (p < 0.01); thus resulting in an overall twin mortality rate of 4.9%. The acidosis-rate of 16.4% in the second twin was significantly above the 9.0% in the first twin. The vaginal operative mode delivery especially contributed to the impaired outcome of the second twin. There was no correlation between the morbidity of the second twin and the time interval between the two deliveries.

Adolescent↗
PubMed1994

[Thrombocytopenia in pregnancy--a case report].

A report is given on a rare case of a 25 years old pregnant women with hepatosplenomegaly, thrombocytopenia and elevated liver enzymes. Because of an abnormality of the Truncus coeliacus and A. mesenterica superior and portal hypertension there has been performed the end-to-side portocaval anastomosis.

Adult↗
PubMed1993

Semiquantitative determination of IL-1 alpha, TNF-alpha, PDGF-A, PDGF-B, and PDGF-receptor in term human placenta using polymerase chain reaction (PCR).

Eight placenta samples derived from normal term human placenta were examined for the expression levels of Il-1 alpha+, TNF-alpha+, PDGF-A+, PDGF-B+, and PDGF-receptor+ using a semiquantitative PCR protocol. The expressional level of beta-actin was proven to be constant, therefore beta-actin could serve to equilibrate sample size in our procedure. Differences were found in the mRNA levels of IL-1 alpha and TNF-alpha. The expression of PDGF-A, BDGF-B and PDGF-R seemed to be relatively constant in our group of samples. Further investigation and improved quantitative PCR protocols are needed to correlate clinical outcome of pregnancy with cytokine expression at the placental level. +Il-1 alpha (interleukin-1 alpha) +TNF-alpha (tumor necrosis factor-alpha) +PDGF-A (platelet derived growth factor A) +PDGF-B (platelet derived growth factor B) +PDGF-Rezeptor (platelet derived growth factor-rezeptor).

Actins↗