Search PubMed⌕ Search

Biomedical subjects

V Boix

Publications and source records attributed to V Boix.

At least 37 records · Page 2Linked to original sources
PubMed1997

Abnormalities in the metabolism of acetaminophen in patients infected with the human immunodeficiency virus (HIV).

The urinary concentration of acetaminophen and its glucuronide, sulphate, cysteine, and mercapturate conjugates was measured by high-performance liquid chromatography in 32 healthy volunteers, 9 untreated symptom-free HIV-seropositive subjects, and 19 patients with AIDS after a single oral dose of 1.5 g of acetaminophen. The concentration of the glucuronide conjugate was significantly lower in AIDS patients when simultaneously compared with concentrations found in healthy individuals and symptoms-free HIV-seropositive subjects. Differences between healthy volunteers and symptom-free HIV seropositives were not encountered. By contrast, urinary concentrations of sulphate and oxidation pathway-derived metabolites were significantly higher in AIDS patients as compared with the other two groups. When AIDS patients treated with zidovudine were compared with those not given this medication, differences in the urinary excretion of acetaminophen and its metabolites were not observed. However, the urinary concentration of mercapturic acid was significantly higher in those given enzyme inducers, such as rifampicin or phenytoin, than in AIDS patients not treated with these drugs. In summary, patients with advanced HIV infection showed reduced acetaminophen glucuronidation and increased formation of the hepatotoxic oxidation metabolites, which was independent of zidovudine therapy.

Acetaminophen↗
PubMed1995

[Acute pancreatitis. A prospective epidemiological study in the province of Alicante. A Hospital Group for Study of Digestive Diseases in Alicante].

OBJECTIVE: To gather epidemiological data on acute pancreatitis (AP) in Alicante area. EXPERIMENTAL DESIGN: A prospective study of patients admitted to all public hospitals with AP during 1991. PATIENTS: Patients over 14 years, with elevation of serum amylase and a consistent clinical presentation, or in whom AP was confirmed at laparotomy or postmortem. RESULTS: We identified 473 episodes of AP in 450 patients (236 males and 214 females). The mean age was 59.4 years. The annual incidence was 451 per million habitants/year. The commonest aetiology was biliary (52%) followed by idiopathic forms (24.7%), alcoholic (20.2%) and miscellaneous (2.9%). The overall mortality rate was 5.1%. Male were more frequently affected below 50 years of age (2.4 men/1 woman); the ratio being balanced above this age. Biliary etiology was more frequent in women, (63.5%), while alcoholic forms were more frequent in man (96.8%). 5.1% of patients presented more than one episode of AP during the year analysed. AP involved the 0.58% of the all patients admitted to the hospitals and the 0.14% of the all patients attended in hospital emergencies.

Acute Disease↗
PubMed1994

[The usefulness of different markers in the diagnosis of advanced HIV infection].

BACKGROUND: The aim of this study was to evaluate the usefulness of different markers to diagnose advanced infection by the human immunodeficiency virus (HIV) (AIDS or CD4 lymphocyte < 0.2 x 10(9)/L), establish the degree of correlation and define markers of advanced infection in primary health care. METHODS: Clinical, hematological, biochemical, cellular, serological and immunological variables were analyzed in 146 patients diagnosed for the first time with HIV infection. The patients were classified into three stages: A (II, III, CDC-1987), B (IV-A, IV-C2) and C or advanced (IV-C1, IV-D). The following data were compared: the results in the three stages, the degree of correlation, the specificity and sensitivity to the diagnosis of AIDS. Two multiple logistic regression models were established: the first for all the variables and the second for only those available in primary health care. RESULTS: All the markers except the triglycerides, IgG, IgM, and beta 2-microglobulin presented significant differences in the stages (p < 0.05). With the exception of the CD3+, CD4+ and CD8+ lymphocytes (r > or = 0.6 or -0.6) the remaining variables were independent. The decrease in CD4+ and the increase in neopterin were very sensitive markers (> 95%) but only hyperamylasemia demonstrated a specificity greater than 95% for the diagnosis of advanced infection. Oropharyngeal candidiasis (OR = 4.80) and the CD4+ lymphocyte (OR = 0.99) had the greatest weight in the first model. In the second model the most significant markers were weight loss (OR = 4.41), a decrease in lymphocytes (OR = 7.65) and an increase in IgA (OR = 5.82) with p < 0.01 and a predictive value of 85.16%. CONCLUSIONS: The presence of weight loss, lymphocyte count < 1 x 10(9)/L and an increase in IgA may be used in primary health care to diagnose advanced infection by the human immunodeficiency virus. Asymptomatic hyperamylasemia with no apparent cause suggests advanced infection.

Acquired Immunodeficiency Syndrome↗