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Biomedical subjects

V Blair

Publications and source records attributed to V Blair.

61 records · Page 4Linked to original sources
PubMed1986

Stage III carcinoma of cervix. The importance of increasing age and extent of parametrial infiltration.

The relative importance of a number of potential prognostic factors was analysed for a sequential group of 296 patients with stage III carcinoma of the cervix who had been treated in a mature prospective clinical trial. Using a log-rank analysis of survival curves generated by the life-table method increasing age (p = 0.05) and extent of parametrial infiltration (p = 0.001) were found to be significantly related to prognosis. These two factors were further demonstrated to be independent variables and, of the two, parametrial extension (p = 0.002) was more significant than increased age (p = 0.035). Involvement of the lower third of the vagina, the presence of bullous oedema and the histological differentiation of the disease were not prognostically significant in this study. It is suggested that tumour volume as defined by extent of parametrial infiltration is a sufficiently good prognostic factor to be incorporated into a revised staging system.

Adenocarcinoma↗
PubMed1986

Pulmonary carcinoid tumours: a clinico-pathological study of 35 cases.

A clinico-pathological study of 35 bronchial carcinoid tumours was undertaken. Age, T stage, N stage, lymph node involvement, number of lymph nodes involved and number of cigarettes smoked per day were the clinical variables affecting survival. The histological variables related to survival were; mitotic count, necrosis, nuclear pleomorphism, vascular and lymphatic permeation and an undifferentiated growth pattern. All these features could be detected with routine histological stains, whereas immunocytochemical methods for demonstrating neuron specific enolase were of no help in assessing the prognosis. However there was a tendency for a well differentiated neuroendocrine carcinoma to stain strongly in some areas with carcinoembryonic antigen.

Adenoma↗
PubMed1985

Radiotherapy alone for patients with operable carcinoma of the lung.

Between 1966 and 1980, 72 patients with operable carcinoma of the lung were treated primarily with radiotherapy because coexisting, nontumor related medical problem, or patient refusal prevented thoracotomy. We compared results obtained in this group with results obtained by thoracotomy in 123 consecutive patients over the age of 70, who were assessed in a similar fashion, but who underwent thoracotomy. All patients in both groups had proven, nonsmall cell carcinoma of the lung without clinical, laboratory, or radiologic evidence of tumor spread. All patients in both groups had a negative staging mediastinoscopy, and bronchoscopic findings consistent with operability. Many of the patients treated with radiotherapy had less than a curative dose as their general medical condition prevented a course of radical radiotherapy. It is apparent, however, that the results of radiotherapy for patients with operable carcinoma of the lung may be disappointing and that for patients who are marginal in terms of operative risk, the benefits of surgical resection may warrant the risks involved.

Actuarial Analysis↗
PubMed1983

Radiotherapy in seminoma of the testis.

Five hundred and forty-seven patients with histologically proven seminoma of the testis were treated by radiotherapy between 1960 and 1978 using a standard method. Of these, 448 patients had 'early' disease and a life-table survival of 94% at 5 years was achieved. Survival was significantly improved in patients treated in later time periods. Survival in more advanced disease was less good (62% in Stage IIB, 51% in Stage III and 13% in Stage IV at 5 years). The radiotherapeutic management of this tumour is discussed.

Dysgerminoma↗