Search PubMed⌕ Search

Biomedical subjects

V Bhushan

Publications and source records attributed to V Bhushan.

65 records · Page 4Linked to original sources
PubMedDate not supplied

Clinical and biochemical changes in chronically exposed organophosphate workers.

Health effects of occupational organophosphate exposure were investigated by subjecting 22 workers chronically exposed to an organophosphate pesticide, fenthion (O,O-dimethyl-O-(4-methylmercapto-3-methylphenyl)-phosphorothioate) to clinical evaluation, estimation of serum cholinesterase, serum alkaline phosphatase (SAP), serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). The mean age of the workers was 31 years and the mean duration of fenthion exposure 8.2 years. Headache (59%), giddiness (50%), ocular symptoms (27%) and paresthesia (18%) were the commonest symptoms. Serum acetylcholinesterase and butyrylcholinesterase levels were significantly lower than in controls. After withdrawing the workers from organophosphate exposure for 3 weeks, the follow-up study revealed absence of transient symptoms. There was no change in their neurological status, and serum acetylcholinesterase and butyrylcholinesterase levels were raised significantly, whereas the other serum enzymes showed no significant change. For monitoring of occupational organophosphate exposure, the importance of both clinical and biochemical parameters is emphasised.

Adult↗
PubMedDate not supplied

Serum protein profile in normal pregnancy and in relation to parity.

Forty pregnant females of third trimester and their twenty non-pregnant controls were screened for Hb%, PCV and serum protein differentials in relation to parity. Paper electrophoresis method revealed significant rise in mean levels of serum alpha 1, alpha 2 and beta-globulins in pregnant females as compared to non-pregnant controls, which may be due to the rise in pregnancy-associated-proteins. Radial immunodiffusion method revealed rise in mean serum IgM level with increasing parity, whereas a decrease in mean serum IgG level was observed which might be due to the placental membrane-transfer and/or decreased IgG synthesis. Haematological investigations revealed decreased Hb% and PCV which may have been caused both due to increased demand of nutrients as well as by haemodilution, associated with water retention during pregnancy.

Adult↗
PubMedDate not supplied

Accidental poisoning in children in Lusaka.

An analysis of 378 cases of accidental poisoning by ingestion or inhalation in children admitted to the University Teaching Hospital, Lusaka, in 1978, is presented. The distribution was as follows: paraffin poisoning (57.1%), food poisoning (18.3%), other household poisons (11%) and "medicines" (10.8%). In 9 cases poison could not be identified. Two patients (0.5%) died.

Adolescent↗
PubMedDate not supplied

Differential solubility test for haemoglobin S.

Two hundred and seventy-eight blood specimens were examined, both by the Sicklequik solubility test and haemoglobin electrophoresis on paper. Two hundred and sixty specimens (96.04%) were correctly identified by the Sicklequik solubility test. Forty-nine out of fifty (98%) specimens were interpreted identically when examined independently by two observers.

Blood Protein Electrophoresis↗
PubMedDate not supplied

Surgery in patients with congenital coagulation disorders.

BACKGROUND: Surgery is occasionally necessary in patients with congenital coagulation disorders. Major surgery for patients with haemophilia was not being done in India until recently. This paper reports the experience of a single referral centre. METHODS: The data of 52 patients who were operated upon were collected from the hospital records retrospectively between 1984 and 1986 and prospectively thereafter. They included the surgical procedure performed, replacement therapy used and complications encountered. RESULTS: Fifty-nine procedures were performed of which 26 were major, 30 minor and 3 were diagnostic angiograms. Blood components produced in the hospital blood bank were commonly used for replacement and primary haemostasis was achieved in all patients. Delayed bleeding due to inadequate factor levels occurred in 12 procedures and was controlled by increasing the factor replacement. One patient died of suspected acute myocardial ischaemia. CONCLUSION: In India surgical procedures can be safely performed in patients with congenital coagulation disorders.

Adolescent↗