A case of posterior cranial fossa meningioma without dural attachment is presented. The patient was 8 years old. The tumour was mostly in the cerebellum and was presumably arising from the telechoroidea. Meningiomas without dural attachment are uncommon. They are rarer in the posterior fossa and in very young children.

Child↗

PubMedDate not supplied

Development of murine pre-T cells into gamma delta T-cell receptor bearing cells.

Murine T cells bearing the gamma delta T-cell receptor (gamma delta TCR) are the major lymphocyte subset in the thymus early in fetal development, and postnatally they are the major population of T cells in the epithelia of nonlymphoid tissues including the intestine, skin, tongue, lung, and reproductive organs. The site of origin of gamma delta T-cell precursors (pre-T cells) changes during fetal development, reflecting the sites of active hematopoiesis. In addition, the pattern of expression of specific gamma delta TCR variable (V) region genes changes during fetal and neonatal development, and is unique in different epithelial tissues postnatally. We herein review the literature describing these developmental changes and provide a model for the developmental pathways of murine gamma delta T cells.

Animals↗

PubMedDate not supplied

Acid inhibiton in insulin test- a preliminary report.

The initial suppression of acid secretion in Insulin Test has been a subject of various interpretaitons. A study of hypothalamic recordings in a patient undergoing sedative neurosurgery for behaviour disorders revealed marked suppression of electrical activity in the lateral hypothalamic nucleus within three minutes after the injection of insulin, followed later by spike formation corresponding to parasympathetic stimulation, when hypoglycaemia is established. It appears that the initial suppression of acid secretion is due to a direct action of insulin, suppressing electrical activities of lateral nucleus, the spike formation occurring later, corresponding to onset of hypoglycaemia with stimulation of the nucleus and consequently gastric secretion.

Adult↗

PubMedDate not supplied

Isoproterenol infusion--an alternative to exercise testing.

Isoproterenol, as an exercise simulating agent, was evaluated in twenty subjects, ten normal volunteers and ten with Coronary Artery Disease (CAD). Both groups were evaluated using 0.5 ug increments of intravenous infusion of isoproterenol every 3 minutes with computerised ECG (Marquette Electronics--MAC PC) monitoring. The normal volunteers did not have significant ST segment depression even at heart rates of 130 BPM. The CAD groups showed diagnostic ischaemic ST segment depression at heart rates below 130 BPM. None of the subjects had any serious complications during or after the test. Isoproterenol infusion is a better alternative to exercise testing.

Adult↗

PubMedDate not supplied