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Biomedical subjects

V Balasubramaniam

Publications and source records attributed to V Balasubramaniam.

At least 19 recordsLinked to original sources
PubMed1994

The role of cytomegalovirus (CMV) infection in congenital diseases in Malaysia.

A previous cross-sectional serological survey of various age groups (0-55 years) of the Malaysian normal population showed that cytomegalovirus (CMV) infection is highly endemic in Malaysia. A total of 1,688 infants (0-4 months) with congenital abnormalities were screened for evidence of congenital CMV infection and the rest of the TORCHES (TOxoplasmosis, Rubella, Cytomegalovirus, HErpes simplex, Syphilis) group of congenital infections. Congenital CMV infection was detected in 193 (11.4%) infants which is significantly higher than the prevalence of congenital syphilis (4%), congenital rubella infection (3.7%), congenital toxoplasma (1.0%) and congenital herpes simplex virus infection (0%). Of the 193 cases, 10.4 per cent had CNS defects. We concluded that 1) congenital CMV appears to be the most important cause of congenital infections among the TORCHES diseases in Malaysia; and 2) secondary rather than primary infections or reactivation is responsible for most of the intrauterine CMV infection in Malaysia, as primary infection is usually associated with neurological involvement.

Cytomegalovirus Infections↗
PubMed1993

Comparison of HIV antibody profiles in intravenous drug users and individuals infected by the sexual route.

HIV-1 antibody patterns in two groups, those infected by the intravenous route (IV drug users) and those infected by the sexual route (prostitutes, male homosexuals and sexually transmitted disease patients) were compared using the Western blot technique. A total of 160 cases were studied. The intravenous drug user (IVDU) group appeared to respond to fewer antibody markers than the sexually infected group, the difference being significant for markers p31, p51, p55, p66, gp41 and gp120. Furthermore, a higher proportion (63%) of the sexually infected group carried antibodies to all Western blot markers as compared to the IVDU group (49%).

Acquired Immunodeficiency Syndrome↗
PubMed1978

Stereotactic cingulumotomy for drug addiction.

This paper analyzes the results of surgical treatment of 73 patients with drug addiction. They were treated by lesions in the anterior cingulum. Morphine, Pethidine (meperidine) and alcohol were the common drugs of addiction. Selection of cases, rationale for surgery and operative technique are discussed. Follow-up varied from 1 to 6 years. Results of surgery indicate this procedure as the most promising one for cure of drug addiction.

Adult↗
PubMed1976

Stereotactic surgery of the limbic system in epilepsy.

During the routine follow-up of results of stereotaxic surgery in the patients treated for behaviour disorders, it was found that some of them had a bonus relief from seizures, Out of 260 amygdalotomies, 54 hypothalamotomies and 5 thalamolaminotomies performed for behavioural problems, 107 patients suffered from associated seizure disorder. 76 of them (71%) showed considerable relief from seizures following surgery. This is detailed. It is hypothesized that probably these nuclei of the "limbic system" either initiate and/or propagate seizure activity. This view is supported by the "improvement" in EEG in addition to the clinical improvement seen in these patients.

Amygdala↗
PubMed1975

Why hemispherectomy?

A series of ten cases of infantile hemiplegia with behaviour disorders and with of without fits treated by unilateral stereotactic amygdalotomy is described. Out of the eight cases with fits good releif was seen in six and amelioration of the seizures in two. The behavioural disorders were well controlled in all the patients. When this procedure is compared with hemispherectomy, it is felt that operation of stereotactic amygdalotomy can be done as the procedure of first choice. Some hypotheses have been advanced to explain the modus operandi of the operation.

Adolescent↗