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Biomedical subjects

V B Tuason

Publications and source records attributed to V B Tuason.

8 recordsLinked to original sources
PubMed1992

Cognitive therapy and pharmacotherapy for depression. Singly and in combination.

Cognitive therapy and imipramine hydrochloride tricyclic pharmacotherapy, each singly and in combination, were compared in the treatment of nonpsychotic, nonbipolar depressed outpatients. One hundred seven patients were randomly assigned to 12 weeks of active treatment; 64 patients completed the full course of treatment. Rates of attrition were high but not differential. Cognitive therapy and pharmacotherapy did not differ in terms of symptomatic response, either in the primary analyses or in secondary analyses restricted to more severely depressed outpatients. Initial severity did predict response within pharmacotherapy alone, but not within cognitive therapy. Combining cognitive therapy with pharmacotherapy did not markedly improve response over that observed for either modality alone, although such nonsignificant differences as were evident did favor the combined treatment. Two patients died as a consequence of suicide attempts, both of which involved study medication.

Adolescent↗
PubMed1992

Differential relapse following cognitive therapy and pharmacotherapy for depression.

Patients successfully treated during a 3-month period with either imipramine hydrochloride pharmacotherapy, cognitive therapy, or combined cognitive-pharmacotherapy were monitored during a 2-year posttreatment follow-up period. Half of the patients treated with pharmacotherapy alone continued to receive study medications for the first year of the follow-up. All other patients discontinued treatment at the end of the acute treatment phase. Patients treated with cognitive therapy (either alone or in combination with medication) evidenced less than half the rate of relapse shown by patients in the medication--no continuation condition, and their rate did not differ from that of patients provided with continuation medication. It appears that providing cognitive therapy during acute treatment prevents relapse. Whether this preventive effect extends to recurrence remains to be determined.

Adolescent↗
PubMed1992

Pharmacy and Therapeutics committee. Cost-containment considerations.

The Pharmacy and Therapeutics committee is a frequently used mechanism for health care organizations to meet mandated standards. The control that the committee has over the formulary is often seen as a potential way of controlling the expenditures for drugs. As the Pharmacy and Therapeutics committee is the means for the clinical staff to have an effect as to what agents are available to practitioners, it is incumbent on the committee members to have a clear idea of what their role should be in cost containment. An important concept that impacts on cost is that optimal health benefit is not necessarily the result of maximum expenditure. The welfare of the patient is paramount to all in the health care field; however, it is the task of clinicians to determine what constitutes optimal health benefit and to act as agents of the patient. Clinicians must maintain patient care as their top priority. Although health care expenditures are an extremely important issue, quality of patient care cannot be subrogated to a secondary concern.

Cost Control↗
PubMed1979

Physician marriages.

A questionnaire study of physicians' ratings of various aspects of their marriage, was sent to 100 randomly selected physicians in Ramsey County (St. Paul, Minnesota). Eighty per cent of the sample responded. All 80 had been married at least once. There were fewer divorces reported compared with the general population. The group of 80 rated their marriages above average. Spouses who were considered extroverted correlated very significantly with a good marriage rating. The educational level of the spouse did not correlate with the marriage rating. Working long hours was not associated with poor marriage ratings or divorce. No significant relationship was revealed in examining the study variables for grouped medical specialties.

Adult↗
PubMed1977

Depressive subtypes, blood pressure changes and response to treatment.

Blood pressure changes during treatment with an intravenous tricyclic (chlorimipramine) were systematically assessed on twenty depressed patients diagnosed as primary or secondary affective disorders according to research diagnostic criteria. Patients with primary affective disorder showed a significantly greater decline in systolic blood pressure during this treatment than patients with secondary affective disorder. The decline in the blood pressure paralleled clinical improvement. Differential changes in blood pressure appear to be one more instance of constitutional differences for depressive subtypes, and may prove to be practical and reliable predictors of treatment response to tricyclic antidepressants.

Adult↗
PubMed1976

Intravenous chlorimipramine and depressive subtypes.

An open clinical trial with intravenous chlorimipramine was carried out on twenty depressed inpatients, diagnosed as primary or secondary affective disorders following a classificatory scheme for use in psychiatric research. Eleven of twelve patients with primary affective disorders had a significant decrease in symptoms of depression at the end of two weeks. In contrast, eight patients with secondary affective disorders did not show such significant improvement. Changes in physiological parameters (systolic blood pressure) were significantly greater in the primary affective disorders than in the secondary ones. It is inferred from the results of this trial, that intravenous administration of chlorimipramine is a safe and feasible procedure, which may compare to electroconvulsive therapy in the treatment of severe unipolar and bipolar depressions.

Adult↗