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Biomedical subjects

V Andreoli

Publications and source records attributed to V Andreoli.

33 records · Page 2Linked to original sources
PubMed1978

Facilitation of social interaction through deindividuation of the target.

It was hypothesized that actors want their perception of a target to be consistent with the type of interaction they expect. It was predicted that subjects expecting to aggress would deindividuate their target through the selective recall of deindividuating information. Conversely, subjects expecting a prosocial interaction should individuate the target. Further, angry subjects should deindividuate the individual who angered them. Male subjects were either angered or not angered by an experimental confederate and then given the opportunity to either shock, reward, or have no interaction with him. Subjects recalled information about the confederate either prior to or after the learning task. Subjects expecting to aggress deindividuated the target, whereas subjects expecting a prosocial interaction individuated him. Angry subjects deindividuated the target, nonangry subjects did not. Since the selective recall of information occurred prior to the interaction, the deindividuation (individuation) was aimed at facilitating future behavior rather than justifying it.

Aggression↗
PubMed1977

Double-blind cross-over clinical comparison of two 2'-chloro benzodiazepines: 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (chlordesmethyldiazepam) versus 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in neurotic anxiety.

A group of 20 female neurotic inpatients has been treated with 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one-(chlordesmethyldiazepan)- 7-chloro-5(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) according to a double-blind cross-over design. For each drug clinical evaluations were performed by means of Hamilton's rating scale for anxiety states and of Overall and Gorham's brief psychiatric rating scale, at the beginning, after the first week and at the end of the two-week period of treatment, in opposite sequence. A statistically greater efficacy of chlordesmethyldiazepam in comparison to lorazepam was observed. Results are discussed with regard to benzodiazepine structure-activity relationships.

Adult↗
PubMed1975

Plasma tryptophan transport in normal and depressed subjects.

Depressed patients have a delayed clearance of i.v. injected labelled 1-tryptophan. A high affinity binding for the amino acid and a derangement of transport or distribution to tissues in the depressed are suggested as possible mechanisms.

Depression↗
PubMedDate not supplied

Promazine. A major plasma metabolite of chlorpromazine in a population of chronic schizophrenics.

N-Demethylation and dehalogenation of chlorpromazine (CPZ) were compared in six psychotic inpatients and in rats orally treated for 4 weeks with a daily CPZ dose of 5.4 (mean value) and 20 mg X kg-1 body weight, respectively, by measuring drug and metabolite plasma levels by means of a gas-liquid chromatography-nitrogen/phosphorus detector method. In patients the major plasma metabolite was found to be promazine (PZ), as identified by capillary GC-MS analysis. In rats, on the contrary, PZ represented only a small proportion of the compounds detected in plasma. The mean [PZ]/[CPZ] ratio after 4 weeks of treatment was 1.64 in patients and 0.08 in rats. The relative frequency of the N-demethyl metabolites in plasma, however, was similar in the two species. The mean [N-monodemethylated CPZ]/[CPZ] and [N-didemethylated CPZ]/[CPZ] ratios after 4 weeks of treatment were 0.45 and 0.24 in patients and 0.56 and 0.25 in rats, respectively. These findings suggest that dechlorination of CPZ in psychotic patients represents an important metabolic pathway.

Adult↗