Biomedical subjects

V Abeler

Publications and source records attributed to V Abeler.

40 records · Page 3Linked to original sources

PubMed1979

Sarcoidosis of the cardiac conducting system.

In a consecutive series of 2.950 routine autopsies two of 13 cases with sarcoidosis had cardiac involvement, one of which showed extensive granulomatous lesions in the sinus node. It is suggested that sudden death in this 52-year-old woman was caused by cardiac sarcoid involvement, possibly by leading to sinus arrest with cardiac standstill. However, because of the lack of electrocardiographic evidence, sudden death from ventricular fibrillation can not be excluded. As sudden death is a well-known complication in sarcoidosis, all such patients should be regularly screened for cardiac involvement in order to prevent fatal arrhythmias.

Adult↗

PubMed1979

Factors influencing the treatment of patients with stage Ia carcinoma of the cervix.

A total of 122 patients with Stage Ia carcinoma of the cervix was followed for 5 to 25 years. Eight recurrences were found, four of which were located in the vagina, cervix or the bladder and four on the pelvic wall. Five of the recurrences were detected after 5 years of follow-up. Tumour cells were found in blood vessels or lymphatic channels in eight patients and five of them developed metastases. It is proposed that only tumours with a depth of stromal invasion of less than 5 mm should be treated conservatively. If blood vessels or lymphatic channels contain tumour, we would recommend a Wertheim's hysterectomy or treatment by intracavitary and external irradiation.

Adult↗

PubMedDate not supplied

Development of brush cytology for detection of metaplastic and dysplastic nasal mucosa lesions. A preliminary report.

Nickel workers and wood workers have an increased incidence of carcinoma and of lesions of the nasal mucosa regarded as precancerous, i.e. dysplasia. This preliminary study demonstrates how metaplastic and dysplastic changes of the nasal epithelium may be diagnosed independently from cytological smears and from histological sections of samples from the same middle nasal turbinate. The sampling technique described yielded excellent material for cytological diagnosis and was also suitable for detailed cell surface characterization by scanning electron microscopy (SEM). Exfoliative cytology was found to be a reliable means of detecting preneoplastic changes in the nasal mucosa of individuals in selected risk groups. The sampling procedure causes less discomfort to the subjects and requires fewer resources than biopsy procedures.

Biopsy↗

PubMedDate not supplied

Colony-forming ability of human ovarian carcinomas in the Courtenay soft agar assay.

One hundred and twenty-one ovarian carcinomas were cultivated in soft agar according to the Courtenay & Mills (C-M) soft agar method. 71% of the tumours formed colonies, and 54% formed more than 30 colonies. Tumour cells from malignant fluids grew more frequently than did solid tumours, whereas the plating efficiencies (PEs) were higher in the case of solid tumours. In general, the PEs were higher and more tumours formed colonies in the C-M method compared to the Hamburger-Salmon (H-S) method. The colony-forming ability did not show statistically significant correlation to histopathological type and grade, previous treatment and S-phase fraction, but was related to DNA ploidy. In poorly differentiated tumours a high colony-forming ability was associated with a poor prognosis, whereas the opposite was found in well and moderately differentiated tumours. Differential dose-response relationships were obtained after in vitro treatment with anticancer agents.

Agar↗