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Biomedical subjects

V A Struchkov

Publications and source records attributed to V A Struchkov.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Change in the elastoviscosity of supramolecular DNA of sturgeon spawn after conservation with 4.5-5% NaCl].

Elastoviscosity of supermolecular DNA of beluga, sevruga and sturgeon pawn 6 months after conservation with 4.5-5% NaCl was studied. It is shown that a positive relation exists between elastoviscosity of SM DNA and its gustatory qualities. Therefore the value of elastoviscosity of SM DNA may be used for testing the changes of sturgeon pawn properties during conservation.

DNA↗
PubMedDate not supplied

[Changes in the composition of DNA-bound nonhistone protein in the thymus and liver of gamma-irradiated rats].

A supramolecular DNA complex (SC DNA) and DNA of a phenol nuclear matrix (PNM DNA) were extracted, by the phenol method, from rat thymus and liver 15 min following 10 Gy gamma-irradiation. The method of electrophoresis in polyacrylamide gel was used to study a composition of nonhistone proteins firmly bound to these DNA fractions. Irradiation was shown to induce the occurrence of new proteins and redistribution of proteins between SC DNA and PNN DNA of rat organs.

Animals↗
PubMedDate not supplied

[The somatic transformation of hens using high-polymeric DNA].

The transformation studies were performed on genetically pure hen breeds: the donor was Russian white (white colour is a dominant character), the recipient was New Hampshire (pale-yellow-brown). The high-polymeric DNA (2.10(9) dalton) was isolated from erythrocytes and testicles of donor cocks and introduced to a fresh-laid egg of the recipient by replacing the protein. Two sets of experiments on 570 eggs were made. The single injection with 150 micrograms of donor DNA to the recipient egg induced a stable change of feathering colour (particoloured) in 46% of the hatched chicks, which remained for 6 months of observation. Thus, the high-polymeric DNA possesses the property of somatic transformation, that evidences for a high intact character of these preparations.

Animals↗
PubMedDate not supplied

[The action of cortifen and corticosterone on the thymocyte nucleoid of mice in vivo and in vitro].

The effect of therapeutic doses of a hormonal cytostatic cortifen and corticosterone on supramolecular DNA structures of mice thymocyte nucleoid was studied. Capillary elastoviscometry showed that in vivo damage to supramolecular DNA complex structure there was a difference already two hours after injection of these agents. After 24 hours the damaging effects on nucleoid were markedly higher. The role of the hormone and alkylating group of cortifen in the cytotoxic action of antitumor agents is discussed.

Animals↗
PubMedDate not supplied

[Radioprotective action of a GGS-10 gaseous hypoxic mixture on the DNA supramolecular complex of normal tissues and sarcoma 45 of rats].

Gas hypoxic mixture (GHM-10) inhaled by rats during gamma-irradiation (2 to 20 Gy) effectively protects the supramolecular complex of DNA (SC DNA) in bone marrow and spleen, but fails to protect this complex in sarcoma 45. GHM-10 itself has been shown to induce rapid and prolonged, but irreversible, decrease in SC DNA elastic viscosity in normal tissues.

Animals↗
PubMedDate not supplied

[Effect of choline on the DNA supramolecular complex in rats and their survival following gamma irradiation].

The injection of choline-chloride (200 mg/kg) to rats 15 min before 6 Gy irradiation was shown to increase their survival rate over a period of 30 days, to prolong their average life, and to promote the complete restoration of elastoviscosity of DNA supramolecular complexes in thymus, spleen, liver and brain. When administered immediately after irradiation the drug increased the survival rate of rats.

Animals↗