Biomedical subjects
Publications and source records attributed to V A Shirokov.
The enantiomeric and diastereoisomeric analysis of nonproteinogenic methyl and hydroxy amino acids, obtained by asymmetric synthesis with the aid of a chiral regenerable reagent, has been carried out by liquid chromatography.
The report deals with an analysis of a 3-year follow-up of 38 patients of stage III stomach cancer. Tumor tissue disaggregation was investigated in the said patients using methods developed by the authors. The tumor disaggregation rate in patients dead within the first two years after surgery was higher (275 +/- 6.6) than in those dead within three years (237 +/- 10.8) or longer (235 +/- 7.2). High rate of tumor tissue disaggregation proved to be an unfavorable prognostic factor.
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In studying 62 strains of brucellae of all the known species an inductive enzyme--1-serine-hydrolyase(desaminating) was revealed in the intact cells and cell-free extracts. The activity of this enzyme depended on the species of brucellae and showed a sharp elevation in destruction of the cells with supersonic waves. Intact brucellae failed to desaminate treonine. A constitution enzyme 1-treonine-hydrolase (desaminating) was found in the cell-free extracts of Br. neotomae and brucellae isolated from murine rodents of the Northern Caucasus. Some properties of both enzymes were studied.
The authors review the results obtained in the treatment of some occupational diseases using physical factors. In osteoarthritis patients exposed to fluorine compounds good results were achieved at employment of decimeter-wave therapy combined with mud applications or sulfurated hydrogen baths. Patients with scapulohumeral periarthritis benefited from combination of EHF therapy with alternating magnetic field. Initial lead intoxication was effectively treated with magnetotherapy. Subjects with vascular pathology occupationally exposed to high temperature responded to magnetolaser impact on reflexogenic regions of the heart.