Biomedical subjects
Publications and source records attributed to V A Shestakov.
The experience with antithrombotic conservative treatment of 102 cases of acute thrombosis in the inferior vena cava system and in the deep veins of the lower extremities is generalized here. The suggested method permits to do away with thrombotic condition of hemostasis at a minimal risk of the occurrence of hemorrhagic complications.
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The action of rimantadin on the lambda phages was studied. The maximal inhibitory effect on the compound was observed on the 1st-6th minutes after the infection. There was no such effect on the T-4 and lambda phage replication. According to the data of incorporation of the radioactive precursors into the phage DNA, RNA, and proteins, and the manifestation of the rimantadin action on phage replication it was supposed that the inhibitory effect of rimantadin was determined by its influence on the RNA-polymerases, preponderantly on the phage RNA-polymerase.
Separate and combined action of Dimethylsulfoxid (DMSO) and Rimantadin on the reproduction of phages T--3, T--4, T--7 and lambda was studied. The maximum activation of reproduction of phages T--3 and T--7 by DMSO was observed for 6 minutes of latent period. At the same time this compound did not render the action on reproduction phages T--4 and, because they utilize cell RNA-polimerase. It was shown that DMSO stimulated the synthesis of T--3 phage DNA by action on T--3 phage RNA-polymerase. Combined application of both DMSO and Rimantadin eleminated in some degree its reciprocal effect on T--3 phage macromoelecules synthesis and complet eliminated inhibitory action of Rimantidin on infective phage T--3 production.
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An examination of 51 patients with embolism of the major arteries of the extremities demonstrated that embolism accompanied by an ascending or descending thrombosis was characterized by a more significant increase of blood coagulation, fibrinase and antiplasmin level, and an enhancement of erythrocytes aggregation, than embolism without protracted thrombosis. A correlation was observed between the nature of the pathologic process (presence of protracted thrombosis, increased erythrocytes aggregation) and the degree of ischaemia in the diseased extremity. At the same time, no correlation was found between the pathologic process and the duration of the disease history.
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