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Biomedical subjects

V A Shalimov

Publications and source records attributed to V A Shalimov.

At least 19 recordsLinked to original sources

[The ways of transmission of liver cell cytoplasma components to differential erythroblasts in erythropoiesis].

Intercellular interactions consisting of cytoplasmatic bridges and net-like ductal structures were revealed while electron-microscopic investigation in erythropoietic foci of hepar of mammals and amphibians. Hepatic microenvironment cells may influence the erythroblasts via the vascular net of the blood-producing foci and via the cytoplasm of interspaced cells of microenvironment of another kind. The presence of such morphologic structures makes possible to suppose the possibility of transit of ribosomes, protein molecules, lipids and other components of the microenvironmental cells cytoplasm into differentiating erythroblasts. Significant acceleration of maturing process of the red blood cells in erythropoietic foci was promoted by entrance of the cytoplasm components of the microenvironmental cells into erythroblasts.

Animals↗

[The influence of Chernobyl nuclear power station disaster on the erythropoietic cells in the microenvironment of the liver].

Erythropoesis activation, realizing by microenvironmental cells, was noted in hepar of the tailless amphibians R. Lessonae and R. Ridibunda, living in the Chernobyl AES alienation zone. Destructive changes, and the ribosome-protein complexes, fibrillar structures synthesis intensification was revealed in hepatocytes. Ribosome-protein complexes and fibrillar-granular material of hepatocytes enter the blood stream, where they incorporate into the erythroblasts cytoplasm. Focal hyperplasia and macrophages hypertrophy were revealed. Macrophages, transporting the hepatocytes cytoplasm components into erythroblasts and supplementing them with their cytoplasm synthesis products, take an active part in supply of differentiating red blood cells with different materials.

Amphibians↗

[Modelling of a combined immunodeficiency state by splenectomy and alloimmunization with lymph node antigens].

Autoimmune pathology was modelled in splenectomized animals by allosensitization with lymphoid tissue in association with Freund's adjuvant. It was found that splenectomy in guinea pigs produces stable disorders of homeostasis and morphological picture of the heart, liver, inguinal lymph nodes as well as a imbalance of the autoregulation mechanisms. The authors obtained an experimental model of autoimmune pathology that may be used for investigation of the pathogenesis of these states as well as for developing methods of corrective therapy.

Animals↗